Abstract: The present disclosure relates to variant engineered nucleic acid-guided nucleases that may be used in CRISPR-based cascade assay systems to detect one or more target nucleic acids in a sample. The variant nucleases comprise an activity such that double-stranded DNA substrates do not bind to or are not cleaved by variant LbCas12a nuclease, or bind to or are cleaved very slowly by the variant nuclease, however single-stranded DNA substrates can bind and are cleaved by the variant nuclease, and wherein the variant nuclease exhibits both cis- and trans-cleavage activity.

Abstract: An article of manufacture includes a non-transitory machine-readable medium. The medium includes instructions that cause a processor to execute a shift instruction. The shift instruction is to cause a source data in memory to be shifted left or shifted right. The shift instruction is to include a source parameter and a bit size parameter. The processor is to execute the shift instruction through a shift of a first source word of the source data by the bit size parameter to yield a first intermediate word, a shift of a second source word of the source data by the bit size parameter to yield a second intermediate word and a first set of shifted-out bits, and through execution of a logical OR operation on the first intermediate word and the first set of shifted-out bits to yield a first result word.

Abstract: An example operation may include one or more of receiving, by a processing node, a plurality of documents reflecting at least one action performed on supply-chain assets at a location of an asset supply-chain node, translating, by the processing node, the plurality of the documents into a plurality of entry and exit events of the supply-chain assets, and generating incomplete or non-chronological supply chain assets-related data based on the plurality of the entry and the exit events.

Abstract: A method for managing network attached storage (NAS) assets includes obtaining, by a backup manager, a backup request for backing up the NAS assets, in response to the backup request: determining a number of streams available to be performed in parallel by a set of backup agents, obtaining a set of slices associated with the NAS assets, assigning a portion of the set of slices to the streams based on the number of streams, initiating a backup operation based on the portion of the set of slices, monitoring, after initiating the backup operation, the backup operation to identify a stream of the streams is available, and assigning, based on the identifying, a slice of the set of slices to the stream.

Abstract: Certain embodiments are directed to methods and compositions for treating cancer, specifically colorectal cancer by administering an aldose reductase inhibitor and an immune checkpoint inhibitor to a subject in need thereof. Certain embodiments are directed to methods of treating a subject having cancer comprising, administering (i) a composition comprising an aldose reductase specific inhibitor and (ii) a composition comprising an immune checkpoint inhibitor to the subject having melanoma, head and neck, or colorectal cancer.

Abstract: Methods, systems, and computer program products for automated domain-specific constrained decoding from speech inputs to structured resources are provided herein.

Abstract: A hardware monitor arranged to detect out-of-bounds violations in a hardware design for an electronic device. The hardware monitors include monitor and detection logic configured to monitor the current operating state of an instantiation of the hardware design and detect when the instantiation of the hardware design implements a fetch of an instruction from memory; and assertion evaluation logic configured to evaluate one or more assertions that assert a formal property that compares the memory address of the fetched instruction to an allowable memory address range associated with the current operating state of the instantiation of the hardware design to determine whether there has been an out-of-bounds violation. The hardware monitor may be used by a formal verification tool to exhaustively verify that the hardware design does not cause an instruction to be fetched from an out-of-bounds address.

Abstract: Various arrangements for performing intelligent cellular channel management are presented herein. A physical cellular communication channel may be established between a user equipment (UE) and a cellular network for sending a short message service (SMS) message in response to a cellular service request from the UE. One or more characteristics of the UE, the SMS message, or both may be analyzed. A duration of time for which the physical cellular communication channel is to be kept active may be based on the analyzed one or more characteristics. A channel maintenance instruction may be transmitted to keep the physical cellular communication channel active based on a cellular network messaging controller determining to adjust the duration of time for which the physical cellular communication channel is kept active.

Abstract: Disclosed herein are polymers formed by the condensation of bis(hydroxycarbyl)-aminophenolic compounds with aldehydes. The condensation polymers include one or more repeat units having bis(hydroxycarbyl)amino functionality. The polymers are useful as antifoulants, antipolymerants, rheology modifiers, dehazers, polymerization retardants, surfactants, or a combination of these in one or more industrial process streams.

Abstract: Disclosed are oxyalkylated surfactants used in compositions and methods for inhibiting corrosion.

Abstract: A tourniquet for occluding blood flow to a limb is improved by the addition of proximal and distal strain gauges. The proximal strain gauge may be monitored under conditions of total blood flow occlusion for time-varying signals indicative of volumetric limb changes arising from the subject's blood flow in the proximal section of the limb. Upon a change in limb occlusion pressure, the signals from the proximal strain gauge can be observed to change also, and the working pressure in the tourniquet can be adjusted safely in response. Automated control systems may further use inputs from a distal strain gauge and/or from a sensor that detects induced pressure changes within the tourniquet to improve the control of the tourniquet working pressure during operation to avoid unwanted blood flow past the tourniquet.

Abstract: Disclosed herein are ethylene-based polymers generally characterized by a melt index of less than 15 g/10 min, a density from 0.91 to 0.945 g/cm3, a CY-a parameter at 190° C. from 0.2 to 0.6, an average number of long chain branches per 1,000,000 total carbon atoms of the polymer in a molecular weight range of 500,000 to 2,000,000 g/mol of less than 5, and a maximum ratio of ??/3? at an extensional rate of 0.03 sec?1 in a range from 3 to 15. The ethylene polymers have substantially no long chain branching in the high molecular weight fraction of the polymer, but instead have significant long chain branching in the lower molecular weight fraction, such that polymer melt strength and bubble stability are maintained for the fabrication of blown films and other articles of manufacture.

Abstract: Embodiments herein use transfer learning paradigms to facilitate classification across entities without requiring the entities access to the other party's sensitive data. In one or more embodiments, one entity may train a model using its own data (which may include at least some non-shared data) and shares either the scores (or an intermediate representation of the scores). One or more other parties may use the scores as a feature in its own model. The scores may be considered to act as an embedding of the features but do not reveal the features. In other embodiments, parties may be used to train part of a model or participate in generating one or more nodes of a decision tree without revealing all its features. The trained models or decision trees may then be used for classifying unlabeled events or items.

Abstract: A system (SYS) and related method for facilitating collimator adjustment in X-ray imaging or a radiation therapy delivery. The system comprises an input interface (IN) for receiving input data including i) an input image and/or ii) user input data including a partial collimator setting for a collimator (COL) of an X-ray imaging apparatus (IA). A collimator setting estimator (CSE) of the system computes a complemented collimator setting for the collimator based the input data. Preferably, the system uses machine learning.

Abstract: A valve arrangement for a pressurized fluid source includes a regulating valve poppet configured to translate along a longitudinal axis of a valve housing, and a linear stepper motor configured to control a position of the regulating valve poppet. The linear stepper motor is controlled by a closed loop control system based upon temperature and pressure feedback signals to actively control the position and stroke rate of the regulating valve poppet.

Abstract: Embodiments herein describe techniques for expressing the layers of a neural network in a software model. In one embodiment, the software model includes a class that describes the various functional blocks (e.g., convolution units, max-pooling units, rectified linear units (ReLU), and scaling functions) used to execute the neural network layers. In turn, other classes in the software model can describe the operation of each of the functional blocks. In addition, the software model can include conditional logic for expressing how the data flows between the functional blocks since different layers in the neural network can process the data differently. A compiler can convert the high-level code in the software model (e.g., C++) into a hardware description language (e.g., register transfer level (RTL)) which is used to configure a hardware system to implement a neural network accelerator.

Abstract: We describe a Tracheal Tube insertion facilitator (“modified bougie”) with superior ventilating capability to enable medical/paramedical personnel to place tracheal/bronchial tubes reliably in trachea/bronchus of the patients under anaesthesia or patients in respiratory distress, and provide respiratory support. This device is particularly useful in situations where the conventional tracheal intubation technique using a laryngoscope is difficult or near impossible. This device has a outer cylindrical member, inner hollow stylet and a dynamic cuff which inflates during Positive Pressure Ventilation/Jet ventilation, and hence enabling oxygenation in patients with respiratory distress even before the tracheal tube is inserted into the patient's airway.

Abstract: Aspects of the technology described herein provide a collaborative browsing experience in which real-time browsing activity and saved browsing activity of session collaborators in a collaborative browsing session are shared with the collaborators. A collaborative session may be initiated, which may create a tab group associated with the session and linked to a collaborator. Other collaborators may be invited to join the session, and additional tab groups for each collaborator may be created. The tab groups of the collaborators may be included in a collective tab group, which may be updated in real-time with changes made by any of the collaborators. For example, client changes may be handled locally and communicated to a service to which each client is connected. The service may sequence and broadcast the ordered changes to the clients, which may each implement the changes according to the sequence to synchronize a shared state amongst clients.

Abstract: A computer system includes one or more processors coupled to one or more memory devices containing computer-executable instructions which, when executed by the one or more processors, are configured to cause the computer system to: receive information related to a redemption opportunity; receive information related to a user profile of a user; detect a geographic location of a mobile device running a mobile wallet of the user; and generate, on the mobile device of the user based on the mobile device of the user being within a predetermined distance of a merchant and the user profile of the user, an alert that is displayed by the mobile device, wherein the alert includes a message comprising an image overlaid on a map indicating the geographic location of the merchant relative to the detected geographic location of the mobile device.

Abstract: A method of preventing formation of rust on a metal surface is provided. The method may include applying a polyamine onto the metal surface and applying a compound of formula (I) or salt thereof onto the metal surface. The compositions and methods disclosed herein may be used to inhibit corrosion of a metal surface in contact with an aqueous system.