Abstract: Provided are: an agent for promoting growth hormone-secretion, containing a milk-derived basic protein fraction as an active ingredient, with the promotion of growth hormone-secretion being mediated by the promotion of secretion of ghrelin having an effect for promoting growth hormone-secretion; and a method of promoting the secretion of ghrelin by using a milk-derived basic protein fraction. The agent for promoting growth hormone-secretion may be ingested on a daily basis and is highly safe even with its ingestion for a long period.

Abstract: A network relay apparatus which conducts data transfer by using a plurality of network LSIs includes a transfer engine unit having at least two network LSIs and a central control unit which controls the operation state of the network relay apparatus. The transfer engine unit includes the network LSIs capable of changing over at least one of a clock and an operation which differ every function block, a load judgment unit for judging a load laid upon each of function blocks in the network LSI, and a frequency voltage control unit for individually changing over at least one of the clock and operation voltage supplied to each function block on the basis of the load judged by the load judgment unit.

Abstract: A network relay apparatus which conducts data transfer by using a plurality of network LSIs includes a transfer engine unit having at least two network LSIs and a central control unit which controls the operation state of the network relay apparatus. The transfer engine unit includes the network LSIs capable of changing over at least one of a clock and an operation which differ every function block, a load judgment unit for judging a load laid upon each of function blocks in the network LSI, and a frequency voltage control unit for individually changing over at least one of the clock and operation voltage supplied to each function block on the basis of the load judged by the load judgment unit.

Abstract: A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

Abstract: Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.

Abstract: Disclosed is an osteoblast differentiation promoting and osteoclast differentiation inhibiting agent which comprises a milk protein fraction having the following characteristics (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 75,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 13 to 15 wt % in the constitutional amino acid composition, and has a basic amino acid/acidic amino acid of 0.5 to 0.7; and (4) the milk protein fraction has an osteoblast differentiation promoting effect and an osteoclast differentiation inhibiting.

Abstract: A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.

Abstract: Disclosed is an osteoclastogenesis inhibitory agent which comprises a milk protein fraction having the following properties (1) to (4) and the agent is excellent in an osteoclastogenesis inhibitory effect and useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 80,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 16 to 18 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.65 to 0.85; and (4) the milk protein fraction has an osteoclastogenesis inhibitory effect .

Abstract: It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.

Abstract: The production of RANKL may be inhibited by orally ingesting a milk-derived basic protein. Thus, a RANKL production inhibitor containing a milk-derived basic protein fraction as an active ingredient; a therapeutic agent for a metabolic bone disease and a therapeutic agent for an immune disease each containing the RANKL production inhibitor; and a food/beverage and a feed each containing a specified amount of the RANKL production inhibitor and being characterized by inhibiting the production of RANKL have a remarkable effect of inhibiting the production of RANKL, can be ingested on a daily basis, and exhibit high safety even when being ingested over a long period.

Abstract: Provided are: an agent for promoting growth hormone-secretion, containing a milk-derived basic protein fraction as an active ingredient, with the promotion of growth hormone-secretion being mediated by the promotion of secretion of ghrelin having an effect for promoting growth hormone-secretion; and a method of promoting the secretion of ghrelin by using a milk-derived basic protein fraction. The agent for promoting growth hormone-secretion may be ingested on a daily basis and is highly safe even with its ingestion for a long period.

Abstract: The present invention relates to a peptide that is derived from a milk protein and has an antioxidative effect, an antioxidant that includes the peptide as an active ingredient, and an antioxidative food, drink, or feed that includes the peptide. The present invention also relates to a peptide that is derived from a milk protein and has an adiponectin production promotion effect, an adiponectin production promoter that includes the peptide as an active ingredient, and an adiponectin production promotion food, drink, or feed that includes the peptide. The present invention further relates to a blood adiponectin level increase promotion and/or decrease inhibition agent that includes a component contained in cheese as an active ingredient, and a blood adiponectin level increase promotion and/or decrease inhibition food or drink that includes a component contained in cheese.

Abstract: A network relay apparatus which conducts data transfer by using a plurality of network LSIS includes a transfer engine unit having at least two network LSIs and a central control unit which controls the operation state of the network relay apparatus. The transfer engine unit includes the network LSIs capable of changing over at least one of a clock and an operation which differ every function block, a load judgment unit for judging a load laid upon each of function blocks in the network LSI, and a frequency voltage control unit for individually changing over at least one of the clock and operation voltage supplied to each function block on the basis of the load judged by the load judgment unit.

Abstract: This invention provides a data transfer control device for carrying out data transfer using a plurality of transfer resources. The data transfer control device comprises a transfer resource management portion that set the plurality of transfer resources to either one of a transfer-enabled state whereby data transfer is enabled and a plurality of standby states on the basis of a load on the data transfer control device and that manages the plurality of transfer resources so as to assume the set operating status; and a load distribution portion that distributes the data to transfer resources that have been set to the transfer-enabled state. The plurality of standby states are states which data transfer is disabled and which mutually differ at a minimum in terms of at least one of power consumption level and transition time to the transfer-enabled state.

Abstract: Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of ?2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and ? defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.

Abstract: Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of ?2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and ? defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.

Abstract: It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.

Abstract: Provide milk powders for confectionery and bakery products that, when added during the production of confectionery and bakery products, can increase the volume of breads, pancakes, cakes, pies, etc., and further add a desirable texture and feel in the mouth to breads, pancakes and cakes. Obtain milk powders for confectionery and bakery products containing 4 to 10 weight-percent of non-protein nitrogen (based on the weight of converted protein) and 1 to 20 weight-percent of ash in a manner keeping the ratio of non-protein nitrogen to total nitrogen to 0.5 or less, by intermixing, as appropriate, dairy ingredients containing non-protein nitrogen with other dairy ingredients such as whole milk powders, skim milk powders, buttermilk powders, whey powders, milk minerals, whey protein concentrates and milk protein concentrates.

Abstract: A highly safe bone resorption suppressing agents, which can be used as medicines or admixed to food products or feeds, is produced. Milk-derived basic cystatins and/or milk-derived basic cystatin decomposition products prepared from milk are made into bone resorption suppressing agents, or admixed to drinks, food products and feeds.

Abstract: In an information processing apparatus, a transmission distortion of a signal transmitted between a module and a controller is reduced. A plurality of modules and a controller controlling the modules are mounted on a circuit board. A bus line connects the controller to the modules, the bus line including a main line and a plurality of branch lines each of which is branched from the main line and is connected to a respective one of the modules. Impedance matching elements are provided to the main line of the bus line so as to match a characteristic impedance between the controller and each of the modules. Each of the impedance matching elements is located behind a branch point of one of the branch lines connected to the respective one of the modules with respect to the controller.