Patents by Inventor Atsushi Miyajima
Atsushi Miyajima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12128072Abstract: The present invention pertains to hepatocytes, liver progenitor cells, cholangiocytes, liver sinusoidal endothelial progenitor cells, liver sinusoidal endothelial cells, hepatic stellate progenitor cells, hepatic stellate cells, and liver cellular tissue models, as well as to methods for preparing these cells. The present invention also pertains to a cell fraction comprising liver progenitor cells, liver sinusoidal endothelial progenitor cells, or hepatic stellate progenitor cells. The present invention also pertains to a pharmaceutical composition or kit comprising the above-mentioned cells, a liver cellular tissue model, or a cell fraction.Type: GrantFiled: November 15, 2019Date of Patent: October 29, 2024Assignee: The University of TokyoInventors: Atsushi Miyajima, Taketomo Kido, Yuta Koui, Ayaka Kobayashi
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Publication number: 20220257666Abstract: It is an object of the present invention to provide a method for preparing or separating pancreatic progenitor cells (or a group of pancreatic progenitor cells) that do not contain undifferentiated cells and efficiently differentiate into pancreatic islet cells. More specifically, the present invention relates to: pancreatic progenitor cells that appear in the process of differentiation of stem cells into pancreatic islet cells, which are characterized in that the pancreatic progenitor cells are positive to CD82; an agent for treating blood glucose level impairment, wherein the agent comprises the pancreatic progenitor cells; and a method for preparing pancreatic progenitor cells, wherein the method comprises separating CD82-positive cells.Type: ApplicationFiled: June 26, 2020Publication date: August 18, 2022Applicant: The University of TokyoInventors: Atsushi MIYAJIMA, Ami WATANABE
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Patent number: 11156536Abstract: A loss tangent tan ? is the ratio between a storage modulus and a loss modulus calculated from a stress when vibrations of a predetermined frequency are applied to a rubber member. When evaluating a shock resistance performance of the rubber member using an elongation at break Eb, a tensile strength at break TSb, and a loss tangent tan ? of the rubber member, a speed of an impact applied under use conditions of the rubber member is matched with a maximum speed of vibrations. As a result, the shock resistance performance can be evaluated using a value of the loss tangent tan ? corresponding to an impact actually applied to the rubber member, and it is possible to improve the accuracy of the shock resistance performance evaluation.Type: GrantFiled: December 14, 2017Date of Patent: October 26, 2021Assignee: The Yokohama Ruber Co., Ltd.Inventor: Atsushi Miyajima
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Patent number: 11001449Abstract: A conveyor belt includes core layers made of fabric disposed between an upper cover rubber and a lower cover rubber. At least one core layer has a strength in the belt width direction ranging from 30% to 70% of a strength in the belt longitudinal direction.Type: GrantFiled: June 16, 2016Date of Patent: May 11, 2021Inventors: Etsuko Suzuki, Atsushi Miyajima
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Patent number: 10704999Abstract: A conveyor belt 10 is formed with a belt core body 14 covered by a cover rubber 12. The cover rubber 12 is formed with a shock resistance performance evaluation index, i.e., the product of an elongation at break Eb, a tensile strength at break TSb, and a loss tangent tan ? of 6000 or greater. The loss tangent tan ? is the ratio between a storage modulus and a loss modulus calculated from a stress when vibrations of a predetermined frequency are applied to cover rubber 12. The measurement conditions of the loss tangent tan ? are determined on the basis of a speed of an impact applied under the use conditions of the conveyor belt 10.Type: GrantFiled: December 14, 2017Date of Patent: July 7, 2020Assignee: The Yokohama Rubber Co., Ltd.Inventor: Atsushi Miyajima
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Publication number: 20200200662Abstract: A loss tangent tan ? is the ratio between a storage modulus and a loss modulus calculated from a stress when vibrations of a predetermined frequency are applied to a rubber member. When evaluating a shock resistance performance of the rubber member using an elongation at break Eb, a tensile strength at break TSb, and a loss tangent tan ? of the rubber member, a speed of an impact applied under use conditions of the rubber member is matched with a maximum speed of vibrations. As a result, the shock resistance performance can be evaluated using a value of the loss tangent tan ? corresponding to an impact actually applied to the rubber member, and it is possible to improve the accuracy of the shock resistance performance evaluation.Type: ApplicationFiled: December 14, 2017Publication date: June 25, 2020Inventor: Atsushi MIYAJIMA
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Publication number: 20200188444Abstract: The present invention pertains to hepatocytes, liver progenitor cells, cholangiocytes, liver sinusoidal endothelial progenitor cells, liver sinusoidal endothelial cells, hepatic stellate progenitor cells, hepatic stellate cells, and liver cellular tissue models, as well as to methods for preparing these cells. The present invention also pertains to a cell fraction comprising liver progenitor cells, liver sinusoidal endothelial progenitor cells, or hepatic stellate progenitor cells. The present invention also pertains to a pharmaceutical composition or kit comprising the above-mentioned cells, a liver cellular tissue model, or a cell fraction.Type: ApplicationFiled: November 15, 2019Publication date: June 18, 2020Applicant: The University of TokyoInventors: Atsushi Miyajima, Taketomo Kido, Yuta Koui, Ayaka Kobayashi
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Publication number: 20200110011Abstract: A conveyor belt 10 is formed with a belt core body 14 covered by a cover rubber 12. The cover rubber 12 is formed with a shock resistance performance evaluation index, i.e., the product of an elongation at break Eb, a tensile strength at break TSb, and a loss tangent tan ? of 6000 or greater. The loss tangent tan ? is the ratio between a storage modulus and a loss modulus calculated from a stress when vibrations of a predetermined frequency are applied to cover rubber 12. The measurement conditions of the loss tangent tan ? are determined on the basis of a speed of an impact applied under the use conditions of the conveyor belt 10.Type: ApplicationFiled: December 14, 2017Publication date: April 9, 2020Inventor: Atsushi MIYAJIMA
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Publication number: 20190093082Abstract: An object is to provide a method of differentiating pluripotent stem cells. A method of differentiating pluripotent stem cells, the method comprising steps of: seeding the pluripotent stem cells in a container provided with seeding medium! differentiating the pluripotent stem cells in the container; transferring the pluripotent stem cells from the container into a chamber of a bioreactor when the pluripotent stem cells reach their progenitor stage; and maturing the pluripotent stem cells in the chamber, wherein a floor of the chamber includes a concave and a convex, fluid of medium flows in the chamber and oxygen is supplied into the chamber.Type: ApplicationFiled: March 7, 2016Publication date: March 28, 2019Inventors: Eric Leclerc, Yasuyuki Sakai, Keiichi Kimura, Atsushi Miyajima, Taketomo Kido
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Patent number: 10239695Abstract: A conveyor belt includes an upper cover rubber and a lower cover rubber disposed above and below a core layer; and a protective fiber layer made from high strength fiber disposed at least in a central portion of the upper cover rubber in a belt width direction and extending continuously in a belt longitudinal direction; an elastic modulus E of the protective fiber layer in the belt longitudinal direction being a low elastic modulus E1 equal to or less than a predetermined value when a tension in the belt longitudinal direction acting on the conveyor belt is equal to or less than a setting tension Ts, and being a high elastic modulus E2 higher than the low elastic modulus E1 when a predetermined high tension higher than the setting tension Ts is acting on the conveyor belt.Type: GrantFiled: June 16, 2016Date of Patent: March 26, 2019Assignee: The Yokohama Rubber Co., LTD.Inventors: Atsushi Miyajima, Etsuko Suzuki
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Patent number: 10160600Abstract: The present technology provides a conveyor belt. An upper cover rubber and a lower cover rubber are respectively disposed above and below a core layer so as to sandwich the core layer, which core layer is composed of a plurality of steel cords extending side by side in parallel. The outer diameter of the steel cords is not less than 0.35 mm and not greater than 6.0 mm, and the side-by-side pitch P of the steel cords is greater than 0.35 mm and not greater than 7.0 mm. The steel cords are embedded extending in the longitudinal direction of the conveyor belt.Type: GrantFiled: May 11, 2016Date of Patent: December 25, 2018Assignee: The Yokohama Rubber Co., LTD.Inventors: Gang Hou, Ryotaro Suefuji, Atsushi Miyajima
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Publication number: 20180194560Abstract: A conveyor belt includes an upper cover rubber and a lower cover rubber disposed above and below a core layer; and a protective fiber layer made from high strength fiber disposed at least in a central portion of the upper cover rubber in a belt width direction and extending continuously in a belt longitudinal direction; an elastic modulus E of the protective fiber layer in the belt longitudinal direction being a low elastic modulus E1 equal to or less than a predetermined value when a tension in the belt longitudinal direction acting on the conveyor belt is equal to or less than a setting tension Ts, and being a high elastic modulus E2 higher than the low elastic modulus E1 when a predetermined high tension higher than the setting tension Ts is acting on the conveyor belt.Type: ApplicationFiled: June 16, 2016Publication date: July 12, 2018Inventors: Atsushi Miyajima, Etsuko Suzuki
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Publication number: 20180194559Abstract: A conveyor belt includes core layers made of fabric disposed between an upper cover rubber and a lower cover rubber. At least one core layer has a strength in the belt width direction ranging from 30% to 70% of a strength in the belt longitudinal direction.Type: ApplicationFiled: June 16, 2016Publication date: July 12, 2018Inventors: Etsuko Suzuki, Atsushi Miyajima
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Patent number: 10011428Abstract: A coating rubber composition for a conveyer belt, comprising 15 to 75 parts by mass of carbon black having a nitrogen adsorption specific surface area of 50 m2/g or less, 25 to 100 parts by mass of calcium carbonate and 40 parts or less by mass of an oil per 100 parts by mass of blended rubber comprising of natural rubber and at least one of either butadiene rubber or SBR. The above coating rubber composition for conveyer belts can improve not only the peel force which is a criterion of adhesiveness with the canvas cloth but also the power-saving capability of the conveyer belt while maintaining the durability thereof. Further, compounding of silica in an amount of 5 to 20 parts by mass can achieve a sufficient rubber attachability onto the canvas cloth when over-vulcanized, while maintaining the peel force when subjected to normal vulcanization.Type: GrantFiled: April 10, 2015Date of Patent: July 3, 2018Assignee: The Yokohama Rubber Co., Ltd.Inventors: Hidehiro Sasakuma, Ryotaro Suefuji, Gang Hou, Atsushi Miyajima
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Publication number: 20180148263Abstract: The present technology provides a conveyor belt. An upper cover rubber and a lower cover rubber are respectively disposed above and below a core layer so as to sandwich the core layer, which core layer is composed of a plurality of steel cords extending side by side in parallel. The outer diameter of the steel cords is not less than 0.35 mm and not greater than 6.0 mm, and the side-by-side pitch P of the steel cords is greater than 0.35 mm and not greater than 7.0 mm. The steel cords are embedded extending in the longitudinal direction of the conveyor belt.Type: ApplicationFiled: May 11, 2016Publication date: May 31, 2018Inventors: Gang Hou, Ryotaro Suefuji, Atsushi Miyajima
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Publication number: 20180147242Abstract: The present invention pertains to hepatocytes, liver progenitor cells, cholangiocytes, liver sinusoidal endothelial progenitor cells, liver sinusoidal endothelial cells, hepatic stellate progenitor cells, hepatic stellate cells, and liver cellular tissue models, as well as to methods for preparing these cells. The present invention also pertains to a cell fraction comprising liver progenitor cells, liver sinusoidal endothelial progenitor cells, or hepatic stellate progenitor cells. The present invention also pertains to a pharmaceutical composition or kit comprising the above-mentioned cells, a liver cellular tissue model, or a cell fraction.Type: ApplicationFiled: March 16, 2016Publication date: May 31, 2018Applicant: The University of TokyoInventors: Atsushi Miyajima, Taketomo Kido, Yuta Koui, Ayaka Kobayashi
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Publication number: 20180008749Abstract: An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing mesothelial cells; an adhesion preventing method and organ regeneration promoting method each using the cell sheet containing mesothelial cells.Type: ApplicationFiled: September 20, 2017Publication date: January 11, 2018Inventors: Atsushi MIYAJIMA, Natsuko Inagaki, Fuyuki Inagaki, Norihiro Kokudo
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Patent number: 9850069Abstract: The present technology provides a rubber composition containing: a diene-based rubber containing a natural rubber and a butadiene rubber; a carbon black 1; and a carbon black 2. A nitrogen adsorption specific surface area of the carbon black 1 is from 60 to 100 m2/g; a dibutyl phthalate oil absorption of the carbon black 1 is 120 cm3/100 g or less; a nitrogen adsorption specific surface area of the carbon black 2 is from 20 to 40 m2/g; a dibutyl phthalate oil absorption of the carbon black 2 is from 70 to 95 cm3/100 g; and a total amount of the carbon black 1 and the carbon black 2 being from 25 to 50 parts by mass per 100 parts by mass of the diene-based rubber.Type: GrantFiled: May 22, 2015Date of Patent: December 26, 2017Assignee: The Yokohama Rubber Co., LTD.Inventors: Hidehiro Sasakuma, Ryotaro Suefuji, Gang Hou, Atsushi Miyajima
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Patent number: 9828181Abstract: A rubber-reinforcing steel cord embedded in a rubber product has a stranded structure including a core strand, and a plurality of sheath strands intertwined around an outer circumferential surface of the core strand; wherein a lubricant is provided between wires that constitute the core strand.Type: GrantFiled: June 5, 2015Date of Patent: November 28, 2017Assignee: The Yokohama Rubber Co., LTD.Inventors: Gang Hou, Atsushi Miyajima, Ryotaro Suefuji, Hidehiro Sasakuma
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Patent number: 9783367Abstract: A conveyor belt includes a core layer disposed between an upper cover rubber layer and a lower cover rubber layer. The core layer is configured from a plurality of steel cords covered by cushioning rubber and arranged in parallel. The rubber that forms the lower cover rubber layer is a low loss rubber that has a loss factor tan? of 0.07 or less at a frequency of 10 Hz, 2% dynamic strain, and temperature of 20° C. The maximum thickness of the cushioning rubber is reduced to not more than ? the nominal diameter of the steel cords.Type: GrantFiled: August 23, 2013Date of Patent: October 10, 2017Assignee: The Yokohama Rubber Co., LTD.Inventors: Atsushi Miyajima, Ryotaro Suefuji, Hidehiro Sasakuma, Gang Hou