Abstract: The present invention provides an optical measurement device of biological tissue having a probe attachable to a moving part of a living body with a high curvature in biophotometry. A member having a high flexibility and a high friction coefficient is disposed on a surface for contact with the living body. In addition, a device for light irradiation and a device for collection of light are fixed with an elastic material for uniform pressure application. The resulting double structure or double layer has solved a problem.

Abstract: There is provided a living body light measuring device capable of monitoring a time curve of a blood substance concentration as time curves of parameters of a signal waveform and judging or analyzing characteristic traits of a subject relevant to the parameters of the signal waveform, wherein a signal processor extracts parameters such as a peak value and latency from a hemoglobin signal waveform measured before and after substance intake of a testee, and generates and displays a time curve graph having a parameter and time respectively as its ordinate and abscissa. Influence of an intake substance upon blood component concentrations and blood flow can be monitored by monitoring the time curves of parameters of the signal waveform. A category processor classifies measurement data into categories, analyzes time curves of a plurality of parameters every category, and displays a result on a result viewer.

Abstract: An input instrument for a living body, using an optical measurement system for the living body, includes first and second light incident units arranged on a head of a living body, and first and second light detectors which are paired with the first and the second light incident units respectively, and which are provided to collect light which passes through the living body based on the light irradiated onto the head of the living body by the light incident means. Measurement signals are obtained by measuring a plurality of regions of the living body by the first and the second light incident units, the first and the second light detectors, and characteristic parameters of the signals of an arbitrary time interval of the measured signals are calculated.

Abstract: An optical measurement instrument for a living body including a first light irradiator for irradiating light from a first irradiation position in a small region as considered as a plan on the surface of a head of a subject into the inside of the head in the region in the direction of depth, a second light irradiator for irradiating light from a second irradiation position in the region into the inside of the head, a first detecting for detecting the first irradiated light to pass through the head in a first detection position in the region, a second detector for detecting the second irradiated light to pass through the head in a second detection position in the region, and a calculator for multiplication or addition of a first signal and a second signal in a calculator.

Abstract: An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.

Abstract: In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method comprising an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program (S1); a process for inputting items of condition including a measurement mode (S2); a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode (S4); a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel (S10); and a process for displaying said signals f

Abstract: The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

Abstract: An optical measurement system for optically measuring a body to be inspected and obtaining an image of a desired item based on information obtained by the measurement includes means for displaying a number of measurement points, means for indicating a light irradiation position and a light detecting position and means for displaying a measurement position and a state of allocating a number to the measurement position. The system further includes means for displaying measuring time sequence data, means for setting a condition of acquiring data, means for displaying a status of acquiring the data, means for instructing control of measurement and means for marking a mark at a position measuring time sequence data.

Abstract: A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

Abstract: In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.

Abstract: A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.

Abstract: In order to provide a compact device easy to handle and adjust for use in bloodless measurement of the glucose concentration, in which the angle of polarization varies in synchronism with the magnetic field modulation, the direction of applying the magnetic field is so arranged as to cross the optical axis.

Abstract: A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

Abstract: Optical measurement that is optimum for improving spatial resolution is accomplished by making it possible to estimate a physical quantity of an object substance to be measured at any point on a subject. When any position to be evaluated, in an image shown in a window 1-1, is pointed and selected a mouse pointer 1-4, the value of the concentration or its change of the object substance at the point is displayed in the display area 1-7 of a window 1-3. The drawings represents an example in which one position is specified and there are two object substances to be measured. The value of the concentration or its change of each object substance to be measured is separately displayed.

Abstract: An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.

Abstract: In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

Abstract: In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

Abstract: In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

Abstract: The invention provides optical technique for measuring metabolism in a living body that can further reduce an error in measurement even if distance between irradiation and detection is fixed. The living body is classified into measurement regions and different measuring wavelengths are set according to the classification. For example, the head is classified into four regions of a parietal region, a frontal region, a temporal region and an occipital region and a wavelength according to each tissue is set in a wavelength selecting system. In measurement, wavelengths according to each measurement region are selected by multiple wavelengths-light radiating means. Besides, for a region having large personal difference, premeasurement is made using plural combinations of wavelengths and wavelengths are selected using a calculated error in measurement as a criterion.

Abstract: An optical measuring apparatus for optically measuring a sample includes a plurality of parts for applying light beams to the sample, a plurality of detecting parts for detecting light beams from the light applying parts which come through the sample, a memory part which receives signals from the detecting parts, converts them into digital signals and stores the digital signals as measuring positions between the light applying part and the light detecting part. Further, there is provided a first display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts on the sample, and a second display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts which are shown on the first display part.