Abstract: A harsh environment integrated MPD riser joint includes a dynamic annular sealing system, a static annular sealing system disposed directly below the dynamic annular sealing system, and a flow spool, or equivalent thereof, disposed directly below the static annular sealing system. The dynamic annular sealing system may be a conventional ACD-type, RCD-type, or other conventional annular sealing system. The static annular sealing system may include one or more annular packer systems and one or more connection sealing elements that engage drill pipe during connection or non-rotation operations only. The dynamic annular sealing system may maintain annular pressure during drilling operations while the static annular sealing system is disengaged. The static annular sealing system may maintain annular pressure during connection operations while the dynamic annular sealing system is disengaged.

Abstract: An integrated managed pressure drilling (“MPD”) riser joint includes an annular sealing system that allows for the installation, engagement, service, maintenance, disengagement, removal, or replacement of one or more sealing elements while maintaining a pressure tight seal on the annulus without a drill string isolation tool, or equivalent thereof. The integrated MPD riser joint is limited to the annular sealing system and a flow spool, or equivalent thereof, disposed directly below the annular sealing system, without any intervening pressure containment devices or systems. Advantageously, the integrated MPD riser joint does not require a drill string isolation tool, or equivalent thereof, and may be substantially shorter in length and weigh substantially less than a conventional integrated MPD riser joint. The reduction in size and weight enables adoption of MPD technology in applications where conventional integrated MPD riser joints are not economically feasible or are otherwise precluded from use.

Abstract: A seal assembly for use in a pressure containment device for containing a fluid pressure in an annular space around a drill string whilst allowing the drill string to rotate in the pressure containment device. The seal assembly includes a seal with an inner surface and a tubular body, and a wear sensor embedded in the tubular body of the seal. The wear sensor emits an alert signal when the inner surface of the seal has been worn away by a first preset amount. The alert signal includes a pressure signal and/or a chemical signal.

Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.

Abstract: An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.

Abstract: A method used in fabrication of integrated circuitry comprises forming metal material outwardly of a substrate. At least a majority (i.e., up to and including 100%) of the metal material contains ruthenium in at least one of elemental-form, metal compound-form, or alloy-form. A masking material is formed outwardly of the ruthenium-containing metal material. The masking material comprises at least one of nine specifically enumerated materials or category of materials. The masking material is used as a mask while etching through an exposed portion of the ruthenium-containing metal material to form a feature of integrated circuitry that comprises the ruthenium-containing metal material.

Abstract: The invention is an improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The invention is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.

Abstract: A method used in fabrication of integrated circuitry comprises forming metal material outwardly of a substrate. At least a majority (i.e., up to and including 100%) of the metal material contains ruthenium in at least one of elemental-form, metal compound-form, or alloy-form. A masking material is formed outwardly of the ruthenium-containing metal material. The masking material comprises at least one of nine specifically enumerated materials or category of materials. The masking material is used as a mask while etching through an exposed portion of the ruthenium-containing metal material to form a feature of integrated circuitry that comprises the ruthenium-containing metal material.

Abstract: A method of seal condition monitoring may determine the state of the annular seal, the state of one or more sealing elements, take actions to maintain the annular seal as one or more sealing elements transition from new to worn, and provide advance notice of the impending failure of one or more sealing elements so as to avoid a catastrophic annular seal failure while the marine riser is pressurized. Advantageously, operations may be conducted proactively rather than reactively, and one or more sealing elements may be replaced well in advance of failure, but potentially later than a conventional maintenance schedule would dictate. The one or more failing sealing elements may be proactively replaced without depressurizing the marine riser, prior to seal failure or replacement may be planned well in advance and coordinated with other rig operations to improve efficiency and maintain the safety of the drilling rig and personnel.

Abstract: A method of seal condition monitoring may determine the state of the annular seal, the state of one or more sealing elements, take actions to maintain the annular seal as one or more sealing elements transition from new to worn, and provide advance notice of the impending failure of one or more sealing elements so as to avoid a catastrophic annular seal failure while the marine riser is pressurized. Advantageously, operations may be conducted proactively rather than reactively, and one or more sealing elements may be replaced well in advance of failure, but potentially later than a conventional maintenance schedule would dictate. The one or more failing sealing elements may be proactively replaced without depressurizing the marine riser, prior to seal failure or replacement may be planned well in advance and coordinated with other rig operations to improve efficiency and maintain the safety of the drilling rig and personnel.

Abstract: A dual gradient drilling system includes a subsea blowout preventer disposed above a wellhead, the subsea blowout preventer having a central lumen configured to provide access to a wellbore, a lower section of a marine riser fluidly connected to the subsea blowout preventer, a closed-hydraulic positive displacement subsea pump system fluidly connected to the lower section of the marine riser and disposed at a predetermined depth, an annular sealing system disposed above the closed-hydraulic positive displacement subsea pump system, and an independent mud return line fluidly connecting one or more pump heads of the closed-hydraulic positive displacement subsea pump system to a choke manifold disposed on a floating platform of a rig.

Abstract: A dual gradient drilling system includes a subsea blowout preventer disposed above a wellhead, the subsea blowout preventer having a central lumen configured to provide access to a wellbore, a lower section of a marine riser fluidly connected to the subsea blowout preventer, a closed-hydraulic positive displacement subsea pump system fluidly connected to the lower section of the marine riser and disposed at a predetermined depth, an annular sealing system disposed above the closed-hydraulic positive displacement subsea pump system, and an independent mud return line fluidly connecting one or more pump heads of the closed-hydraulic positive displacement subsea pump system to a choke manifold disposed on a floating platform of a rig.

Abstract: A dual gradient drilling system includes a subsea blowout preventer disposed above a wellhead, the subsea blowout preventer having a central lumen configured to provide access to a wellbore, a lower section of a marine riser fluidly connected to the subsea blowout preventer, a closed-hydraulic positive displacement subsea pump system fluidly connected to the lower section of the marine riser and disposed at a predetermined depth, an annular sealing system disposed above the closed-hydraulic positive displacement subsea pump system, and an independent mud return line fluidly connecting one or more pump heads of the closed-hydraulic positive displacement subsea pump system to a choke manifold disposed on a floating platform of a rig.

Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user.

Abstract: Systems and methods for partial aortic occlusion are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient, and a catheter controller unit that causes the device to expand and contract to restrict blood flow through the aorta. The system also may include sensors for measuring blood pressure distal and proximal to the expandable device.

Abstract: Systems and methods for Endovascular Perfusion Augmentation for Critical Care (EPACC) are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient. The system may also include a catheter controller unit that causes the expandable aortic blood flow regulation device to expand and contract to restrict blood flow through the aorta.

Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.

Abstract: A seal assembly for use in a pressure containment device for containing a fluid pressure in an annular space around a drill string whilst allowing the drill string to rotate in the pressure containment device. The seal assembly includes a seal with an inner surface and a tubular body, and a wear sensor embedded in the tubular body of the seal. The wear sensor emits an alert signal when the inner surface of the seal has been worn away by a first preset amount. The alert signal includes a pressure signal and/or a chemical signal.