Patents by Inventor Avi Ashkenazi

Avi Ashkenazi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods Relating to Stop-1
    Publication number: 20080050377
    Abstract: The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
    Type: Application
    Filed: April 16, 2004
    Publication date: February 28, 2008
    Applicant: GENENTECH, INC.
    Inventors: Heidi Ackerly, Avi Ashkenazi, David Eberhard, Gretchen Frantz, Dorothy French, Germaine G. Fuh, Jo-Anne S. Hongo, Chingwei V. Lee, Scot A. Marsters, Helga A. Raab, Evgeny Varfolomeev, Beni B. Wolf, Robert Maurice Pitti, Liliana Soroceanu
  • Methods of using death receptor ligands and CD20 antibodies
    Publication number: 20080044421
    Abstract: Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and CD20 antibodies to treat conditions such as cancer and immune related diseases are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with CD20 antibodies.
    Type: Application
    Filed: October 3, 2006
    Publication date: February 21, 2008
    Applicant: Genentech, Inc.
    Inventor: Avi Ashkenazi
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20070254302
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: June 21, 2007
    Publication date: November 1, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Paul Polakis, Victoria Smith, William Wood, Thomas Wu, Zemin Zhang
  • Methods of using death receptor ligands and CD20 antibodies
    Publication number: 20070231324
    Abstract: Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and CD20 antibodies to treat conditions such as cancer and immune related diseases are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with CD20 antibodies.
    Type: Application
    Filed: October 3, 2006
    Publication date: October 4, 2007
    Applicant: Genentech, Inc.
    Inventor: Avi Ashkenazi
  • Compositions and Methods for the Diagnosis and Treatment of Tumor
    Publication number: 20070212735
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: September 25, 2006
    Publication date: September 13, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Belinda Caims, Patrick Dowd, Gretchen Frantz, Dorothy French, Lino Gonzalez, Paul Polakis, Victoria Smith, Beni Wolf, Thomas Wu, Zemin Zhang
  • Prevention and treatment of complement-associated disorders
    Publication number: 20070190054
    Abstract: The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the prevention and treatment of complement-associated disorders, including complement-associated eye conditions, such as age-related macular degeneration (AMD) and choroidal neovascularization (CNV).
    Type: Application
    Filed: October 12, 2005
    Publication date: August 16, 2007
    Inventors: Avi Ashkenazi, Karim Helmy, Sherman Fong, Audrey Goddard, Austin Gurney, Kenneth Katschke, Menno Lookeren, William Wood
  • Use of A33 antigens and JAM-IT
    Publication number: 20070190049
    Abstract: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
    Type: Application
    Filed: March 15, 2007
    Publication date: August 16, 2007
    Inventors: Avi Ashkenazi, Sherman Fong, Audrey Goddard, Austin Gurney, Mary Napier, Daniel Tumas, Menno Lookeren, William Wood
  • Compositions and Methods for the Diagnosis and Treatment of Tumor
    Publication number: 20070178486
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: September 27, 2006
    Publication date: August 2, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Dan Eaton, Audrey Goddard, Austin Gurney, William Wood, Thomas Wu
  • Methods for making Apo-2 ligand using divalent metal ions
    Publication number: 20070161564
    Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
    Type: Application
    Filed: November 22, 2006
    Publication date: July 12, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Sarah Hymowitz, Robert Kelley, Iphigenia Koumenis, Woon-Lam Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
  • Assays and methods using biomarkers
    Publication number: 20070141023
    Abstract: Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.
    Type: Application
    Filed: October 3, 2006
    Publication date: June 21, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Klaus Wagner
  • Non-human transgenic animal models for hepatocellular carcinoma
    Publication number: 20070143871
    Abstract: The invention relates to the field of non-human, transgenic animal models for hepatocellular carcinoma.
    Type: Application
    Filed: November 6, 2006
    Publication date: June 21, 2007
    Applicant: Genentech, Inc.
    Inventors: Dorothy French, Avi Ashkenazi, Jean-Philippe Stephan, Luc Desnoyers
  • Assays and methods using biomarkers
    Publication number: 20070134251
    Abstract: Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.
    Type: Application
    Filed: October 3, 2006
    Publication date: June 14, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Klaus Wagner
  • Treatment of Inflammatory Bowel Disease with IFN-Gamma Inhibitors
    Publication number: 20070104712
    Abstract: The invention concerns a method for the prevention or treatment of inflammatory bowel disease by administering an interferon-? inhibitor. The invention further concerns pharmaceutical compositions and bispecific molecules useful in such method.
    Type: Application
    Filed: September 29, 2006
    Publication date: May 10, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Rebecca Ward
  • Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
    Patent number: 7211400
    Abstract: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: May 1, 2007
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, Sherman Fong, Audrey Goddard, Austin L. Gurney, Mary A. Napier, Daniel Tumas, William I. Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7208308
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: April 24, 2007
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Giang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
    Publication number: 20070087007
    Abstract: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
    Type: Application
    Filed: November 30, 2006
    Publication date: April 19, 2007
    Inventors: Avi Ashkenazi, Sherman Fong, Audrey Goddard, Austin Gurney, Mary Napier, Daniel Tumas, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20070077623
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 7, 2006
    Publication date: April 5, 2007
    Applicant: GENENTECH, INC.
    Inventors: Avi Ashkenazi, David Bolstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Jennie Mather, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
    Patent number: 7198917
    Abstract: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: April 3, 2007
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, Sherman Fong, Audrey Goddard, Austin L. Gurney, Mary A. Napier, Daniel Tumas, William I. Wood
  • RTD receptor
    Publication number: 20070074296
    Abstract: Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also provided.
    Type: Application
    Filed: August 17, 2006
    Publication date: March 29, 2007
    Inventors: Avi Ashkenazi, Austin Gurney
  • DNA19355 polypeptide, a tumor necrosis factor homolog
    Publication number: 20070072263
    Abstract: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
    Type: Application
    Filed: May 6, 2005
    Publication date: March 29, 2007
    Inventors: Avi Ashkenazi, Kevin Baker, Paul Godowski, Austin Gurney, Melanie Mark, Scot Marsters, Robert Pitti