Patents by Inventor Aykut Uren

Aykut Uren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD99 inhibitors and their uses
    Patent number: 11202792
    Abstract: Provided herein are methods of treating a bone or connective tissue cancer in a subject. The methods comprise administering to the subject an effective amount of a CD99 inhibitor, wherein the CD99 inhibitor is a compound having the formula wherein R, each of which may be the same or different, is hydrogen, or a protecting group; wherein Z is selected from the group consisting of F, Cl and Br; wherein X is H or F; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: December 21, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • CD99 Inhibitors and Their Uses
    Publication number: 20190262370
    Abstract: Provided herein are methods of treating cancer in a subject. Also provided are methods of treating autoimmune disorders. The methods comprise administering to the subject an effective amount of a CD99 inhibitor.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 29, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • Novel Ezrin Inhibitors and Methods of Making and Using
    Publication number: 20180148437
    Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growh of a cancer cell.
    Type: Application
    Filed: December 19, 2016
    Publication date: May 31, 2018
    Inventors: Milton L. Brown, Mikell Paige, Jeffrey A. Torestsky, Aykut Uren, George Kosturko, Gullay Bulut
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 9758481
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: September 12, 2017
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong
  • Methods and compositions for treating Ewings sarcoma family of tumors
    Patent number: 9714222
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: July 25, 2017
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20170157089
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Application
    Filed: November 30, 2016
    Publication date: June 8, 2017
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • Ezrin inhibitors and methods of making and using
    Patent number: 9522908
    Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: December 20, 2016
    Assignee: Gerogetown University
    Inventors: Milton L. Brown, Mikell Paige, Jeffrey A. Torestsky, Aykut Uren, George Kosturko, Gullay Bulut
  • Methods and compositions for treating cancer
    Patent number: 9511050
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: December 6, 2016
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20160263086
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 15, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
    Publication number: 20160159741
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 9, 2016
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • Methods and compositions for treating Ewings sarcoma family of tumors
    Patent number: 9290449
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: March 22, 2016
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20150329488
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: April 24, 2015
    Publication date: November 19, 2015
    Inventors: Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 9045415
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: June 2, 2015
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
    Publication number: 20150051260
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Application
    Filed: April 11, 2013
    Publication date: February 19, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • Methods of use of fragments of secreted frizzled related protein, sFRP
    Patent number: 8735355
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: May 27, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING
    Publication number: 20140135325
    Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.
    Type: Application
    Filed: October 7, 2013
    Publication date: May 15, 2014
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Mikell Paige, Jeffrey A. Torestsky, Aykut Uren, George Kosturko, Gullay Bulut
  • sFRP and peptide motifs that interact with sFRP and methods of their use
    Patent number: 8334260
    Abstract: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: December 18, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, St. Vincent's Institute of Medical Research
    Inventors: Jeffrey S. Rubin, Aykut Üren, Brian K. Kay, Bernard Weisblum, Matthew Todd Gillespie, Nicole Joy Horwood
  • SECRETED FRIZZLED RELATED PROTEIN, SFRP, FRAGMENTS AND METHODS OF USE THEREOF
    Publication number: 20120202749
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Application
    Filed: March 21, 2012
    Publication date: August 9, 2012
    Inventors: Jeffrey S. Rubin, Susan Cumberledge, Frieda Reichsman, Aykut Uren
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 8232310
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • Fragments of secreted frizzled related protein
    Patent number: 8158603
    Abstract: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: April 17, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Massachusetts
    Inventors: Jeffrey S. Rubin, Aykut Üren, Susan Cumberledge, Frieda Reichsman