Abstract: Provided are compositions that provide reduced aggregation of AAV2 particles. Also provided are methods of making and using the compositions. The compositions provided by the present disclosure generally comprise an AAV2 and a buffer with an aggregation reduction agent, such as trehalose in a high concentration (i.e., greater than 5%).

Abstract: Integrated circuit structures having varied epitaxial source or drain structures and device types are described. In an example, an integrated circuit structure includes a first plurality of horizontally stacked nanowires laterally spaced apart from a second plurality of horizontally stacked nanowires, each of the second plurality of horizontally stacked nanowires having a lateral width less than a lateral width of each of the first plurality of horizontally stacked nanowires. First epitaxial source or drain structures are at ends of the first plurality of horizontally stacked nanowires, each of the first epitaxial source or drain structures having a maximum lateral width. Second epitaxial source or drain structure are at ends of the second plurality of horizontally stacked nanowires, each of the second epitaxial source or drain structures having a maximum lateral width greater than the maximum lateral width of each of the first epitaxial source or drain structures.

Abstract: Systems and methods for troubleshooting issues based on historical resolution data. In one implementation, the disclosed system includes at least one processor and at least one non-transitory memory containing software code configured to cause the processor to: receive source data from a plurality of data sources; extract a plurality of keywords from the source data; store the plurality of keywords in a database; receive a natural-language user issue input from a chatbot; determine whether the received user input matches the keywords in the database, wherein a comparison result is inputted into a trained model; input the user issue input into the trained model; in response to the determining, transmit the resolution from the trained model to the chatbot.

Abstract: The present invention relates to communications methods and apparatus for session load balancing among session processing entities. An exemplary method embodiment includes the steps of receiving from a first device at a Signaling Front End Load Balancer (SLB) a first session initiation request destined for a second device; making a first session load balancing decision at the SLB with respect to the received first session initiation request; transmitting the first session initiation request to a first Session Border Controller (SBC) worker based on the first load balancing decision, the first SBC worker being one of a plurality of SBC workers forming a cluster of SBC workers, making a session mismatch determination at the first SBC worker with respect to a first session corresponding to the first session initiation request; and when the session mismatch determination is that a session mismatch has occurred notifying the SLB of the session mismatch.

Abstract: A technique facilitates deployment of open hole gravel packing equipment and sand control equipment downhole in a single trip. According to an embodiment, the technique utilizes a pipe string, e.g. a workstring or a drill string, for use in an open hole gravel packing operation. The pipe string is equipped with a sand control system having at least one filtration medium, Additionally, the pipe string comprises a valve and a valve actuation device. The valve actuation device is capable of being remotely activated in a manner allowing setting of one or more packers downhole without blocking subsequent flow through the pipe string.

Abstract: A technique facilitates actuation of a downhole device, such as an isolation valve. According to an embodiment, the downhole device may be in the form of an isolation valve member, e.g. a ball valve element, actuated between positions by a mechanical section which may comprise a shifting linkage. Actuation of the mechanical section, and thus actuation of the isolation valve member, is achieved by a trip saver section controlled according to a pressure signature which may be applied from a suitable location, e.g. from the surface. The trip saver section comprises a housing having an internal actuation piston coupled with the mechanical section. The trip saver section further comprises a pilot piston and a plurality of chambers formed in a wall of the housing and arranged to enable shifting of the actuation piston in response to a predetermined series of pressure pulses or other suitable pressure signature.

Abstract: Partition damper seal configurations for segmented internal cooling hardware apparatus are disclosed. An example airfoil includes an outer wall having a first rib spaced apart from a second rib on a surface of the outer wall, and an inner wall surrounded by the outer wall, the inner wall having a third rib protruding from the inner wall towards the surface of the outer wall, an end of the third rib detachably coupled to a portion of the surface of the outer wall, the portion of the surface positioned between the first rib and the second rib, the third rib and at least one of the first rib or the second rib to at least partially seal a flow passage between the inner and outer walls.

Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID), compositions, and methods of treating a severe acute respiratory syndrome.

Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID), compositions comprising same, and methods of treating a severe acute respiratory syndrome.

Abstract: The invention pertains to methods of purifying fusion proteins, in particular TNFR:Fc fusion proteins. Methods disclosed herein can be used to produce highly pure TNFR:Fc fusion proteins (e.g., etanercept) having a biological activity by removing hard to separate product related impurities such as clipped and/or mis-fold/aggregated TNFR:Fc fusion proteins.

Abstract: Methods and apparatus for gas turbine frame flow path hardware cooling are disclosed. An example engine fan case includes an outer band and an inner band, the outer band and the inner band connected using a double-walled vane, the vane including openings to pass cooling air flow from the outer band to an airfoil of the fairing, and an end segment seal, the seal formed on an edge of the fairing using an auxetic material.

Abstract: Embodiments disclosed herein include a motherboard. In an embodiment, the motherboard comprises a first layer with a first trace with a shape. In an embodiment, an insulating layer is provided over the first layer. In an embodiment, a second layer with a second trace with the shape is over the insulating layer. In an embodiment, the second trace is provided directly over the first trace.

Abstract: This disclosure provides methods, apparatuses, and computer-readable mediums for visualizing coverage area deficiencies. In an aspect, a method comprises retrieving, from a data storage, network performance data from a plurality of user wireless mobile devices; filtering the network performance data to narrow the dataset to data samples with accurate locations and dates; counting the number of data samples indicating a coverage deficiency in an area; comparing the number of data samples indicating the coverage deficiency in the area with a predefined threshold; rendering a map including the area; and displaying on the map a visual indicator of the coverage deficiency based on the number of data samples indicating the coverage deficiency in the area exceeding the predefined threshold.

Abstract: Methods, apparatus, and system for generating efficient cross-layer key performance indicators for monitoring, managing and debugging communications networks. An exemplary method embodiment includes the steps of: generating a plurality of different cross-layer key performance indicators (CL-KPIs) from a set of event data records corresponding to a first period of time and a first base protocol, each CL-KPI in said plurality of different CL-KPIs being for a different failure cause scenario; identifying a CL-KPI in the plurality of different CL-KPIs corresponding to the first period of time and the first base protocol having a highest CL-KPI value and determining a most likely failure cause scenario for said first base protocol to be the failure cause scenario associated with the identified CL-KPI having the highest CL-KPI value.

Abstract: The present invention relates to communications methods, apparatus and systems for providing media micro-services in a scalable and efficient manner. In an exemplary method embodiment, a packet plane control service entity performs the following operations: (i) receives a request from a Signaling-Session Border Controller to implement one or more micro-services on a media packet stream, the request including information about the media packet stream including stream identification information; generates instructions for one or more entities under the control of the packet plane control service entity to implement the requested one or more micro-services on the media packet stream; and communicates the generated instructions to the one or more entities under the control of the packet plane control service entity for implementation on the media packet stream.

Abstract: Partition damper seal configurations for segmented internal cooling hardware apparatus are disclosed. An example airfoil includes an outer wall having a first rib spaced apart from a second rib on a surface of the outer wall, and an inner wall surrounded by the outer wall, the inner wall having a third rib protruding from the inner wall towards the surface of the outer wall, an end of the third rib detachably coupled to a portion of the surface of the outer wall, the portion of the surface positioned between the first rib and the second rib, the third rib and at least one of the first rib or the second rib to at least partially seal a flow passage between the inner and outer walls.

Abstract: Methods, apparatus, and system for generating efficient cross-layer key performance indicators for monitoring, managing and debugging communications networks. An exemplary method embodiment includes the steps of: generating a plurality of different cross-layer key performance indicators (CL-KPIs) from a set of event data records corresponding to a first period of time and a first base protocol, each CL-KPI in said plurality of different CL-KPIs being for a different failure cause scenario; identifying a CL-KPI in the plurality of different CL-KPIs corresponding to the first period of time and the first base protocol having a highest CL-KPI value and determining a most likely failure cause scenario for said first base protocol to be the failure cause scenario associated with the identified CL-KPI having the highest CL-KPI value.

Abstract: A turbofan engine is provided. The turbofan engine includes a fan; a turbomachine operably coupled to the fan for driving the fan, wherein the turbomachine, the fan, or both include an engine component; a heat source; and a heat transfer system configured to reduce ice buildup or ice formation in the engine component, the heat transfer system in communication with the heat source, the heat transfer system comprising: a first heat transfer component in communication with the heat source; and a second heat transfer component that extends from the first heat transfer component to or through the engine component, wherein the first heat transfer component comprises one of a heat pipe or a graphene rod, and wherein the second heat transfer component comprises the other of the heat pipe or the graphene rod.

Abstract: The invention pertains to methods of purifying fusion proteins, in particular TNFR:Fc fusion proteins. Methods disclosed herein can be used to produce highly pure TNFR:Fc fusion proteins (e.g., etanercept) having a biological activity by removing hard to separate product related impurities such as clipped and/or mis-fold/aggregated TNFR:Fc fusion proteins.

Abstract: A gas turbine engine includes a fan located at a forward portion of the gas turbine engine, a compressor section and a turbine section arranged in serial flow order. The compressor section and the turbine section together define a core airflow path. A rotary member is rotatable with at least a portion of the compressor section and with at least a portion of the turbine section. An outlet guide vane assembly includes multiple outlet guide vanes located in an exhaust airflow path downstream of the turbine section. The multiple outlet guide vanes being spaced-apart circumferentially from each other over an angular range of about 360 degrees, and each multiple outlet guide vane defining a radial extent. At least one of the multiple outlet guide vanes includes a cold fluid passageway and another of the multiple guide vanes includes a heated fluid passageway.