Abstract: Methods for performing endovascular procedures are described herein. The methods may comprise advancing an expandable member of a blood flow control device to a target location in a blood vessel of a patient, and rotating a circular gear positioned at least partially within a housing of a controller via the controller communicably coupled to the blood flow control device. Rotating the circular gear may translate a linear gear of a syringe pump fluidly coupled to the expandable member thereby adjusting a volume of the expandable member. Various blood flow control devices, control systems, and fluid delivery systems are also described herein. The fluid delivery systems may include a pump configured for manual or automated delivery of fluids, or configured to switch between automated and manual modes of delivery. The pump may be a syringe pump that utilizes a rack and pinion system, a motor, and a sensor to track the position and/or movement of a component of the syringe pump during fluid transfer.

Abstract: A hydraulic fracturing plan executable by a hydraulic fracturing system to hydraulically fracture a plurality of oil and gas wells.

Abstract: Aspects of the disclosure provide for methods, systems, and apparatuses, including computer storage media, for adaptively routing web traffic. A system can receive from a user computing device accessing a web resource, a content request, including data characterizing user interaction by the user computing device with the web resource before or after receiving the first content request. The system can identify a policy from a plurality of policies to execute in accordance with one or more objectives, wherein the plurality of policies are generated using data from a plurality of content requests and data characterizing user interaction with the web resource after serving a respective response to each of the plurality of content requests. The system can perform, in response to the content request, one or more actions of the ranked list of actions of the identified policy.

Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user.

Abstract: A closed-loop hydraulic drilling system generates choke characteristic curves or data that more accurately reflects the relationship between the commanded choke valve position and the resulting pressure drop across the choke valve for a given flow rate and fluid density. The choke characteristic curves may be generated through a calibration procedure and then used during normal operations to more accurately monitor return flow and manage wellbore pressure. The specific gravity of an injected calibration fluid and pressure drop across the choke valve may be determined and correlated to the current choke valve position to reflect the choke characteristic curve in situ, thereby providing for more precise control of wellbore pressure and enabling condition monitoring of the choke valve. In addition, an improved closed-loop hydraulic drilling system does not require a flow meter, enabling the adoption of MPD systems in low-specification and economically constrained applications.

Abstract: A hydraulic fracturing plan executable by a hydraulic fracturing system to hydraulically fracture a plurality of oil and gas wells.

Abstract: A method of monitoring a well state with intermittent well state sampling includes determining a measured volume differential by measuring flow out of a wellbore, measuring flow into the wellbore, and calculating a difference between the measured flow out and the measured flow in. The method includes determining an expected volume differential by calculating a fluid volume of the wellbore system, determining a wellbore pressure difference, determining a well system bulk modulus, and multiplying the fluid volume of the wellbore by the wellbore pressure difference and dividing a result by the well system bulk modulus. If the expected volume differential is not substantially equal to the measured volume differential, reporting to the user that the well state is experiencing a significant change requiring user intervention.

Abstract: A harsh environment integrated MPD riser joint includes a dynamic annular sealing system, a static annular sealing system disposed directly below the dynamic annular sealing system, and a flow spool, or equivalent thereof, disposed directly below the static annular sealing system. The dynamic annular sealing system may be a conventional ACD-type, RCD-type, or other conventional annular sealing system. The static annular sealing system may include one or more annular packer systems and one or more connection sealing elements that engage drill pipe during connection or non-rotation operations only. The dynamic annular sealing system may maintain annular pressure during drilling operations while the static annular sealing system is disengaged. The static annular sealing system may maintain annular pressure during connection operations while the dynamic annular sealing system is disengaged.

Abstract: A closed-loop hydraulic drilling system generates choke characteristic curves or data that more accurately reflects the relationship between the commanded choke valve position and the resulting pressure drop across the choke valve for a given flow rate and fluid density. The choke characteristic curves may be generated through a calibration procedure and then used during normal operations to more accurately monitor return flow and manage wellbore pressure. The specific gravity of an injected calibration fluid and pressure drop across the choke valve may be determined and correlated to the current choke valve position to reflect the choke characteristic curve in situ, thereby providing for more precise control of wellbore pressure and enabling condition monitoring of the choke valve. In addition, an improved closed-loop hydraulic drilling system does not require a flow meter, enabling the adoption of MPD systems in low-specification and economically constrained applications.

Abstract: Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.

Abstract: An integrated managed pressure drilling (“MPD”) riser joint includes an annular sealing system that allows for the installation, engagement, service, maintenance, disengagement, removal, or replacement of one or more sealing elements while maintaining a pressure tight seal on the annulus without a drill string isolation tool, or equivalent thereof. The integrated MPD riser joint is limited to the annular sealing system and a flow spool, or equivalent thereof, disposed directly below the annular sealing system, without any intervening pressure containment devices or systems. Advantageously, the integrated MPD riser joint does not require a drill string isolation tool, or equivalent thereof, and may be substantially shorter in length and weigh substantially less than a conventional integrated MPD riser joint. The reduction in size and weight enables adoption of MPD technology in applications where conventional integrated MPD riser joints are not economically feasible or are otherwise precluded from use.

Abstract: A method of seal condition monitoring may determine the state of the annular seal, the state of one or more sealing elements, take actions to maintain the annular seal as one or more sealing elements transition from new to worn, and provide advance notice of the impending failure of one or more sealing elements so as to avoid a catastrophic annular seal failure while the marine riser is pressurized. Advantageously, operations may be conducted proactively rather than reactively, and one or more sealing elements may be replaced well in advance of failure, but potentially later than a conventional maintenance schedule would dictate. The one or more failing sealing elements may be proactively replaced without depressurizing the marine riser, prior to seal failure or replacement may be planned well in advance and coordinated with other rig operations to improve efficiency and maintain the safety of the drilling rig and personnel.

Abstract: A method of seal condition monitoring may determine the state of the annular seal, the state of one or more sealing elements, take actions to maintain the annular seal as one or more sealing elements transition from new to worn, and provide advance notice of the impending failure of one or more sealing elements so as to avoid a catastrophic annular seal failure while the marine riser is pressurized. Advantageously, operations may be conducted proactively rather than reactively, and one or more sealing elements may be replaced well in advance of failure, but potentially later than a conventional maintenance schedule would dictate. The one or more failing sealing elements may be proactively replaced without depressurizing the marine riser, prior to seal failure or replacement may be planned well in advance and coordinated with other rig operations to improve efficiency and maintain the safety of the drilling rig and personnel.

Abstract: A closed-loop hydraulic drilling system generates choke characteristic curves or data that more accurately reflects the relationship between the commanded choke valve position and the resulting pressure drop across the choke valve for a given flow rate and fluid density. The choke characteristic curves may be generated through a calibration procedure and then used during normal operations to more accurately monitor return flow and manage wellbore pressure. The specific gravity of an injected calibration fluid and pressure drop across the choke valve may be determined and correlated to the current choke valve position to reflect the choke characteristic curve in situ, thereby providing for more precise control of wellbore pressure and enabling condition monitoring of the choke valve. In addition, an improved closed-loop hydraulic drilling system does not require a flow meter, enabling the adoption of MPD systems in low-specification and economically constrained applications.

Abstract: A closed-loop hydraulic drilling system generates choke characteristic curves or data that more accurately reflects the relationship between the commanded choke valve position and the resulting pressure drop across the choke valve for a given flow rate and fluid density. The choke characteristic curves may be generated through a calibration procedure and then used during normal operations to more accurately monitor return flow and manage wellbore pressure. The specific gravity of an injected calibration fluid and pressure drop across the choke valve may be determined and correlated to the current choke valve position to reflect the choke characteristic curve in situ, thereby providing for more precise control of wellbore pressure and enabling condition monitoring of the choke valve. In addition, an improved closed-loop hydraulic drilling system does not require a flow meter, enabling the adoption of MPD systems in low-specification and economically constrained applications.

Abstract: A hydraulic fracturing plan executable by a hydraulic fracturing system to hydraulically fracture a plurality of oil and gas wells.

Abstract: Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system.

Abstract: Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system.

Abstract: Disclosed are systems and methods for reducing blood pressure variability in a patient. The system includes an endovascular catheter having an expandable element and one or more blood pressure sensors, and a computer/processing unit configured to receive blood pressure measurements and determine a blood pressure variability metric. Upon determining that the blood pressure variability metric exceeds a given blood pressure variability threshold or falls outside a predefined range, the computer/processing unit directs a catheter controller to adjust the size of the expandable element of the catheter, thereby modulating blood pressure and reducing blood pressure variability.

Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.