Abstract: Systems and methods for assisting the placement of a catheter within the body of a patient through the use of an ultrasound imaging system are disclosed. In particular, the systems and methods described herein enable a clinician to determine, prior to insertion of the medical device, how much of the device will be disposed within the vessel, thus enabling the clinician to choose a catheter with suitable length. In one embodiment, an ultrasound imaging system for assisting with placement of the medical device comprises a console, a probe for producing an image of a target location, and a processor. The processor provides to a user proximity information relating to the anticipated proximity of the medical device to the target location prior to insertion of the medical device. A display is included for depicting the image, target location depth, and the proximity information of the medical device to the target location.

Abstract: Catalytic metal loss when using a hydroformylation catalyst comprising an organophosphite ligand is ameliorated by adding CO to a strip gas vaporizer.

Abstract: A cryogenic LNG fuel system is provided that includes a tank for storing LNG and a LNG fill system including a LNG inlet passage for directing a flow of LNG into the tank. A cryogenic pump is in fluid communication with the tank and includes a pumping element at least partially immersed in the LNG for directing the LNG out of the tank and a seal. A lubricant system is provided that includes a lubricant reservoir and a lubricant inlet passage in communication with the lubricant reservoir and the LNG inlet passage. The lubricant system is adapted to introduce the lubricant into the flow of LNG in the LNG inlet passage such that at least a portion of the lubricant is entrained in the LNG in the LNG inlet passage and carried into the tank.

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Abstract: A valve assembly for a fuel pump is provided. The valve assembly may include an inlet valve limited to a first range of travel extending between a fully closed position and a fully opened position of the inlet valve, a valve pin coupled to the inlet valve, an armature pin selectively engaging the valve pin, and an armature coupled to the armature pin and limited to a second range of travel extending between an engaged position and a disengaged position that is less than the first range of travel.

Abstract: A system for identifying an attribute of an implanted medical device, such as an access port. In one embodiment, the identification system comprises a marker included with the implanted medical device, the marker relating to an attribute of the implanted medical device. An external detection device is also included, comprising a signal source that emits an incident electromagnetic signal for impingement on the marker of the implanted medical device, a detector that detects a return signal from the marker resulting from impingement of the incident electromagnetic signal, and a user interface for conveying information relating to the attribute based on detection of the return signal. In the case of an implantable access port, for instance, the described system enables information, such as the ability of the port to withstand power injection of fluids therethrough, to be ascertained even after the port has been subcutaneously implanted within the patient.

Abstract: Systems and methods for assisting the placement of a catheter within the body of a patient through the use of an ultrasound imaging system are disclosed. In particular, the systems and methods described herein enable a clinician to determine, prior to insertion of the medical device, how much of the device will be disposed within the vessel, thus enabling the clinician to choose a catheter with suitable length. In one embodiment, an ultrasound imaging system for assisting with placement of the medical device comprises a console, a probe for producing an image of a target location, and a processor. The processor provides to a user proximity information relating to the anticipated proximity of the medical device to the target location prior to insertion of the medical device. A display is included for depicting the image, target location depth, and the proximity information of the medical device to the target location.

Abstract: A bi-directional valve assembly, including valves for use in closed-ended catheters or other elongate tubular devices, is disclosed. In one embodiment, a catheter assembly for insertion into a body of a patient is disclosed and comprises an elongate catheter tube including an outer wall that at least partially defines at least one lumen that extends between a proximal end and a closed distal end thereof. The catheter tube includes a valve assembly that in turn includes a linear slit valve defined through the outer wall of a distal segment of the catheter tube, and a deformation region. The deformation region includes a compliant segment disposed in the outer wall of the catheter tube and a thinned portion of the outer wall. The compliant segment and thinned portion of the deformation region cooperate to preferentially deform the outer wall and open the slit valve during aspiration through the catheter tube.

Abstract: A system for identifying an attribute of an implanted medical device, such as an access port is disclosed. In one embodiment, the identification system comprises a marker included with the implanted medical device, wherein the marker relates to an attribute of the implanted medical device. An external detection device is also included, comprising a signal source that emits an incident electromagnetic signal for impingement on the marker of the implanted medical device, a detector that detects a return signal from the marker resulting from impingement of the incident electromagnetic signal, and a user interface for conveying information relating to the attribute based on detection of the return signal. In the case of an implantable access port, for instance, the described system enables information, such as the ability of the port to withstand power injection of fluids therethrough, to be ascertained even after the port has been subcutaneously implanted within the patient.

Abstract: Methods and apparatus to determine a plunge depth position of material conditioning machines are disclosed. An example method incrementally adjusting a first plunge depth position of a first adjustable work roll and a first fixed work roll between an initial first roll plunge depth position and a final first roll plunge depth position. The method includes incrementally adjusting a second plunge depth position of a second adjustable work roll and a second fixed work roll between an initial second roll plunge depth position and a final second roll plunge depth position. The method includes measuring first pressure values of a first actuator associated with the first adjustable work roll at each incremental first plunge depth position, identifying a first relative minimum pressure value of the measured first pressure values, and determining a first incremental plunge depth position corresponding to the first relative minimum pressure value.

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Abstract: Embodiments of the current invention include methods and compositions for treating breast cancer by administering an effective amount of MJC13 to a subject in need thereof.

Abstract: Catalytic metal loss when using a hydroformylation catalyst comprising an organophosphite ligand is ameliorated by adding CO to a strip gas vaporizer.

Abstract: An apparatus and method display, on a display screen, a graphical user interface (GUI) of a software application having multiple commands, according to at least two different layouts generated by a layout engine. A first layout includes, in a fixed area, a contextual ribbon including groups of controls that each pertain to a function of a particular command, while a second layout includes, in the fixed area, a non-contextual ribbon including groups of controls that each pertain to different commands. The apparatus and method switch between layouts for display in response to receiving a re-layout instruction from a user of the software application. The layout engine operates by processing a command framework, which may be hierarchical, to determine the controls for each layout, and their respective arrangement and sizes within the layout, according to a user experience guideline.

Abstract: A bi-directional valve assembly, including valves for use in closed-ended catheters or other elongate tubular devices, is disclosed. In one embodiment, a catheter assembly for insertion into a body of a patient is disclosed and comprises an elongate catheter tube including an outer wall that at least partially defines at least one lumen that extends between a proximal end and a closed distal end thereof. The catheter tube includes a valve assembly that in turn includes a linear slit valve defined through the outer wall of a distal segment of the catheter tube, and a deformation region. The deformation region includes a compliant segment disposed in the outer wall of the catheter tube and a thinned portion of the outer wall. The compliant segment and thinned portion of the deformation region cooperate to preferentially deform the outer wall and open the slit valve during aspiration through the catheter tube.

Abstract: Methods and apparatus to determine a plunge depth position of material conditioning machines are disclosed. An example method for setting a plunge depth of a leveler includes incrementally adjusting, via an actuator, a first work roll relative to a second work roll between a plurality of incremental plunge depth positions; measuring a pressure value in the actuator at the respective incremental plunge depth positions; associating the measured pressure values with the corresponding incremental plunge depth positions; detecting a smallest one of the measured pressure values; and identifying a first one of the incremental plunge depth positions corresponding to the smallest one of the measured pressure values.

Abstract: An air data probe includes a probe body. The air data probe also includes a housing surrounding the probe body, wherein a cavity is defined between the probe body and the housing. The air data probe also includes a heater element disposed within the cavity between the probe body and the housing. The air data probe also includes a low melting point metal disposed within the cavity between the probe body and the housing, wherein engaging the heater element causes at least a portion of the low melting point metal to transition from a solid state to a liquid state.

Abstract: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.

Abstract: A catheter placement system for positioning a catheter in a vasculature of a patient using at least two different modalities. The catheter placement system includes a console with a display, a stylet removably positionable within a lumen of the catheter, a tip location sensor, and an external electrode. The stylet may include an electrocardiogram (ECG) sensor assembly for detecting ECG signals of a node of a heart of the patient, and a first connector in communication with the ECG sensor assembly. The tip location sensor may be configured to detect the stylet when the catheter is disposed within the vasculature of the patient, and to communicate information of the stylet to the console. The console may be configured to receive at least one aspect of the ECG signal detected by the ECG sensor assembly indicative of proximity of the ECG sensor assembly to the node.

Abstract: An integrated catheter placement system for accurately placing a catheter within a patient's vasculature is disclosed. In one embodiment, the integrated system comprises a system console, a tip location sensor for temporary placement on the patient's chest, and an ultrasound probe. The tip location sensor senses a magnetic field of a stylet disposed in a lumen of the catheter when the catheter is disposed in the vasculature. The ultrasound probe ultrasonically images a portion of the vasculature prior to introduction of the catheter. ECG signal-based catheter tip guidance is included in the integrated system to enable guidance of the catheter tip to a desired position with respect to a node of the patient's heart. Various methods for establishing a conductive pathway between a sterile field of the patient and a non-sterile field are also disclosed.