Abstract: The present invention relates to granzyme B variants with increased protease activities and/or increased resistance against inhibitors; polynucleotides encoding the granzyme B variants; cells expressing the granzyme B variants; pharmaceutical compositions containing cells expressing the granzyme B variants; and pharmaceutical compositions containing the granzyme B variants. In some embodiments, the pharmaceutical compositions may be used in combination with cells expressing chimera receptors and/or antigen-binding molecules.

Abstract: An electric motor for reducing eddy current loss including an armature; a field element or permanent magnet as a magnetic source; and a shaft rotating together with the armature or field element. The permanent includes magnet particles bound together by a binder resin, and has a degree of electric resistance anisotropy (?1/?2) of 2 or more. The first electric resistivity (?1) is measured in an axial direction and a second electric resistivity (?2) is measured in a direction perpendicular to the axial direction. The bonded magnet is, for example, a compression-molded bonded magnet that contains 93% to 98.5% of the magnet particles, and the first electric resistivity is 300 ??m or more. When the compression-molded bonded magnet whose compression direction is arranged along the axial direction is used as a field source, the eddy current loss occurring in the compression-molded bonded magnet can be efficiently reduced.

Abstract: By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.

Abstract: Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

Abstract: By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.

Abstract: Multi specific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity are provided. Since the provided molecules show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce pharmaceutical compositions for treating or preventing various cancers.

Abstract: A vehicle includes: a steering wheel arranged at a vehicle front side of a driver's seat; a center display unit provided at a vehicle front side of the steering wheel, and configured to display information toward the driver's seat; a side display unit provided at one or both sides, in a vehicle width direction, of the center display unit, being inclined in a direction toward a vehicle rear side progressively away from the center display unit in plan view, and configured to display information toward the driver's seat; and an operation unit provided at the side display unit and configured to operate a vehicle onboard device.

Abstract: An electric motor for reducing eddy current loss including an armature; a field element or permanent magnet as a magnetic source; and a shaft rotating together with the armature or field element. The permanent includes magnet particles bound together by a binder resin, and has a degree of electric resistance anisotropy (?1/?2) of 2 or more. The first electric resistivity (?1) is measured in an axial direction and a second electric resistivity (?2) is measured in a direction perpendicular to the axial direction. The bonded magnet is, for example, a compression-molded bonded magnet that contains 93% to 98.5% of the magnet particles, and the first electric resistivity is 300 ??m or more. When the compression-molded bonded magnet whose compression direction is arranged along the axial direction is used as a field source, the eddy current loss occurring in the compression-molded bonded magnet can be efficiently reduced.

Abstract: Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

Abstract: Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

Abstract: Novel multi specific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

Abstract: A display device includes a display unit, a pen position acquiring unit that acquires a contact position of the electronic pen on the display unit, or a proximity position of the electronic pen on the display unit, a display controller that displays on the display unit a trace of contact positions, a touch sensing unit that senses a touch position on the display unit, and a controller that sets the acquired proximity position of the electronic pen as a reference position. In a case where the touch sensing unit senses the touch position, the controller performs a process of erasing a display presented by input with a pen, when the sensed touch position is within a predetermined range from the reference position, and executes a process different from the process of erasing a display, when the sensed touch position is outside the predetermined range.

Abstract: A display device including a display unit that displays an image; an operation detection unit that detects designated positions on the display unit respectively designated by two or more fingers of an operator; an operation analysis unit that determines, when the operation detection unit detects that the designated positions are moving in parallel in a first region of the display unit, a position of a second region newly generated in the first region and a display direction of an image displayed in the second region, based on the designated positions and a direction of movement of the designated positions; and a display control unit that controls the display unit to display an image in the second region, according to the position of the second region and the display direction of the image displayed in the second region determined by the operation analysis unit.

Abstract: An information processing apparatus 10a according to the present disclosure includes: a touchscreen panel 14 on which video is displayed and which accepts an operation that has been performed by a user; a detector 21 which detects the operation that has been performed by the user on the touchscreen panel 14; and a processor 20 which performs processing in response to the operation. If the user has performed the operation using a polyhedron input interface device 10b which has a plurality of sides in mutually different shapes, the detector 21 detects the shape of an area in which the input interface device 10b is in contact with the touchscreen panel to determine which side of the polyhedron has been used to perform the operation, and the processor 20 carries out processing that is associated with the side that has been used.

Abstract: By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.

Abstract: A display device in which continuity of content displayed on a screen is maintained between before and after a rotation of the screen, including: a display screen which is fixed to the display device and displays a partial region of an image; an operation detecting unit which specifies a position in the partial region of the image displayed on the display screen; a rotation detecting unit which detects rotation information which indicates a rotation of the display device in a plane including the display screen; and a display image determining unit which updates display content on the display screen to display the partial region of the image after the rotation on the display screen by rotating, based on the rotation information detected by the detecting unit, the partial region of the image around the position specified by the specifying unit.

Abstract: An information processing device for providing a program selected on the basis of a predetermined theme among recorded programs and programs to be received to a user. A special program is generated by selecting a predetermined program on the basis of a predetermined theme such as ‘person of the today’, ‘hot drama’, among recorded programs and programs to be received to a user and the contents of the selected program is displayed on a screen as information of a recommendation program. The contents of the special program are changed according to preference of the user, a displaying time of the screen, and setting by the user.

Abstract: A communication device for transmitting data to an other communication device via a transmission channel, includes a communication characteristic acquisition section which acquires a communication characteristic of the transmission channel, and a frame length control section which controls a frame length of a communication frame storing the data based on the communication characteristic of the transmission channel.