Abstract: A multi-reactor hydroformylation process wherein a common product-catalyst separation zone is employed.

Abstract: A multi-reaction train hydroformylation process wherein a common product-catalyst separation zone is employed.

Abstract: An integrated catheter placement system for accurately placing a catheter within a patient's vasculature is disclosed. In one embodiment, the integrated system comprises a system console, a tip location sensor for temporary placement on the patient's chest, and an ultrasound probe. The tip location sensor senses a magnetic field of a stylet disposed in a lumen of the catheter when the catheter is disposed in the vasculature. The ultrasound probe ultrasonically images a portion of the vasculature prior to intravascular introduction of the catheter. The ultrasound probe includes user input controls for controlling use of the ultrasound probe in an ultrasound mode and use of the tip location sensor in a tip location mode. In another embodiment, ECG signal-based catheter tip guidance is included in the integrated system to enable guidance of the catheter tip to a desired position with respect to a node of the patient's heart.

Abstract: A process of controlling hydroformylation reaction fluid temperature involves controlling the flow rate of reaction fluid through an external heat exchanger.

Abstract: An integrated catheter placement system for accurately placing a catheter within a patient's vasculature is disclosed. In one embodiment, the integrated system comprises a system console, a tip location sensor for temporary placement on the patient's chest, and an ultrasound probe. The tip location sensor senses a magnetic field of a stylet disposed in a lumen of the catheter when the catheter is disposed in the vasculature. The ultrasound probe ultrasonically images a portion of the vasculature prior to introduction of the catheter. ECG signal-based catheter tip guidance is included in the integrated system to enable guidance of the catheter tip to a desired position with respect to a node of the patient's heart. Various means for establishing a conductive pathway between a sterile field of the patient and a non-sterile field to enable passage of ECG signals from the catheter to the tip location sensor are also disclosed.

Abstract: An integrated catheter placement system for accurately placing a catheter within a patient's vasculature is disclosed. In one embodiment, the integrated system comprises a system console, a tip location sensor for temporary placement on the patient's chest, and an ultrasound probe. The tip location sensor senses a magnetic field of a stylet disposed in a lumen of the catheter when the catheter is disposed in the vasculature. The ultrasound probe ultrasonically images a portion of the vasculature prior to introduction of the catheter. ECG signal-based catheter tip guidance is included in the integrated system to enable guidance of the catheter tip to a desired position with respect to a node of the patient's heart. Stylets and catheters including various multiple bipolar and monopolar electrode configurations are also disclosed.

Abstract: An air data probe includes a probe body. The air data probe also includes a housing surrounding the probe body, wherein a cavity is defined between the probe body and the housing. The air data probe also includes a heater element disposed within the cavity between the probe body and the housing. The air data probe also includes a low melting point metal disposed within the cavity between the probe body and the housing, wherein engaging the heater element causes at least a portion of the low melting point metal to transition from a solid state to a liquid state.

Abstract: A system for power management of air data probes is provided. The system comprises a power source in an aircraft, and two or more air data probes electrically connected to the power source. Each of the air data probes comprises a body structure coupled to a fuselage of the aircraft, and at least one electrical heater coupled to the body structure and in electrical communication with the power source. A switching mechanism is coupled between the power source and the electrical heater of each of the air data probes. The switching mechanism is controllable such that the electrical heater of each of the air data probes is electrically connectable to the power source in parallel or in series.

Abstract: A pumping mechanism is disclosed. The pumping mechanism may include a barrel formed of a barrel substrate and including a first end surface, a second end surface opposite the first end surface, and a bore between the first and second end surfaces. Each of the first and second end surfaces and the bore is coated with a metal plating. The pumping mechanism may further include a plunger formed of a plunger substrate and configured to be slidably disposed in the bore in barrel, the plunger substrate having a tribological coating.

Abstract: A guidance system for assisting with the insertion of a needle into a patient body is disclosed. The guidance system utilizes ultrasound imaging or other suitable imaging technology. In one embodiment, the guidance system comprises an imaging device including a probe for producing an image of an internal body portion target, such as a vessel. One or more sensors are included with the probe. The sensors sense a detectable characteristic related to the needle, such as a magnetic field of a magnet included with the needle. The system includes a processor that uses data relating to the sensed characteristic to determine a 3-D position of the needle. The system includes a display for depicting the position of the needle. The needle can include a donut-shaped magnet disposed about the needle cannula, or a removable stylet with a magnetic element and a strain gauge for detection of the needle distal tip.

Abstract: An integrated catheter placement system for accurately placing a catheter within a patient's vasculature is disclosed. In one embodiment, the integrated system comprises a system console, a tip location sensor for temporary placement on the patient's chest, and an ultrasound probe. The tip location sensor senses a magnetic field of a stylet disposed in a lumen of the catheter when the catheter is disposed in the vasculature. The ultrasound probe ultrasonically images a portion of the vasculature prior to introduction of the catheter. ECG signal-based catheter tip guidance is included in the integrated system to enable guidance of the catheter tip to a desired position with respect to a node of the patient's heart. Various aspects for visualizing and manipulating display of the ECG signal data acquired via the present system, together with aspects of various ECG sensor configurations, are also disclosed.

Abstract: Methods and apparatus to determine a plunge depth position of material conditioning machines are disclosed. An example method for setting a plunge depth of a leveler includes incrementally adjusting, via an actuator, a first work roll relative to a second work roll between a plurality of incremental plunge depth positions; measuring a pressure value in the actuator at the respective incremental plunge depth positions; associating the measured pressure values with the corresponding incremental plunge depth positions; detecting a smallest one of the measured pressure values; and identifying a first one of the incremental plunge depth positions corresponding to the smallest one of the measured pressure values.

Abstract: The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the invention may be useful for treating immunological and oncological conditions.

Abstract: A method of managing the heat of a chemical reaction process.

Abstract: A guidance system for assisting with the insertion of a needle into a patient body is disclosed. The guidance system utilizes ultrasound imaging or other suitable imaging technology. In one embodiment, the guidance system comprises an imaging device including a probe for producing an image of an internal body portion target, such as a vessel. One or more sensors are included with the probe. The sensors sense a detectable characteristic related to the needle, such as a magnetic field of a magnet included with the needle. The system includes a processor that uses data relating to the sensed characteristic to determine a 3-D position of the needle. The system includes a display for depicting the position of the needle. The needle can include a donut-shaped magnet disposed about the needle cannula, or a removable stylet with a magnetic element and a strain gauge for detection of the needle distal tip.

Abstract: An actuator for a fuel injector provided. The actuator includes an armature that defines a socket. Further, the armature includes an end wall. The actuator also includes a pin that includes a first end and a second end. The first end is slidably received within the socket of the armature, and the second end is in contact with a valve element. The actuator further includes a first stop positioned within the socket between the first end and the end wall. The actuator includes a second stop disposed about a second end of the pin outside of the socket.

Abstract: A multi-reactor hydroformylation process wherein a common product-catalyst separation zone is employed.

Abstract: A multi-reaction train hydroformylation process wherein a common product-catalyst separation zone is employed.

Abstract: Methods and apparatus for monitoring and conditioning strip material are disclosed. A disclosed example method includes coupling a feedback unit to a first material conditioner. The first material conditioner includes a first sensor and a second sensor, where the first and second sensors are located along a width of a first material moving through the first material conditioner, a first adjustable backup bearing and a second adjustable backup bearing. The disclosed example method also includes mapping the first sensor to the first adjustable backup bearing, where the first sensor corresponds to a first longitudinal zone located along a width of the first moving material.

Abstract: A process of controlling hydroformylation reaction fluid temperature involves controlling the flow rate of reaction fluid through an external heat exchanger.