Abstract: A controller of an information processing device displays, on a display, a display screen having a first display region that displays a list of files, and a second display region that displays an operation button; selects one or more files from among the displayed list of files; and in response to selection of the operation button after a file is selected, renames the file in accordance with additional information associated with the operation button.

Abstract: A vibration element includes: a quartz crystal substrate having a first vibration part and a second vibration part; a pair of first excitation electrodes formed at two main surfaces of the quartz crystal substrate, at the first vibration part; and a pair of second excitation electrodes formed in such a way as to sandwich the second vibration part in a direction of thickness of the quartz crystal substrate, at the second vibration part. At least one second excitation electrode of the pair of second excitation electrodes is formed at an inclined surface inclined to at least one of the two main surfaces.

Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

Abstract: A resonator element includes a first electrode that is installed on a resonance portion of one of main surfaces positioned on the front and rear surfaces of a substrate, and a second electrode that is installed on the resonance portion of the other of the main surfaces, an outer shape of the substrate includes a first side surface and a second side surface, are arranged in a second direction intersecting the first direction, the first side surface and the second side surface respectively include an inclined surface, the first electrode includes a first lead electrode installed on the inclined surface of the first side surface, a second electrode includes the second lead electrode installed on the inclined surface of the second side surface, and an angle formed between the inclined surface and the main surface is equal to or greater than 52° and equal to or less than 62°.

Abstract: The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan, and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.

Abstract: A physical quantity detecting device includes a vibrating element and a charge amplifier. The vibrating element includes a first detection electrode, a second detection electrode, a third detection electrode, and a fourth detection electrode. The first and fourth detection electrodes have the same electrical polarity, the second and third detection electrodes have the same electrical polarity, and the first and second detection electrodes have opposite electrical polarities. The first and fourth detection electrodes are connected to the charge amplifier, and the second and third detection electrodes are connected to the charge amplifier.

Abstract: Configuring a quantum computing system to determine a solution to an optimization problem includes encoding the optimization problem in an encoding language to produce an encoded optimization model. The encoded optimization model is transformed into a unconstrained model. The encoded optimization model includes an objective function having one or more terms. The one or more terms are converted to one or more Pauli terms. An Ising Hamiltonian is generated using the one or more terms. The Ising Hamiltonian corresponds to the optimization problem. An instruction indicative of the Ising Hamiltonian is provided to the quantum computing system.

Abstract: A vibration device including a vibrator, a circuit component, a relay substrate disposed between the vibrator and the circuit component, a package that accommodates the vibrator, the circuit component, and the relay substrate, a first metal bump that joins the circuit component to the package, a second metal bump that joins the relay substrate to the circuit component, and a third metal bump that joins the vibrator to the relay substrate.

Abstract: A resonator element includes a quartz crystal substrate including a supporting section, a resonating section, and a coupling section coupling the supporting section and the resonating section and having thickness smaller than the thickness of the supporting section, the supporting section including a first principal plane and a first side surface coupling the first principal plane and the coupling section, a first excitation electrode disposed in the resonating section, a second excitation electrode disposed in the resonating section and overlapping the first excitation electrode via the resonating section, and first and second pad electrodes including portions disposed on the first principal plane, the first and second pad electrodes being electrically coupled to the first and second excitation electrodes.

Abstract: A resonator element includes a quartz crystal substrate including a first surface along an X axis which is an electrical axis, a second surface along the X axis, and a side surface, a first excitation electrode, a second excitation electrode, a first coupling electrode, a second coupling electrode, a first extraction electrode that couples the first excitation electrode and the first coupling electrode, and a second extraction electrode that couples the second excitation electrode and the second coupling electrode. In plan view, a virtual extension region is obtained by extending the first excitation electrode along the X axis.

Abstract: A resonator device includes a quartz crystal substrate, a resonator element including a first excitation electrode arranged on a first surface of the quartz crystal substrate, a second excitation electrode arranged on a second surface of the quartz crystal substrate in opposition to the first excitation electrode, and first and second pad electrodes that are arranged on the first surface and are coupled to the first and second excitation electrodes, a base including a substrate and first and second interconnects arranged on the substrate, a first bonding member bonding the first pad electrode to the first interconnect, and a second bonding member bonding the second pad electrode to the second interconnect. The first and second bonding members are arranged such that a first imaginary line that passes through a centroid of the resonator element and is parallel to an X axis is interposed between the first and second bonding members.

Abstract: Swap insertion in mapping logical qubits on a quantum circuit is performed by obtaining an operation sequence including a plurality of operations to be executed on a quantum circuit. The quantum circuit including a plurality of physical qubits and a plurality of couplings. Finding a blocking set of operations including leading unresolved operation in the operation sequence. Calculating a first coupling score for each coupling of the plurality of couplings based on total reduction of shortest path lengths of a plurality of unresolved operations of the plurality of operations Selecting a coupling based on the first coupling score of each coupling. Updating the blocking set by removing any leading unresolved operations from the blocking set that can be performed after swapping a pair of logical qubits stored in a pair of physical qubits connected by the selected coupling.

Abstract: Swap insertion in mapping logical qubits on a quantum circuit is performed by obtaining an operation sequence including a plurality of operations to be executed on a quantum circuit. The quantum circuit including a plurality of physical qubits and a plurality of couplings. Finding a blocking set of operations including leading unresolved operation in the operation sequence. Calculating a first coupling score for each coupling of the plurality of couplings based on total reduction of shortest path lengths of a plurality of unresolved operations of the plurality of operations Selecting a coupling based on the first coupling score of each coupling. Updating the blocking set by removing any leading unresolved operations from the blocking set that can be performed after swapping a pair of logical qubits stored in a pair of physical qubits connected by the selected coupling.

Abstract: The present inventors have found that when screening for cyclic peptide compounds that can specifically bind to a target molecule, the use of a library including cyclic peptide compounds having a long side chain in the cyclic portion can improve the hit rate for cyclic peptide compounds that can specifically bind to the target molecule. Meanwhile, the present inventors have found that tryptophan and tyrosine residues, which have conventionally been used in oral low molecular-weight pharmaceuticals and are amino acid residues having an indole skeleton or a hydroxyphenyl group, are not suitable for peptides intended to attain high membrane permeability.

Abstract: A controller of an information processing device displays, on a display, a display screen having a first display region that displays a list of files, and a second display region that displays an operation button; selects one or more files from among the displayed list of files; and in response to selection of the operation button after a file is selected, renames the file in accordance with additional information associated with the operation button.

Abstract: A light receiving element has a configuration including a silicon substrate, a photodiode, an amplifier circuit adapted to amplify an output signal from the photodiode, and a blocking section disposed between the photodiode and the amplifier circuit and connected to the ground, wherein the photodiode, the amplifier circuit and the blocking section are provided to the silicon substrate.

Abstract: A light receiving element includes a silicon substrate, a photodiode, an amplifier circuit adapted to amplify an output signal from the photodiode, and a light blocking section adapted to cover at least a part of the amplifier circuit to block light, and the photodiode, the amplifier circuit and the light blocking section are provided to the silicon substrate.