Patents by Inventor Atsushi Miyajima

Atsushi Miyajima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of detecting and seperating of undifferentiated liver cellss using dlk
    Publication number: 20040152095
    Abstract: It was discovered that a membrane protein dlk (delta-like) is specifically expressed on the surfaces of fetal hepatic cells. We succeeded in purifying undifferentiated hepatic cells including hepatic stem cells to high purify from mouse fetal liver using an antibody to dlk protein. The obtained fetal hepatic cells included hepatic stem cells having bipotency. The present invention provides a marker molecule of hepatic cells, and a method for detecting undifferentiated hepatic cells utilizing this molecule. The present invention also provides a method for separating undifferentiated hepatic cells utilizing this marker molecule, and the undifferentiated hepatic cells separated by this method. By using the method of the present invention, hepatic stem cells may be purified simply to high concentration. The undifferentiated hepatic cells obtained by the present invention may be used for regenerative medicine and artificial liver.
    Type: Application
    Filed: January 13, 2004
    Publication date: August 5, 2004
    Inventors: Naoki Tanimizu, Atsushi Miyajima
  • Mammalian chemokine reagents
    Publication number: 20030130494
    Abstract: A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: November 13, 2002
    Publication date: July 10, 2003
    Inventors: Daniel J. Dairaghi, Takahiko Hara, Atsushi Miyajima, Thomas J. Schall, Wei Wang, Akihiko Yoshimura
  • Mammalian chemokine reagents
    Patent number: 6512103
    Abstract: A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: January 28, 2003
    Assignee: Schering Corporation
    Inventors: Daniel J. Dairaghi, Takahiko Hara, Atsushi Miyajima, Thomas J. Schall, Wei Wang, Akihiko Yoshimura
  • Human GM-CSF receptor component
    Patent number: 5705611
    Abstract: Nucleic acids encoding the .beta.-chain of the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, as well as the .beta.-chain itself, are provided. The .beta.-chain may be expressed with the .alpha.-chain in cellular hosts to form compositions useful in screening agonists and antagonists of human GM-CSF.
    Type: Grant
    Filed: January 7, 1993
    Date of Patent: January 6, 1998
    Assignee: Schering Corporation
    Inventors: Kazuhiro Hayashida, Toshio Kitamura, Atsushi Miyajima
  • Human interleukin-3 receptor component
    Patent number: 5639605
    Abstract: Nucleic acids encoding the .alpha. chain of the human interleukin-3 (IL-3) receptor, as well as the .alpha. chain itself, are provided. The .alpha. chain may be expressed with the .beta. chain in cellular hosts to form compositions useful in screening agonists and antagonists of human IL-3.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: June 17, 1997
    Assignee: Schering Corporation
    Inventors: Toshio Kitamura, Atsushi Miyajima
  • Human interleukin-3 receptor .alpha. subunit
    Patent number: 5541063
    Abstract: The present invention relates to the isolation and cloning of the .alpha.-chain of the human IL-3 receptor, which, when expressed together with the .beta.-chain of the human IL-3 receptor, forms a high affinity receptor for human IL-3. The invention further relates to a method for detecting agonists and antagonists of human IL-3 by the use of a cellular host expressing genes for the .alpha.- and .beta.-chains of the human IL-3 receptor.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: July 30, 1996
    Assignee: Schering Corporation
    Inventors: Toshio Kitamura, Atsushi Miyajima
  • DNA encoding subunits of a high affinity GM-CSF receptor
    Patent number: 5112961
    Abstract: Nucleic acids encoding the .beta. chain of the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, as well as the .beta. chain itself, are provided. The .beta. chain may be expressed with the .alpha. chain in cellular hosts to form compositions useful in screening agonists and antagonists of human GM-CSF.
    Type: Grant
    Filed: July 18, 1990
    Date of Patent: May 12, 1992
    Assignee: Schering Corporation
    Inventors: Kazuhiro Hayashida, Toshio Kitamura, Atsushi Miyajima