Abstract: A computing system includes a host device and a root of trust (RoT) device for performing batch encryption and decryption operations facilitated by a direct memory access (DMA) engine. The host device generates a command table for batch processing of a set of address tables that each describe a set of data blocks of a file to be encrypted or decrypted. The DMA engine facilitates a DMA transfer of the command table from the host memory to an RoT memory of the RoT device. The RoT device then performs batch processing of the address tables referenced in the command table. For each address table, the DMA engine copies a set of data blocks from the host memory to the RoT memory, a cryptographic engine encrypts or decrypts the data blocks, and the DMA engine copies the transformed data blocks back to the host memory.

Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods provide signal boost upon detection of target nucleic acids of interest in less than one minute and in some instances instantaneously at ambient temperatures down to 16° C. or less, without amplification of the target nucleic acids yet allowing for massive multiplexing, high accuracy and minimal non-specific signal generation.

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A first type of ferroelectric capacitor comprises electrodes and an insulating layer comprising ferroelectric oxides. In some embodiments, the electrodes and the insulating layer comprise perovskite ferroelectric oxides. A second type of ferroelectric capacitor comprises a ferroelectric insulating layer comprising certain monochalcogenides. Both types of ferroelectric capacitors can have a coercive voltage that is less than one volt. Such capacitors are attractive for use in low-voltage non-volatile embedded memories for next-generation semiconductor manufacturing technologies.

Abstract: Systems and methods for blockchain ledger growth management using separation of a blockchain ledger into multiple blockchain ledgers (each ledger having a state that can be tracked and used). The systems and methods also include linking the separated ledgers by utilizing a linking application and smart contracts added to the separated ledgers.

Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.

Abstract: A computerized-method for providing an indication as to an availability of a communication-channel type that is used during an interaction with a customer, via a web app is provided herein.

Abstract: A system and method for unified autodial campaign management, comprising a campaign management console, a data services engine, a traffic shaper, an agent desktop, Control agent desktop, an auto-dialer, and a simple dialer which allows enterprises to conduct unified communications campaigns without differentiating between prior expressed written consent consumers, and those who have not provided prior expressed written consent, to being autodialed or receiving artificial or pre-recorded voice messages, allowing for compliance with regulations regarding such consent without splitting or bifurcating or otherwise hampering communications campaigns for the enterprise customers.

Abstract: Systems, methods, and apparatuses relating to access synchronization in a shared memory are described. In one embodiment, a processor includes a decoder to decode an instruction into a decoded instruction, and an execution unit to execute the decoded instruction to: receive a first input operand of a memory address to be tracked and a second input operand of an allowed sequence of memory accesses to the memory address, and cause a block of a memory access that violates the allowed sequence of memory accesses to the memory address. In one embodiment, a circuit separate from the execution unit compares a memory address for a memory access request to one or more memory addresses in a tracking table, and blocks a memory access for the memory access request when a type of access violates a corresponding allowed sequence of memory accesses to the memory address for the memory access request.

Abstract: Permission to execute a remote procedure call as requested by a first vehicle-enabled application over a first connection is validated using permissions assigned to the first vehicle-enabled application according to a policy table of the vehicle. Permission to execute the remote procedure call as requested by the second vehicle-enabled application over the second connection as forwarded to vehicle over the first connection is validated using permissions assigned to the second vehicle-enabled application according to the policy table of the vehicle.

Abstract: A computing device receives one or more network communication anomaly conditions that indicate abnormal network communication traffic for a class of devices associated with the computing device; monitors network communication data of the computing device; determines whether the network communication data of the computing device satisfies the one or more network communication anomaly conditions; and responsive to determining that the network communication data of the computing device satisfies the one or more network communication anomaly conditions, performs an anomaly detection operation for the computing device.

Abstract: Devices often receive content items to be saved for later presentation to a user. In some instances, the content of the message is analyzed to retrieve supplemental information from external data sources, such as a map to a location discussed in a message. However, such supplementing often fails to reflect the personal context of the content item to the user, who may not easily recall the associated personal context when the content item is later presented. Instead, for a content item to be saved, a device may evaluate personal data sources to identify the personal context of the content item to the user, and add personal context annotations to a content item record of the saved content item. Later, during a presentation of the content item to the user, the personal context annotations may be included as a reflection of the personal context of the content item to the user.

Abstract: The invention relates to a personal cleansing composition that delivers enhanced deposition of sunscreens on to the topical surface of the body. The composition more particularly provides for such wash off compositions that ensure that the sunscreens incorporated therein are stable and due to the high deposition on to surface provide high Sun Protection Factor (SPF). This is achieved through combination of two select water-soluble sunscreens in a high surfactant containing composition.

Abstract: The present invention relates to a closed loop subsea cooling system with a subsea cooler. A coolant pump assembly is located in a dedicated, sealed, gas filled, coolant pump housing in coolant fluid connection with the at least one subsea cooler. A heat sink in a dedicated sealed, gas filled, electronics housing is in coolant fluid connection with the subsea cooler. An accumulator is in coolant fluid connection with the subsea cooler, whereby the electric coolant pump is adapted to pump coolant through the at least one subsea cooler, the at least one heat sink and back to the at least one electric coolant pump assembly, forming a closed loop subsea cooling circuit.

Abstract: Provided herein are methods and compositions for the separation of an adeno-associated virus (AAV) particle from a mixture of the AAV and at least one contaminant using anion exchange chromatography. These methods and compositions allow for improved purification of complete AAV particles from contaminants such as AAV particles that lack a complete genome (e.g., empty capsids) and AAV degradation products.

Abstract: Provided herein are methods and compositions for the separation of an adeno-associated virus (AAV) particle from a mixture of the AAV and at least one contaminant using anion exchange chromatography. These methods and compositions allow for improved purification of complete AAV particles from contaminants such as AAV particles that lack a complete genome (e.g., empty capsids) and AAV degradation products.

Abstract: A method includes obtaining a graph that includes a plurality of nodes each representing a computational job and connected to one or more other nodes via edges. Each edge represents a dependency between two connected nodes. For each computing device of a distributed computing system, the method includes obtaining resource characteristics. The method includes slicing, based on the dependencies of connected nodes, the graph into a plurality of sub-graphs each including one or more nodes. For each respective sub-graph, the method includes determining a computational cost of the respective sub-graph and distributing, based on the computational cost and the resource characteristics, the respective sub-graph to the respective one of the computing devices. The method includes receiving a respective result from the respective one of the computing devices based on execution of the computational jobs. The method includes determining a total result based on each respective result.

Abstract: The present invention provides an improved lipid nanoparticle formulation encapsulating mRNA comprising DEPE as a helper lipid.

Abstract: The present invention relates to compositions and methods for lysing cells and isolating and/or purifying adeno-associated virus particles or adenovirus particles using a detergent selected from the group of alkyldimethylamine oxides.

Abstract: Methods for treating or preventing prurigo nodularis (PN) in a subject are provided. Methods comprising administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof, are provided.