Abstract: This invention generally provides two tactile stimulation modules, or “tappers”. One tapper is held by a person in each of his hands. Alternatively, a tapper is secured to each wrist or to other parts of the body on opposite sides. Each tapper is powered by a rechargeable battery, and contains both a tactile stimulation transducer, such as an electric motor having either a balanced or unbalanced mass on its output shaft, and a transceiver that communicates with a host or master. Each tapper includes at least one control button and a status indicator. Each tapper contains a micro-controller that performs tasks such as communication, motor activation, user monitoring and control, battery monitoring, low-power sleep, and algorithm execution. At least one tapper can contain at least one optional sensor, which measures a physiological function. Measurements can be used to modify performance of the tactile stimulation transducers.

Abstract: A device including a portable frame, comprising a tray and a lid that closes upon the tray, and multiple cavities formed in the tray and configured to receive a container is provided. The cavities are arranged in a pattern according to a dosage dispense sequence for a medication from the container, and to a type of a medication to be dispensed from the container; and a marking along a side of the pattern, the marking indicative of the dosage dispense sequence corresponding to one or more cavities aligned with the marking in the pattern. A method for using the above device to dispense medication to a patient is also provided.

Abstract: A catheter system including a housing and a drive mechanism supported by the housing is provided. The drive mechanism includes an engagement structure configured to engage and to impart movement to a guide wire. The engagement structure defines a path for the guide wire, and the engagement structure is moveable between an engaged position in which the engagement structure engages the guide wire and a disengaged position in which the engagement structure does not engage the guide wire. The catheter system includes a biasing element configured to bias the engagement structure toward the engaged position, and the biasing element is aligned generally parallel to the path defined by the engagement structure.

Abstract: This disclosure relates to systems and methods of towing, hitching, and connecting devices. In particular, this disclosure relates to tow devices, hitches, and connections for towing item containers behind vehicles, both autonomous and manually guided.

Abstract: This disclosure relates to systems and methods of towing, hitching, and connecting devices. In particular, this disclosure relates to tow devices, hitches, and connections for towing item containers behind vehicles, both autonomous and manually guided.

Abstract: A device including a portable frame, comprising a tray and a lid that closes upon the tray, and multiple cavities formed in the tray and configured to receive a container is provided. The cavities are arranged in a pattern according to a dosage dispense sequence for a medication from the container, and to a type of a medication to be dispensed from the container; and a marking along a side of the pattern, the marking indicative of the dosage dispense sequence corresponding to one or more cavities aligned with the marking in the pattern. A method for using the above device to dispense medication to a patient is also provided.

Abstract: Example systems are described in which a personal protective equipment (PPE) respirator device includes one or more sensor arranged within the PPE to detect exhalation breath temperature of a user, and a computing device configured to generate, based on the detected exhalation breath temperature, a metric indicative of core body temperature of the user wearing the PPE.

Abstract: This disclosure relates to systems and methods of towing, hitching, and connecting devices. In particular, this disclosure relates to tow devices, hitches, and connections for towing item containers behind vehicles, both autonomous and manually guided.

Abstract: The present disclosure generally relates to methods, systems and compositions for determining the presence or absence of prostate cancer in a subject, treating prostate cancer in a subject, and monitoring the efficacy of a treatment regimen for prostate cancer in a subject. The methods of the present disclosure comprise determining the expression levels and spatial locations of two or more analytes in a sample from a subject and correlating the expression levels and spatial locations to a prostate sample from a subject, thereby determining the presence or absence of prostate cancer, determining a treatment regimen for prostate cancer, or monitoring the efficacy of an existing treatment regimen in a subject undergoing treatment for prostate cancer.

Abstract: This invention generally provides two tactile stimulation modules, or “tappers”. One tapper is held by a person in each of his hands. Alternatively, a tapper is secured to each wrist or to other parts of the body on opposite sides. Each tapper is powered by a rechargeable battery, and contains both a tactile stimulation transducer, such as an electric motor having either a balanced or unbalanced mass on its output shaft, and a transceiver that communicates with a host or master. Each tapper includes at least one control button and a status indicator. Each tapper contains a micro-controller that performs tasks such as communication, motor activation, user monitoring and control, battery monitoring, low-power sleep, and algorithm execution. At least one tapper can contain at least one optional sensor, which measures a physiological function. Measurements can be used to modify performance of the tactile stimulation transducers.

Abstract: A ring-shaped cushion for a hearing protector or audio headset. The cushion has a circumferential contact pad for sealing on a wearer's head and an attachment for sealing with an earmuff. The cushion further has a sound insulation tube that inwardly defines an inner space. The sound insulation tube extends between the contact pad and the attachment. The cushion has a ventilation passage that extends entirely through the cushion between an inlet opening in the contact pad and an area outside of the inner space. The cushion may further include one or more physiological sensors to monitor the health of a wearer.

Abstract: A computer-implemented tool for use with an medical device having a computer system, the tool including an unsecured software-implemented suite of diagnostic tools and utilities configured to read logs, read system configuration provide a Telnet function, eject USB, and deactivate itself, and a secured software-implemented suite of diagnostic tools and utilities configured to interpret a key file received from an external source, upload the tool into the computer system of the medical device, run the tool upon booting up of the computer system to enable a replacement component in the medical device to be activated after installation in the medical device.

Abstract: The invention provides (aza)indazolyl-aryl sulfonamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting GCN2 activity.

Abstract: A UV reactor for disinfecting water. The UV reactor may include a cooling chamber in which heat from a UV source may be transferred to the water flowing through the UV reactor. The UV reactor may include driver circuitry operable to determine status information, such as health, of the UV source. The UV reactor may include a gas discharge path operable to substantially prevent accumulation of gas within a water treatment chamber.

Abstract: This disclosure relates to systems and methods of towing, hitching, and connecting devices. In particular, this disclosure relates to tow devices, hitches, and connections for towing item containers behind vehicles, both autonomous and manually guided.

Abstract: This disclosure relates to systems and methods of towing, hitching, and connecting devices. In particular, this disclosure relates to tow devices, hitches, and connections for towing item containers behind vehicles, both autonomous and manually guided.

Abstract: A dispensing system includes a first metering system including a first housing, a first metering rod at least partially disposed within the first housing, and a first assembly defining a first metering chamber and releasably connected to the first housing. The first metering rod linearly translates through the first metering chamber so as to dispense a discrete amount of a first material from the first metering chamber. The dispensing system also includes a second metering system including a second housing, a second metering rod at least partially disposed within the second housing, and a second assembly defining a second metering chamber and releasably connected to the second housing. The second metering rod linearly translates through the second metering chamber so as to dispense a discrete amount of a second material from the second metering chamber. The first metering system is releasably connected to the second metering system.

Abstract: Subframe brace apparatus and related assemblies for use with vehicles are disclosed. A disclosed vehicle assembly includes a subframe of a vehicle, a vehicle body structure, and a brace attaching the subframe to the vehicle body structure. A body of the brace includes a first end coupled to the subframe and a second end coupled to the vehicle body structure. The first end of the body is configured to remain connected to the subframe during an offset frontal vehicle impact event in which the subframe applies a first load to the first end. The first end of the body is also configured to separate from the subframe during a full frontal vehicle impact event in which the subframe applies a second load to the first end.

Abstract: A UV reactor for disinfecting water. The UV reactor may include a cooling chamber in which heat from a UV source may be transferred to the water flowing through the UV reactor. The UV reactor may include driver circuitry operable to determine status information, such as health, of the UV source. The UV reactor may include a gas discharge path operable to substantially prevent accumulation of gas within a water treatment chamber.

Abstract: A device including a portable frame, comprising a tray and a lid that closes upon the tray, and multiple cavities formed in the tray and configured to receive a container is provided. The cavities are arranged in a pattern according to a dosage dispense sequence for a medication from the container, and to a type of a medication to be dispensed from the container; and a marking along a side of the pattern, the marking indicative of the dosage dispense sequence corresponding to one or more cavities aligned with the marking in the pattern. A method for using the above device to dispense medication to a patient is also provided.