Abstract: A method, apparatus and computer program product, the method comprising: obtaining a plurality of electrical signals obtained from a plurality of electrodes distally disposed on a catheter inserted into one or more chambers of a heart of a patient, wherein one or more electrical signals obtained from one or more electrodes of the plurality of electrodes obtains electrical activity in one or more locations within the heart; identifying one or more signals from the plurality of electrical signals as being emitted from one or more disconnected electrode, said identifying utilizing a correlation with a reference signal measured within the heart, wherein the reference signal is associated with a reference electrode; and generating a map of electrical activity within the heart based upon the plurality of electrical signals, excluding one or more electrical signals originating from the disconnected electrodes.

Abstract: A computer readable medium comprising instructions to be executed by one or more processors, the instructions configured to cause a system to estimate, based at least in part on signals received from a first position sensor of an expandable assembly disposed along a longitudinal axis, a position and longitudinal direction of the first position sensor; and estimate, based at least in part on signals received from a second position sensor of the expandable assembly, a position of the second position sensor. The instructions are further configured to cause the system to project the estimated position of the second position sensor on an axis defined by the longitudinal direction of the first position sensor and correct the estimated position of the second position sensor by projecting the estimated position of the first position sensor.

Abstract: Medical apparatus includes one or more magnetic field generators, which are configured to generate magnetic fields within a body of a patient. An invasive probe includes an insertion tube having a distal end, which is configured for insertion into the body, and a plurality of flexible splines configured to be deployed from the distal end of the insertion tube. Each spline includes a flexible, multilayer circuit board and a conductive trace that is formed in at least one layer of the circuit board and is configured to define one or more coils, which are disposed along a length of the spline and output electrical signals in response to the magnetic fields. A processor is coupled to receive and process the electrical signals output by the coils in order to derive respective positions of the flexible splines in the body.

Abstract: An irreversible electroporation and radio frequency ablation (IRE/RFA) generator includes an IRE pulse generator, harmonic filtration circuitry, and a waveform interleaver. The IRE pulse generator is configured to generate biphasic IRE pulses. The harmonic filtration circuitry is configured to convert the IRE pulses into an RF signal. The waveform interleaver, which is configured to receive the IRE pulses and the RF signal and generate an output signal having a composition of the adapted IRE pulses having a final shape and repetition rate, the converted RF sinusoidal signal, or a combined IRE/RFA output signal, by switching between the received IRE square pulses and the received converted RF sinusoidal signal.

Abstract: A catheter includes a shaft, an expandable frame, a first set of electrodes, and a second set of electrodes. The shaft is configured for insertion into an organ of a patient. The expandable frame is fitted at a distal end of the shaft. The first set of electrodes is disposed over a distal portion of the expandable frame, and configured to be placed in contact with a tissue in the organ. The second set of electrodes is disposed on a proximal portion of the expandable frame, and configured to be inter-connected to form a common electrode.

Abstract: A position sensor includes a flexible substrate formed into a three-dimensional (3D) shape. At least first and second field-sensing coils are formed in first and second respective layers of the flexible substrate, such that in the 3D shape the first and second field-sensing coils have first and second respective axes that are not parallel to one another.

Abstract: A medical apparatus includes a shaft, an expandable frame, a membrane, a diagnostic electrode, a reference electrode, and a processor. The shaft is configured for insertion into an organ of a patient. The expandable frame is coupled to a distal end of the shaft. The diagnostic electrode, which is disposed on an external surface of the expandable frame, is configured to sense diagnostic signals when in contact with tissue. The reference electrode is disposed on a surface of the expandable frame directly opposite the diagnostic electrode, wherein the reference electrode is electrically insulated from the tissue and is configured to sense interfering signals.

Abstract: A phacoemulsification valve for controlling flow of eye fluid, consisting of an enclosure, a first lumen within the enclosure, having a first and a second termination, a second lumen within the enclosure, intersecting the first lumen, so that the first lumen separates the second lumen into a first and a second section, and a pin, that slides within the first lumen between a first position, wherein the pin prevents transfer of the eye fluid between the first and second sections and a second position, wherein the pin permits transfer of the eye fluid between the first and second sections. The valve also includes a first coil, proximate to the first termination, which when energized transfers the pin between the first and second positions, and a second coil, positioned in proximity to the second termination, which when energized transfers the pin between the second and first positions.

Abstract: Apparatus, consisting of a power supply having a first electrical connection to a relatively high voltage source and connectable to ablation circuitry in a catheter via a second electrical connection. There are rechargeable first and second subsidiary power sources in the power supply. The apparatus also has a control unit, and a first switch alternately connecting the ablation circuitry to the first and second subsidiary power sources responsively to control signals from the control unit. The apparatus also has a second switch alternately connecting one of the first and second subsidiary power sources to the high voltage source for recharging thereof responsively to the control signals while the one of the first and second subsidiary power sources is disconnected from the ablation circuitry and another of the first and second subsidiary power sources is connected to the ablation circuitry by the first switch.

Abstract: A method of delivering a combined irreversible electroporation and radio frequency (IRE/RFA) signal during ablation that includes receiving a selection of a ratio of IRE/RFA energy and a selection of an interleaved sequence of a combined IRE/RFA waveform. The interleaved sequence includes one or more adapted IRE square pulses formed by adapting generated biphasic IRE square pulses to IRE pulses having a final shape and repetition rate using a biphasic pulse shaper, and one of more RFA cycles formed from converting the generated biphasic IRE square pulses into a RF sinusoidal signal using a harmonic filter. The interleaved sequence is generated by interleaving, into a single waveform, the one or more adapted IRE square pulses with one or more cycles of the converted RF sinusoidal signal. The combined IRE/RFA output signal is outputted to a catheter electrode inside a patient's heart for application to a target tissue location.

Abstract: An anti-vacuum surge (AVS) cartridge includes a solenoid valve with a magnetic plunger having parallel flattened surfaces, in a valve cavity of a rectangular or other similar cross section. The flattened surfaces of the plunger are oppositely disposed from each other and are in line with the flow path through the aspiration channel of the AVS cartridge.

Abstract: A method, including performing an ablation of tissue using a first high RF power for a short duration, suspending RF power for a predetermined period, and using a second high RF power for a short duration forming lesions with greater surface area and greater depth through resistive heating and thermal latency. High RF power may range between 75-95 W and short duration may range between 4-5 seconds.

Abstract: A safety circuit, in the form of a switch box, for coupling with a catheter, detects DC leakage or emission from an amplifier circuit of the catheter, and switches a switch to immediately terminates (cuts-off) power to the amplifier circuit. This immediate power termination instantaneously stops DC leakage, which if left unchecked or otherwise undetected, may reach the heart, and disrupt its electrical activity and cause other damage.

Abstract: An apparatus includes a base, including two motors and a mechanical coupling mechanism, and a cartridge shaped to define two stators and respective pairs of ports in fluidic communication with the stators. The cartridge is removably insertable into the base and includes two rotors disposed, respectively, within the stators. The mechanical coupling mechanism is configured to mechanically couple the rotors to the motors, respectively, such that, following insertion of the cartridge into the base, the motors rotate the rotors, thereby pumping fluid through the pairs of ports. Other embodiments are also described.

Abstract: A phacoemulsification simulation apparatus includes a trigger device, at least two sensors, and a processor. The trigger device configured to apply, to fluid at an inlet of a needle of a phacoemulsifier, a pressure profile as a function of time in response to an input waveform. The at least two sensors are configured to measure a pressure of the fluid at respective points in the phacoemulsification simulation apparatus. The processor is configured to (a) drive the trigger device with the input waveform, thereby causing the trigger device to apply the pressure profile to the inlet while the fluid is aspirated via an aspiration line, (b) receive measurements of the pressure of the fluid from the at least two sensors, and (c) analyze an aspiration performance of the phacoemulsifier in response to the measurements.

Abstract: A system for identifying vortices in a vector map including multiple vectors, the system includes a processor and an output device. The processor is configured to: (i) define one or more closed loops on the vector map, and (ii) for each closed loop, identify a plurality of the vectors that cross the closed loop, calculate a vector sum of the identified vectors, and decide based on the vector sum whether a vortex is located inside the closed loop. The output device is configured to indicate one or more identified vortices to a user.

Abstract: Apparatus, including a tube having proximal and distal ends and an internal lumen. The distal end may bend up to 270°, and the tube may be inserted into an eye. A planar resilient strip, having proximal and distal ends, is inserted into the internal lumen, and the strip distal end is fixed to the tube distal end. A coil spring is fixed to the strip proximal end so that a coil spring symmetry axis is coplanar with the strip. A camera, mounted with the strip distal end, images the eye interior. A wire is fixed to the strip distal end, so that a predetermined force on the wire causes the tube distal end to bend by a preset angle. A magnetometer at the tube proximal end is configured, when a nonvarying magnetic field traverses it, to provide a signal that, when taken with the preset angle, indicates a camera orientation.

Abstract: A method that includes selectively positioning an ablation catheter system at a treatment site comprising cardiac tissue, ablating cardiac tissue at the treatment site with the ablation catheter system using a power setting of approximately 90 W applied to tissue for approximately four (4) seconds to achieve a target electrode temperature, and achieving approximately zero incidence of steam pop occurrence in both left and right atrial ablations and complete pulmonary vein isolation, by the ablation catheter system, for all patients of a predetermined patient population suffering from paroxysmal atrial fibrillation (PAF).

Abstract: A location pad includes two or more field-generators, one or more tracking elements, and a frame. The field-generators are configured to generate respective magnetic fields at least in a region-of-interest (ROI) of an organ of a patient, for measuring a position of a medical instrument in the ROI. The one or more tracking elements are for registering the location pad with the organ. The frame is coupled with tissue that is at least partially surrounding the organ, and the frame is configured to fix (i) the two or more field-generators at respective positions surrounding at least a portion of the ROI, and (ii) the one or more tracking elements at one or more respective predefined positions on the frame.

Abstract: A location pad includes two or more field-generators, and a frame. The field-generators are configured to generate respective magnetic fields at least in a region-of-interest (ROI) of a patient organ, for measuring a position of a medical instrument in the ROI. The frame is coupled with tissue that is at least partially surrounding the organ and is configured to fix the two or more field-generators at respective positions surrounding the ROI.