Abstract: An optical measurement instrument for living body includes: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit includes a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.

Abstract: There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light. In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

Abstract: The present invention is helpful in improving stability of repeated measurement and can be applied with high reliability for operations of devices for measurement based on brain functions. A module 801 (a sampler) receives measurement data at each of the measuring points based on information of cerebral blood amount sent from an input unit. The information data accumulated in this sampler are processed by filtering at a secondary agent 803 and a tertiary agent 804 and are analyzed. The synthesizer 802 integrates output information of each agent by weighted linear sum and transmits the data as an output data 602 to the device and operates the device.

Abstract: In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

Abstract: To reduce the number of erroneous operations, on an operation apparatus conducting mutually different operations such as opening and closing operations, a concretized human pictogram indicating mutually different state changes such as state changes represented by use of a face with opened eyes and a face with closed eyes associated with operation signals assigned to a pair of operation switches and a pictogram in which the human pictogram is combined with an operation pictogram representing a state in which a door concretizing an operation target to operate in response to an operation signal is opened or is being completely closed are respectively attached to the operation switches disposed adjacent to each other.

Abstract: To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also changing the ratio of irradiated light intensities under the prespecified value.

Abstract: A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to re

Abstract: At each of measurement sites, changes in plural biological data (such as an oxy-Hb signal species and a deoxy-Hb signal species) in a predetermined period are statistically tested independently of each other. By combining results of the plural biological data, the measurement sites are each classified into one out of plural categories. The classified results are each displayed in a single chart. Effective is also a method of setting different activity periods correspondingly to plural Hb signal species, deciding whether or not each of the signal species shows activity or estimating the strength of the signal species, and displaying classification results based on combination of activities of the plural Hb signal species in a single chart. A living body light measuring device using the brain activity analyzing method and displaying method of the invention makes it possible to detect sites where brain activity is generated with a high precision.

Abstract: A living body light measuring device including plural light-radiating devices for radiating light to a head of a subject, plural light-receiving devices for detecting light which is transmitted through the head of the subject after radiation from the light-radiating devices, a calculator for calculating a change of concentration of oxidized and deoxidized hemoglobin in the head of the subject at a measurement point using a pair of each of the plural light-radiating devices and corresponding ones of the light-receiving devices. The calculator decides whether the oxidized hemoglobin concentration change and the deoxidized hemoglobin concentration change are statistically significant at each of the measurement points, and the display displays the decisions regarding the individual measurement points.

Abstract: The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.

Abstract: In a method of marking pictograms, for reducing the number of erroneous operations, on an operation apparatus conducting mutually different operations such as opening and closing operations, a concretized human pictogram indicating mutually different state changes such as state changes represented by use of a face with opened eyes and a face with closed eyes associated with operation signals assigned to a pair of operation switches and a pictogram in which the human pictogram is combined with an operation pictogram representing a state in which a door concretizing an operation target to operate in response to an operation signal is opened or is being completely closed are respectively attached to the operation switches disposed adjacent to each other.

Abstract: An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.

Abstract: In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

Abstract: In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.

Abstract: A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

Abstract: In the past, comparison of mean values or variances measured from multiple subjects with one another has been a mainstream of diagnostic support to be achieved using cerebral activity signals. However, in this case, it is hard to absorb individual differences, and the precision in a diagnostic support technology is low. In order to improve the precision in the diagnostic support technology, the property of data acquired by an optical organism measurement system is utilized in order to create and display information representing a change in the condition of each person. Thus, diagnosis of each person is effectively supported. Measured light signals are used to calculate and record changes in the concentrations of oxidized hemoglobin (Hb), deoxidized Hb, and total Hb respectively.

Abstract: This invention measures cerebral blood volume changes to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its with-time change to thereby estimate and display diseased and dangerous portions based on the evaluation. Briefly, the above-noted object is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.

Abstract: Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.

Abstract: There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light. In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

Abstract: The present invention is helpful in improving stability of repeated measurement and can be applied with high reliability for operations of devices for measurement based on brain functions. A module 801 (a sampler) receives measurement data at each of the measuring points based on information of cerebral blood amount sent from an input unit. The information data accumulated in this sampler are processed by filtering at a secondary agent 803 and a tertiary agent 804 and are analyzed. The synthesizer 802 integrates output information of each agent by weighted linear sum and transmits the data as an output data 602 to the device and operates the device.