Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the ?7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: A pharmaceutical composition comprising a compound of Formula I wherein R1 is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted amino; benzimidaz-2-yl; optionally substituted phenyl; loweralkyl-(R5)(R6) wherein one of R5 and R6 is selected from H and and the other is selected from carboxy, carboxy-loweralkyl and lower alkoxycarbonyl; NHCH2CH2OX wherein X represents an in vivo hydrolyzable ester; and R2 and R3 are independently selected from H, NO2, halo, di(loweralkyl)amino, cyano, C(O)OH, phenyl-S—, loweralkyl, and Z(O)OR7 wherein Z is selected from C and S and R7 is selected from H, lower alkylamino and arylamino; or pharmaceutically acceptable salts or certain in vivo hydrolyzable esters or amides thereof, in an amount effective to inhibit neurotrophin-mediated activity, and a suitable carrier, is described.

Abstract: To allow a receiving entity to derive a longer channel estimate while limiting overhead, a transmitting entity transmits a pilot on different groups of subbands in different time intervals. N subbands in the system are arranged into M non-overlapping groups. Each group includes P=N/M subbands that are uniformly distributed across the N subbands. The transmitting entity transmits the pilot on a different subband group in each time interval, and selects all M subband groups in M time intervals based on a pilot staggering pattern. The receiving entity derives (1) an initial impulse response estimate with P channel taps based on the pilot received on one subband group and (2) two longer impulse response estimates with different lengths used for data detection and time tracking. Each longer impulse response estimate may be derived by filtering initial impulse response estimates for a sufficient number of subband groups using a time-domain filter.

Abstract: Systems and apparatus are described for modifying fluid flow in a hard disk drive system to reduce cross-track motion. The systems and methods provide advantages because they include at least one flow modification element. In some embodiments, the flow modification system comprises a set of approximately parallel combs occupying a portion of the space present in between the disks in the hard disk drive system. The combs change the flow pattern of the fluid and act as a momentum channeling mechanism relative to the actuator assembly and suspension assemblies resulting in a considerable reduction in track misregistration error. Various embodiments of the invention include baffle-integrated combs, fixture-integrated combs, contoured enclosure surfaces, and enclosure attached combs.

Abstract: The present invention provides a system, a method and a computer program product for provisioning Virtual PIN pads on mobile devices, and for enabling customers to make payments using the provisioned Virtual PIN pads for the purchased goods and services. The system comprises a Virtual PIN pad and a transaction backend module. The Virtual PIN pad is a software emulation of a PIN Entry Device (PED) and is provisioned on the mobile device securely with all requisite keys and certificates, while conforming to all security standards of the payment domain. The transaction backend connects the Virtual PIN pad to a payment institution. The customer can make a payment by entering an account identifier card's PIN into the Virtual PIN pad. The Virtual PIN pad encrypts the entered PIN using certified security mechanisms, and transmits it over a secure channel to the payment institution for verification and payment authorization, via the transaction backend.

Abstract: A method for low-cost arsenic removal from drinking water using chemically prepared bottom ash pre-treated with ferrous sulfate and then sodium hydroxide. Deposits on the surface of particles of bottom ash form of activated iron adsorbent with a high affinity for arsenic. In laboratory tests, a miniscule 5 grams of pre-treated bottom ash was sufficient to remove the arsenic from 2 liters of 2400 ppb (parts per billion) arsenic-laden water to a level below 50 ppb (the present United States Environmental Protection Agency limit). By increasing the amount of pre-treated bottom ash, even lower levels of post-treatment arsenic are expected. It is further expected that this invention supplies a very low-cost solution to arsenic poisoning for large population segments.

Abstract: A method for monitoring performance of a gas turbine system comprises providing a plurality of combustor cans; placing a plurality of temperature sensors circumferentially around an exhaust plane of the plurality of combustor cans; operating the plurality of combustor cans while varying a plurality of gas turbine operating parameters, where exhaust gas issues from each combustor can of the plurality of combustor cans during operation; measuring temperature of the exhaust gas in the exhaust plane using the plurality of temperature sensors to obtain a plurality of individual temperature measurements; determining a correlation of the individual temperature measurements of exhaust gas temperature with corresponding individual combustor cans of the plurality of combustor cans issuing the exhaust gas; and developing a swirl model, where the model uses the correlation to predict swirl values in the exhaust plane as a function of the operating parameters.

Abstract: A technique for forming at least part of an array of a dual bit memory core is disclosed. Spacers are utilized in the formation process to reduce the size of buried bitlines in the memory, which is suitable for use in storing data for computers and the like. The smaller (e.g., narrower) bitlines facilitate increased packing densities while maintaining an effective channel length between the bitlines. The separation between the bitlines allows dual bits that are stored above the channel within a charge trapping layer to remain sufficiently separated so as to not interfere with one another. In this manner, one bit can be operated on (e.g., for read, write or erase operations) without substantially or adversely affecting the other bit. Additionally, bit separation is preserved and leakage currents, cross talk, as well as other adverse effects that can result from narrow channels are mitigated, and the memory device is allowed to operate as desired.

Abstract: At a base station receiver in a CDMA wireless communications system, in order to reduce reliance on the parameter values transmitted on a packet data control channel (PDCCH) to properly detect the high speed packet data transmitted on a packet data channel (PDCH) with which the PDCCH is code-division-multiplexed, data detection is performed using different possible values for at least one of the parameters and determining if a data packet derived from the PDCH detected under the different values produces a detected data packet that passes a CRC check. If a data packet derived from the received PDCH using a possible parameter value passes the CRC check, then the data packet is delivered to the output and an ACK is transmitted back to the transmitting mobile terminal.

Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

Abstract: In a wireless communication network, the location of an addressable receiver relative to the locations of a plurality of addressable sources of electromagnetic radiation is found using probabilistic models of the signal strength measured at the addressable receiver. The inventive method provides location determination on a finer spatial scale than was heretofore available. A region of interest is calibrated via a discrete-space radio map storing probability distributions of received signal strength at the measurement locations. The stored probability distributions are compensated for temporal variability and biases, such as through temporal correlations of the sampled received signal strength.

Abstract: The code space associated with the communication system is divided into at least two subspaces where each subspace is assigned to a different mode of operation. In one mode, such as a voice mode, each user is given full time access to a portion of the subspace associated with that mode of operation. In a second mode, such as a data mode, each user uses the entire subspace associated with that mode on a time shared basis. Additionally, in-sector handoffs from one Walsh code to another are used to more efficiently distribute the code space.

Abstract: A method of preparing an antioxidant polymer includes forming or obtaining a first polymer having reactive pendant groups, where the first polymer does not include cyclic anhydride repeat units, and derivatizing the first polymer with an antioxidant. Another method of preparing an antioxidant polymer includes forming or obtaining a first polymer having reactive pendant groups and derivatizing the first polymer with an antioxidant, where the antioxidant is attached to the first polymer by an acetal, amide, amine, carbamate, carbonate, ester, ether or thioether linkage or by a carbon-carbon bond. The invention is also directed to polymers that are generally prepared by these methods, compositions that include such polymers and methods of using such polymers.

Abstract: Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: wherein: R represents a group of Formula II or Formula III; one of A, B D or E is a N atom, the remainder being CH groups; R1 is selected from the group consisting of SO2Ar, C(O)Ar, CH2Ar and Ar; R2, R3 and R4 are independently selected from the group consisting of H and alkyl; ?represents a single or double bond, with the proviso that there is only one double bond in the ring at a time; n is an integer of from 1-3; Z is selected from the group consisting of C, CH and N, provided that when ?is a double bond, Z is C and when ?is a single bond, Z is selected from CH and N; Ar is an optionally substituted aryl group; with the proviso that when R is a group of Formula II, R1 is SO2Ar. Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.

Abstract: A method and apparatus are useful for decomposing a complex distribution of data by modeling the complex distribution as a sum of discrete simple distributions, and processing the simple distributions independently. The independent processing enables the complex distribution to be reconstructed without the simple distributions that are concluded to be spurious. The simple distributions preferably include one or more statistical distributions that are subject to being characterized by a reduced data set for efficient communication and reconstruction of the complex distribution. The modeling and processing steps preferably employ one or more evolutionary algorithms.

Abstract: The present invention is an apparatus and methods for selectably assessing a fallopian tube. The apparatus is a device that allows for treatment and/or the assessment of the patency of each fallopian tube independently by isolating at least one cornual regions from the uterine cavity. The method of the present invention is based on use of the device and allows for assessment of fallopian tube patency without the use of dyes of x-rays.

Abstract: The invention described herein is a framed fluid delivery device that is made up of a fluid-delivery cartridge for the timed-release delivery of a fluid contained therein, and a frame assembly for retaining the fluid delivery cartridge. The frame assembly is made up of a base portion that facilitates the delivery of fluid released from the fluid-delivery cartridge, at least one side panel associated with the base, and that secures the fluid-delivery cartridge within the frame assembly proximate the released fluid delivering means. Additionally, a fluid delivery device is disclosed that includes a fluid-delivery cartridge for the timed-release delivery of a fluid contained therein, the cartridge having a bottom, a top, and sides, and a dispersion pad positioned proximate the bottom of the fluid-delivery cartridge, wherein the dispersion pad at least partially surrounds the sides of the fluid-delivery cartridge.

Abstract: Methods are provided for depositing an oxygen-doped dielectric layer. The oxygen-doped dielectric layer may be used for a barrier layer or a hardmask. In one aspect, a method is provided for processing a substrate including positioning the substrate in a processing chamber, introducing a processing gas comprising an oxygen-containing organosilicon compound, carbon dioxide, or combinations thereof, and an oxygen-free organosilicon compound to the processing chamber, and reacting the processing gas to deposit an oxygen-doped dielectric material on the substrate, wherein the dielectric material has an oxygen content of about 15 atomic percent or less. The oxygen-doped dielectric material may be used as a barrier layer in damascene or dual damascene applications.

Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the ?7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: A slider is formed of an air bearing surface coated with a wear limiting coating that substantially limits surface wear of the air bearing surface encountered in proximity recording. The wear limiting coating is comprised of a wear inhibiting layer formed on the air bearing surface and a sacrificial layer formed on the wear inhibiting layer. The two coatings of the wear limiting coating have different mechanical properties so that the sacrificial layer is burnished, exposing the wear inhibiting layer. This design substantially limits the surface wear of the air bearing surface typically encountered in proximity recording, resulting in less debris accumulation, which could otherwise adversely affect the performance of the proximity recording head. This self-limiting burnishing action overcomes the flying height variation due to manufacturing tolerances and provides extremely small and uniform magnetic spacing, which greatly enhances the proximity recording.