Abstract: Provided is an electrical connection box with a simple configuration that can prevent liquid from running into a housing. An electrical connection box for a vehicle provided with a case member for installing a first fuse includes a removal port formed at a front surface of the case member, the removal port enabling the first fuse to be installed and removed; and a groove formed around the removal port, the groove guiding liquid running down the front surface away from the removal port.

Abstract: A resonator element includes an AT-cut quartz crystal substrate having a first surface that is a front surface and a second surface that is a rear surface with respect to the front surface, the two surfaces extending along the axes X and Z? of a quartz crystal, and further having side surfaces that link the first and second surfaces to each other, a first excitation electrode disposed at the first surface, a first extraction electrode disposed at the first surface and coupled to the first excitation electrode, a second excitation electrode disposed at the second surface, and a second extraction electrode disposed at the second surface and coupled to the second excitation electrode. The side surfaces include a first side surface located at one side of the direction of the axis X, and second and third side surfaces that intersect with the first side surface. At least one of the first and second extraction electrodes is disposed at and extends along the first side surface.

Abstract: A method for manufacturing a vibrator includes: a preparation process of preparing a quartz-crystal wafer including a vibrator and a holding portion, the vibrator including a support portion and a vibration part arranged side by side along a first direction, the holding portion being coupled to one end portion of the support portion in a second direction intersecting the first direction; an adhering process of fixing at least the support portion and the holding portion of the quartz-crystal wafer to a film via an adhesive; and a singulation process of stretching the film along the second direction, and separating and singulating the vibrator from the holding portion.

Abstract: A resonator device includes a resonator element, a container configured to house the resonator element, and a bonding member configured to bond the resonator element and the container to each other, wherein the resonator element has a vibrating part which has a first principal surface provided with a first excitation electrode, a second principal surface provided with a second excitation electrode and having an obverse-reverse relationship with the first principal surface, and a side surface extending in a first direction along a displacement direction of a thickness-shear vibration excited by the first excitation electrode and the second excitation electrode, and which has a longitudinal direction in a second direction as a direction crossing the first direction, a coupling arm extending in the second direction from the side surface of the vibrating part, and a support part which includes a first support arm extending in the first direction from the coupling arm, which extends in the first direction, and whi

Abstract: A vibrator device includes a vibrator element including a vibrator section having a rectangular shape in a plan view, a linkage arm extending from a corner portion of the vibrator section in a first direction, and a support arm extending from the linkage arm in a second direction that intersects with the first direction, a container that houses the vibrator element, and an adhesive member that is shifted from the linkage arm in the second direction, is bonded to the support arm of the vibrator element, and bonds the vibrator element to the container, and an adhesive area of the region where the adhesive member is bonded to the support arm is greater than or equal to 20% of the area of the support arm in the plan view.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: A vibrator includes a vibrator section, a support section, a linkage section, a first excitation electrode that is provided at a first principal surface, a second excitation electrode that is provided at a second principal surface and induces along with the first excitation electrode thickness-shear vibration that vibrates along a direction X, a first support electrode that is provided at the support section and electrically coupled to the first excitation electrode, a second support electrode that is provided at the support section and electrically coupled to the second excitation electrode, a first draw-out wiring line that is drawn from the first excitation electrode along a direction Z and electrically couples the first excitation electrode to the first support electrode, and a second draw-out wiring that is drawn from the second excitation electrode along the direction Z and electrically couples the second excitation electrode to the second support electrode.

Abstract: A vibrator element includes a vibrator section that has a first principal surface, a second principal surface, a first side surface, and a second side surface, a support section that is disposed at a distance from the vibrator section and has a first support side surface facing the first side surface of vibrator section and a second support side surface extending in a direction that intersects with the direction in which the first support side surface extends, and a linkage section that has a first linkage surface coupled to the first side surface and the first support side surface and a second linkage surface coupled to the second side surface and the second support side surface, and the first linkage surface has a configuration in which at least one of a first section coupled to the first side surface and a second section coupled to the first support side surface has a curved surface.

Abstract: The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Abstract: The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

Abstract: A vibrator includes: a vibration element that includes a pair of first excitation electrodes formed at the first vibration portion, a pair of second excitation electrodes formed at the second vibration portion, and a pair of third excitation electrodes formed at the third vibration portion, in which one second excitation electrode of the pair of second excitation electrodes is formed at a first inclined surface that is inclined with respect to two main surfaces, and one third excitation electrode of the pair of third excitation electrodes is formed at a second inclined surface that is inclined with respect to the two main surfaces and the first inclined surface; and a package that houses the vibration element. The vibration element includes a fixing portion to be fixed to the package. The fixing portion is provided between the first vibration portion and the second and third vibration portions.

Abstract: A method for manufacturing a resonator element includes: a substrate preparation step of preparing a substrate; an etching step of performing an etching process on the substrate to form a resonator element, a frame portion, and a holding portion that couples the resonator element and the frame portion; and a break-off step of breaking off the resonator element from the frame portion. The holding portion includes a narrow portion in which a part of a width is narrow. The width of the narrow portion is minimum at a position closer to a resonator element side than at a center of the holding portion. In a cross-sectional view, an angle formed by a side surface of the narrow portion with respect to a flat surface of the holding portion is in a range of 85° or more and 95° or less. The etching process is dry etching.

Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

Abstract: Systems and methods that address an optimized method to improve systems and methods for handling inequality constraints in mixed binary optimization problems on quantum computers and to solve local optima which significantly improves system performance. Embodiments employ an improved methodology that can optimize parameters, determine an optimal slack variable and optimize variational parameters for fixed slack variables. This procedure allows to move out of local minima, solve an optimization and improve the system performance by providing optimal results. These embodiments also extend to variational hybrid quantum/classical algorithms for gate-based quantum computers.

Abstract: A resonator component includes a resonator element which has a rectangular shape having a longitudinal direction set to a first direction and a width direction set to a second direction in a plan view, which is made of a piezoelectric material, and which has a first principal surface, a second principal surface having an obverse-reverse relationship with the first principal surface, and a first side surface and a second side surface which are configured to couple the first principal surface and the second principal surface to each other, and extend in the first direction, a first excitation electrode disposed on the first principal surface, a second excitation electrode disposed on the second principal surface, a first mounting electrode electrically coupled to the first excitation electrode, a second mounting electrode electrically coupled to the second excitation electrode, a first side-surface electrode which extends in the first direction on the first side surface, and is electrically coupled to the first

Abstract: Configuring a quantum computing system to determine a solution to an optimization problem includes encoding the optimization problem in an encoding language to produce an encoded optimization model. The encoded optimization model is transformed into a unconstrained model. The encoded optimization model includes an objective function having one or more terms. The one or more terms are converted to one or more Pauli terms. An Ising Hamiltonian is generated using the one or more terms. The Ising Hamiltonian corresponds to the optimization problem. An instruction indicative of the Ising Hamiltonian is provided to the quantum computing system.

Abstract: A resonator device includes a quartz crystal substrate, a resonator element including a first excitation electrode arranged on a first surface of the quartz crystal substrate, a second excitation electrode arranged on a second surface of the quartz crystal substrate in opposition to the first excitation electrode, and first and second pad electrodes that are arranged on the first surface and are coupled to the first and second excitation electrodes, a base including a substrate and first and second interconnects arranged on the substrate, a first bonding member bonding the first pad electrode to the first interconnect, and a second bonding member bonding the second pad electrode to the second interconnect. The first and second bonding members are arranged such that a first imaginary line that passes through a centroid of the resonator element and is parallel to an X axis is interposed between the first and second bonding members.

Abstract: A vibrator includes: a vibration element that includes a pair of first excitation electrodes formed at the first vibration portion, a pair of second excitation electrodes formed at the second vibration portion, and a pair of third excitation electrodes formed at the third vibration portion, in which one second excitation electrode of the pair of second excitation electrodes is formed at a first inclined surface that is inclined with respect to two main surfaces, and one third excitation electrode of the pair of third excitation electrodes is formed at a second inclined surface that is inclined with respect to the two main surfaces and the first inclined surface; and a package that houses the vibration element. The vibration element includes a fixing portion to be fixed to the package. The fixing portion is provided between the first vibration portion and the second and third vibration portions.

Abstract: A vibrating element includes a quartz crystal substrate having a first vibrating portion having a pair of first excitation electrodes, a second vibrating portion having a pair of second excitation electrodes, and a third vibration portion having a pair of third excitation electrodes, in which at least one second excitation electrode of the pair of second excitation electrodes is formed into a first inclined surface inclined with respect to both main surfaces of the quartz crystal substrate, and at least one third excitation electrode of the pair of third excitation electrodes is formed into a second inclined surface inclined with respect to both the main surfaces and the first inclined surface.

Abstract: The present inventors have successfully prepared an antibody Fc region dimer that has binding activity against each of an antigen and Fc?R, but does not bind to the antigen and the Fc?R at the same time, and a polypeptide comprising the Fc region dimer. The present invention enables the preparation of a multispecific binding polypeptide capable of avoiding an adverse reaction that may be caused by its binding to an antigen and Fc?R at the same time. Thus, the present invention provides a polypeptide suitable as a drug.