Abstract: Various embodiments of systems and methods for distributed mobile enterprise application platform (MEAP) are described herein. In one aspect, the method includes receiving a request to be executed from a mobile device. Based upon the request, one or more middleware components capable of executing the request are determined from one or more remotely located servers. A middleware component from the one or more middleware components is selected for executing the request. The request is sent to the selected middleware component for execution. Based upon the execution, an output is received from the selected middleware component. In one embodiment, the output is stored in a backend system or sent to a portable device from which the request is received. In another embodiment, the output is sent to another middleware component for further execution.

Abstract: The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A? B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Abstract: The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

Abstract: A method for recovering from an error in a multi-core storage-system component is disclosed. In one embodiment, such a method includes detecting an error in a first core of a multi-core component. The method determines whether the error was one of (1) detected by the first core; and (2) detected by a core other than the first core. In the event the error was detected by the first core and the error is recoverable, the first core recovers from the error without substantially impacting operation of other cores in the multi-core component. In the event the error was detected by a core other than the first core and the error is recoverable, a core other than the first core recovers from the error without substantially impacting operation of other cores in the multi-core component. A corresponding apparatus and computer program product are also disclosed.

Abstract: In a waste treatment system and process, relatively low and high solids concentration streams are treated in generally parallel anaerobic reactors. The reactors may share a common wall or gas collecting cover. The reactors may also share a common downstream aerobic treatment unit. Solids produced during downstream treatment of effluent from one or both anaerobic reactors may be returned to the high solids concentration stream. The low solids concentration stream may be treated in an attached growth anaerobic digester.

Abstract: Provided are a method, system, and computer program product for managing monitored conditions in adaptors. An adaptor detects a condition comprising one of a plurality of monitored conditions and determines whether the detected condition is indicated on a recent condition list indicating conditions detected at the adaptors. The adaptor communicates the detected condition to cause the detected condition to be included in the recent condition list available at the adaptors in response to determining that the detected condition is not indicated in the recent condition list. Further, a system receives from one of the adaptors indication of a detected condition comprising one of a plurality of monitored conditions that is not indicated on a recent condition list. The received indicated condition is added to the recent condition list to produce an updated recent condition list. Transmission is caused of the updated recent condition list to the adaptors.

Abstract: The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

Abstract: A shortcut is created that groups and sequences actions to perform a task. A user may record actions both within an application and outside of an application to perform the task. For example, a user may record launching an application, accessing an item within the application, and performing one or more actions that involve the item. An Application Programming Interface (API) may be used by one or more applications to specify recordable actions that are associated with the application. For example, an application may specify that configuration settings for the application are not recordable while other user actions are recordable. After recording the actions for the task, a shortcut is created. The shortcut may be accessible from a home display of a mobile device (e.g. a start screen of a smart phone) and/or some other accessible location.

Abstract: A system, method, and computer program for component scattering, comprising calculating a bounding box for each of a plurality of parts; calculating a centroid corresponding to each of said bounding boxes; placing a first part having a bounding box and a centroid at said start position, and; placing said plurality of parts in a pre-determined direction from said first part; whereby in a single operation said plurality of parts are logically added to an assembly view in a pre-determined manner, and appropriate means and computer-readable instructions.

Abstract: An apparatus includes a destination edge device configured to receive a first validation packet according to a switch fabric validation protocol. The destination edge device is configured to validate multiple data paths through a distributed switch fabric from a source edge device to the destination edge device based on the first validation packet. The destination edge device is configured to send, in response to receiving the first validation packet, a second validation packet to a peripheral processing device. The destination edge device is also configured to send the second validation packet according to a validation protocol different from the first validation protocol.

Abstract: An apparatus includes a replication engine of a switch module of a multi-stage switch. The replication engine is configured to receive a first validation packet from an input port of the switch module. The replication engine is configured to determine multiple output ports of the switch module to which a data packet can be sent to reach a destination device associated with the first validation packet. The replication engine is configured to define multiple second validation packets based on a number of output ports from the multiple output ports such that each second validation packet from the multiple second validation packets is uniquely associated with an output port from the multiple output ports. The replication engine is configured to send the multiple second validation packets to an output module configured to forward each second validation packet from the multiple second validation packets to its associated output port.

Abstract: Systems and methods for detecting supported small form-factor pluggable (SFP) devices in an adapter are provided. One system includes multiple ports, each port configured to be coupled to a SFP device, a tracking device configured to store data representing a list of supported SFP devices for the adapter, and a processor coupled to each of the plurality of ports and the tracking device. The processor is configured to scan each port at start-up, determine if any of the ports is coupled to a non-supported SFP device, and disable any ports that are coupled to a non-supported SFP device. One method includes scanning each port at start-up, determining if any of the ports is coupled to a non-supported SFP device, and disabling any ports that are coupled to a non-supported SFP device. Also provided are computer storage mediums including computer code for performing the above method.

Abstract: Methods for screening for agents that modulate the activation state, i.e., active growth or persistence, of Mycobacterium tuberculosis (Mtb), methods of treating an Mtb infection in a subject using agents identified by the screening methods, and methods for screening for a latent Mtb infection in a subject are disclosed. The screening methods involve contacting a Mtb sensor kinase with an agent to be tested, then detecting the response of the Mtb sensor kinase to modulating ligands or detecting changes in the oxidation state of the heme iron of the Mtb sensor kinase. The methods for treating an Mtb infection in a subject involve administering a therapeutically effective amount of an agent identified by the screening methods. The methods for screening for a latent Mtb infection in a subject involve detecting carbon monoxide or nitric oxide binding to heme iron of Mtb sensor kinases.

Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

Abstract: In order to synthesize semi-interpenetrating polymer networks (semi-IPNs) with molecular sieve characteristics, polyetherimide/bismaleimide (PEI/BMI) chromophore composites were made through sol-gel technique. A tunable and compatible chemical structure with fine morphology was obtained through in situ controlled sol-gel polymerization, crosslinking, chemical modification and membrane fabrication. The novel semi-IPN, synthesized and assembled by using ethanol as polar protic modifier and pore former, had a superior structure and morphology suitable for making gas separation membranes. These semi-IPN membranes gave fifteen times higher gas flux without significant decrease in their gas permselectivity than membranes prepared from pure PEL The chemical structures of these novel semi-IPNs were characterized by using FTIR, XPS and SEM.

Abstract: Disclosed are a method, apparatus, and computer program product to reduce the detrimental effects of taking resources offline. A resource is taken offline in a storage network by quiescing activity to the resource providing notification that the resource will become unavailable, and taking the resource offline.

Abstract: The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory, and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

Abstract: A system, method, and computer program for component scattering, comprising calculating a bounding box for each of a plurality of parts; calculating a centroid corresponding to each of said bounding boxes; placing a first part having a bounding box and a centroid at said start position, and; placing said plurality of parts in a pre-determined direction from said first part; whereby in a single operation said plurality of parts are logically added to an assembly view in a pre-determined manner, and appropriate means and computer-readable instructions.

Abstract: Provided are novel pyrido-pyrimidine derivatives, having the structure of Formula (I): which can be used as anti-inflammatory agents. Also provided are pharmaceutical compositions comprising one or more pyrido-pyrimidine derivatives, as well as methods of treating autoimmune diseases, inflammation or associated pathologies, including for example, sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, comprising administering such compounds or pharmaceutical compositions comprising them.

Abstract: A system is provided to protect against ill-behaved microcode by balancing between an actual occurrence of a hardware problem and a microcode bug setting a flag appearing as a hardware problem. In this method, the error recovery is performed only on a single piece of hardware and no further error recovery action is taken on other pieces of similar hardware. The approach addresses the problem by treating a hit on one card as a hardware problem, but as a bug on subsequent cards. The invention keeps track of whether or not the same event has occurred on the same type of hardware so not to take action on more than one instance of the hardware. Subsequent hits on another instance of the hardware will not trigger the hardware related recovery on additional hardware.