Patents by Inventor Avi Ashkenazi

Avi Ashkenazi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Patent number: 7094567
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: August 22, 2006
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Giang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Apo-2 receptor antibodies
    Publication number: 20060177456
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: April 13, 2006
    Publication date: August 10, 2006
    Inventors: Avi Ashkenazi, Anan Chuntharapai, K. Kim
  • Secreted and transmembrane polypeptides nucleic acid encoding
    Patent number: 7074592
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: July 11, 2006
    Assignee: Genetech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jenni P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
    Publication number: 20060141573
    Abstract: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 29, 2006
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Audrey Goddard, Austin Gurney, Scot Marsters, Robert Pitti, William Wood
  • Apo-2 receptor
    Publication number: 20060115484
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: December 9, 2005
    Publication date: June 1, 2006
    Inventors: Camellia Adams, Avi Ashkenazi, Anan Chuntharapai, Kyung Kim
  • Apo-2 receptor
    Publication number: 20060084147
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: December 9, 2005
    Publication date: April 20, 2006
    Inventors: Camellia Adams, Avi Ashkenazi, Anan Chuntharapai, Kyung Kim
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060078964
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: August 9, 2002
    Publication date: April 13, 2006
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Uses of agonists and antagonists to modulate activity of TNF-related molecules
    Publication number: 20060073146
    Abstract: Methods of using one or more agonists or antagonists to modulate activity of the members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA are provided. The methods include in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with TALL-1, APRIL, TACI, or BCMA, using one or more agonist or antagonist molecules. The methods of treatment disclosed by the invention include methods of treating immune related diseases and cancer.
    Type: Application
    Filed: February 28, 2005
    Publication date: April 6, 2006
    Inventors: Avi Ashkenazi, Kelly Dodge, Iqbal Grewal, Kyung Kim, Scot Marsters, Robert Pitti, Minhong Yan
  • Apo-2 receptor
    Publication number: 20060073570
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: December 9, 2005
    Publication date: April 6, 2006
    Inventors: Camellia Adams, Avi Ashkenazi, Anan Chuntharapai, Kyung Kim
  • Compositions and methods for treatment of non-hodgkin's lymphoma
    Publication number: 20060057148
    Abstract: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.
    Type: Application
    Filed: June 30, 2005
    Publication date: March 16, 2006
    Inventors: Avi Ashkenazi, Dylan Daniel, Theresa Shek
  • Apo-3 polypeptide
    Publication number: 20060041106
    Abstract: Novel polypeptides, designated Apo-3, which are capable of stimulating or inducing apoptosis are provided. Compositions including Apo-3 chimeras, nucleic acid encoding Apo-3, and antibodies to Apo-3 are also provided.
    Type: Application
    Filed: July 6, 2005
    Publication date: February 23, 2006
    Inventor: Avi Ashkenazi
  • Apo-2 receptor
    Publication number: 20060035334
    Abstract: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided.
    Type: Application
    Filed: October 7, 2005
    Publication date: February 16, 2006
    Inventors: Camellia Adams, Avi Ashkenazi, Anan Chuntharapai, Kyung Kim
  • Apo-2DcR
    Publication number: 20060020114
    Abstract: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
    Type: Application
    Filed: April 28, 2005
    Publication date: January 26, 2006
    Inventors: Avi Ashkenazi, Kevin Baker, Austin Gurney, William Wood
  • Treatment of complement-associated disorders
    Publication number: 20060002944
    Abstract: The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.
    Type: Application
    Filed: June 22, 2005
    Publication date: January 5, 2006
    Inventors: Avi Ashkenazi, Karim Helmy, Sherman Fong, Audrey Goddard, Austin Gurney, Kenneth Katschke, Menno Lookeren, William Wood
  • Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
    Publication number: 20050282230
    Abstract: A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.
    Type: Application
    Filed: April 13, 2005
    Publication date: December 22, 2005
    Inventors: Avi Ashkenazi, Anan Chuntharapai, K. Kim
  • Nucleic acid encoding PRO211 polypeptides
    Patent number: 6974689
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: December 13, 2005
    Assignee: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Apo-2 ligand-anti-Her-2 antibody synergism
    Publication number: 20050244417
    Abstract: Methods of using synergistically effective amounts of Apo-2 ligand and anti-Her-2 antibodies to enhance cell death via apoptosis are provided.
    Type: Application
    Filed: June 15, 2005
    Publication date: November 3, 2005
    Inventors: Avi Ashkenazi, Gail Phillips
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050227342
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 19, 2001
    Publication date: October 13, 2005
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20050227328
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: May 13, 2005
    Publication date: October 13, 2005
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Kevin Baker, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Sophia Kuo, Mary Napier, James Pan, Nicholas Paoni, Margaret Roy, David Shelton, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Method for treating tumors using anti-osteopontin antibodies
    Publication number: 20050226868
    Abstract: The present invention is directed to compositions of matter useful for the treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 13, 2004
    Publication date: October 13, 2005
    Inventors: Avi Ashkenazi, Robert Pitti, Thomas Wu, Zemin Zhang