Abstract: The invention relates to medical therapy using an agonist of the retinoic acid receptor-related orphan receptor gamma (ROR?) and provides adoptive cellular therapies using an agonist of ROR?, populations of lymphocyte cells that have been exposed to an agonist of ROR?, populations of dendritic cells that have been exposed to an agonist of ROR?, pharmaceutical compositions, and methods for enhancing therapeutic effects of lymphocyte cells and/or dendritic cells in a patient by administering an agonist of ROR? to a patient.

Abstract: A catheter system including a housing and a drive mechanism supported by the housing is provided. The drive mechanism includes an engagement structure configured to engage and to impart movement to a guide wire. The engagement structure defines a path for the guide wire, and the engagement structure is moveable between an engaged position in which the engagement structure engages the guide wire and a disengaged position in which the engagement structure does not engage the guide wire. The catheter system includes a biasing element configured to bias the engagement structure toward the engaged position, and the biasing element is aligned generally parallel to the path defined by the engagement structure.

Abstract: A remote device in accordance with the present invention includes an adaptive power receiver that receives wireless power from the wireless power supply by induction. The adaptive power receiver may be switched among two or more modes of operation, including, for example, a high-Q mode and a low-Q mode. By controlling the switching between modes, the amount of energy received by the adaptive receiver may be controlled. This control is a form of adaptive resonance control or Q control.

Abstract: Featured is an inventive anchor/implant deployment device for use in repairing damage to tissue (e.g., meniscus) as well as tissue repair methods related thereto. Such an anchor/implant deployment device is advantageously configured and arranged so the deployment device is capable of making at least an in situ adjustment to the path of a needle portion having the anchor(s)/implant(s); is capable of rotating such a needle portion or the portion extending into the tissue/meniscus so that the distal end entering into the tissue/meniscus is desirably oriented such as to, for example, minimize damage to tissue; and making the needle portion of the deployment device replaceable so as to allow the deployment device to be reloaded thereby making other portions of the deployment device reusable during a given, procedure.

Abstract: A wireless remote sensor (110) that is powered by an inductive transmitter (112) and is configured to produce an oscillating wave that varies based on one or more sensed parameters. The oscillating wave is communicated to the inductive transmitter (112) by reflected impedance, where it can be detected to determine the sensed value(s). In another aspect, the present invention provides a wireless remote sensor with a Wheatstone bridge arrangement having an internal resonant circuit to produce an electromagnetic field indicative of the sensed value. In a third aspect, the present invention provides a wireless remote sensor with optical feedback from a reference circuit and a sensor circuit. In a fourth aspect, the present invention provides a wireless remote temperature sensor having coils printed on a material with a high coefficient of thermal expansion so that the size and/or shape of the coils varies as the temperature increases or decreases.

Abstract: A vehicle includes a rocker support that extends in a vehicle longitudinal direction. A side roof rail structure extends in a vehicle longitudinal direction along a vehicle roof assembly. A front pillar assembly is coupled to and extends upward from the rocker support to the side roof rail structure. The front pillar assembly includes a first panel that extends along a height of the front pillar assembly at a front side of the front pillar assembly. A second panel extends along the height of the front pillar assembly that is connected to the first panel at least partially defining an enclosed cavity that extends along the height of the front pillar assembly. The first panel is formed of a material having a lower minimum tensile strength than a material forming the second panel thereby forming a zone of reduced minimum tensile strength along the front side of the front pillar assembly.

Abstract: The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

Abstract: The invention provides dihydro-2H-benzo[b] [1,4]oxazine sulfonamide and related compounds, pharmaceutical compositions, methods of promoting ROR? activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

Abstract: Techniques to sort events of a graphics workload executed by a graphics processing unit to provide identification of events, that if addressed, may result in an improvement in performance are disclosed. The techniques can include: generating a signature and a weight for each event of a graphics workload; generating an event priority tree by organizing the events into parent and leaf nodes, where parent nodes comprise leaf nodes having a shared hash; and sorting frames based on a global weight of events corresponding to the frames.

Abstract: A cannulated retrograde reamer that is adjustable to create tunnels of multiple different diameters. The cannulated retrograde reamer substantially reduces the risk of tunnel malposition and/or misalignment, and can be adjusted to create a range of tunnel diameters, thereby allowing inventory levels to be reduced for a surgical case.

Abstract: The invention provides pyrazolyl guanidine compounds that inhibit F1F0-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.

Abstract: The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

Abstract: A system receives a user identifier and a link identifier to identify a machine-readable link in an image captured by a first device. In response to determining that the user identifier indicates a user having an administrative privilege with respect to the machine-readable link, the system sends, to the first device, a response containing information to allow performance of management with respect to the machine-readable link.

Abstract: An electrical receptacle providing standard alternating current (AC) power connectors and multiple side-mounted auxiliary ports. Auxiliary ports may include direct current (DC) power delivery means, such as USB ports, and/or unpowered ports, such as audio/visual equipment connectors or network ports.

Abstract: A cannulated retrograde reamer that is adjustable to create tunnels of multiple different diameters. The cannulated retrograde reamer substantially reduces the risk of tunnel malposition and/or misalignment, and can be adjusted to create a range of tunnel diameters, thereby allowing inventory levels to be reduced for a surgical case.

Abstract: A catheter system including a housing and a drive mechanism supported by the housing is provided. The drive mechanism includes an engagement structure configured to engage and to impart movement to a guide wire. The engagement structure defines a path for the guide wire, and the engagement structure is moveable between an engaged position in which the engagement structure engages the guide wire and a disengaged position in which the engagement structure does not engage the guide wire. The catheter system includes a biasing element configured to bias the engagement structure toward the engaged position, and the biasing element is aligned generally parallel to the path defined by the engagement structure.

Abstract: A remote device in accordance with the present invention includes an adaptive power receiver that receives wireless power from the wireless power supply by induction. The adaptive power receiver may be switched among two or more modes of operation, including, for example, a high-Q mode and a low-Q mode. By controlling the duty cycle of the switching between modes, the amount of energy received by the adaptive receiver may be controlled to communicate to the wireless power supply. This control is a form of adaptive resonance communication or Q control communication. Distortion can be reduced or eliminated by ramping between duty cycles with adjustment to intermediate duty cycle values.

Abstract: Provided herewith is a process for improving tensile strength of precursor PAN fiber during the spinning stage in the manufacturing process. According to the process of the present invention, precursor fiber is made denser as it enters each wash bath. This progressive densification approach is useful for all PAN precursor bath draw/wash processes where a need for careful control of fiber network density and structure is required for improved carbon fiber properties.

Abstract: A vehicle includes a rocker support that extends in a vehicle longitudinal direction. A side roof rail structure extends in a vehicle longitudinal direction along a vehicle roof assembly. A front pillar assembly is coupled to and extends upward from the rocker support to the side roof rail structure. The front pillar assembly includes a first panel that extends along a height of the front pillar assembly at a front side of the front pillar assembly. A second panel extends along the height of the front pillar assembly that is connected to the first panel at least partially defining an enclosed cavity that extends along the height of the front pillar assembly. The first panel is formed of a material having a lower minimum tensile strength than a material forming the second panel thereby forming a zone of reduced minimum tensile strength along the front side of the front pillar assembly.

Abstract: The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit F1F0-ATPase, and methods of using trifluoromethyl pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.