Abstract: A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.

Abstract: A dispersive mixing element for co-rotating twin screw extruder is disclosed. The element for co-rotating twin screw extruder comprises of a continuous flight helically formed thereon having a lead ‘L’, wherein either the flight transforms at least once from an integer lobe flight into a non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to an integer lobe flight in a fraction of the lead ‘L’ or the flight transforms at least once from a non-integer lobe flight into an integer lobe flight in a fraction of the lead ‘L’ and transforms back to a non-integer lobe flight in a fraction of the lead ‘L’.

Abstract: A process for preparing hydrogels is disclosed. Said process comprises passing reactants comprising a monomer, an initiator and a cross-linker through a co-rotating twin screw extruder, the co-rotating twin screw extruder being operated at a screw speed of at least 200 rpm and comprising an inlet zone, an outlet zone, and in between the inlet zone and the outlet zone at least one mixing zone, at least one conveying zone and at least one back-mixing zone, wherein the back-mixing zone comprises of restricting elements which restrict the reactants from moving forward in the co-rotating twin screw extruder until a forward force sufficient to overcome the restriction is achieved, such that the co-rotating twin screw extruder provides sufficient shear energy and residence time to the reactants to (co)polymerize and produce hydrogel having a water uptake greater than 100 g/g.

Abstract: An element for a co-rotating twin screw processor, the element having a lead ‘L’ and at least one continuous flight helically formed thereon and, wherein the flight transforms at least once from a first non-integer lobe flight into a second non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to the first non-integer lobe flight in a fraction of the lead ‘L’.

Abstract: A rapidly disintegrating tablet comprising a therapeutically effective amount of a DPP-IV inhibitor and an acid-base couple having mineral content below the daily intake limits is disclosed. The rapidly disintegrating tablet has a sodium content less than 10 mg and a potassium content less than 15 mg. A process for preparation of the rapidly disintegrating tablet comprising the DPP-IV inhibitor is also disclosed.

Abstract: A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.

Abstract: A dispersive mixing element for co-rotating twin screw extruder is disclosed. The element for co-rotating twin screw extruder comprises of a continuous flight helically formed thereon having a lead ‘L’, wherein either the flight transforms at least once from an integer lobe flight into a non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to an integer lobe flight in a fraction of the lead ‘L’ or the flight transforms at least once from a non-integer lobe flight into an integer lobe flight in a fraction of the lead ‘L’ and transforms back to a non-integer lobe flight in a fraction of the lead ‘L’.

Abstract: The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor.

Abstract: A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.

Abstract: A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.

Abstract: The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.

Abstract: An element for a co-rotating twin screw processor, the element having a lead ‘L’ and at least one continuous flight helically formed thereon and, wherein the flight transforms at least once from a first non-integer lobe flight into a second non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to the first non-integer lobe flight in a fraction of the lead ‘L’.

Abstract: A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.

Abstract: A barrel alignment structure for a pair of barrel sections each defining an end surface configured to abut each other is disclosed. The barrel alignment structure comprises of a plurality of alignment pins distributed on the end surface of the first barrel section. The barrel alignment structure further comprises of a corresponding number of slots defined on the end surface of the second barrel section, each slot configured to receive one alignment pin, wherein the slot has a width substantially equal to that of the alignment pin and a length larger than the width of the alignment pin permitting relative thermal expansion between the pair of barrel sections. An extruder barrel section is also disclosed. The extruder barrel section defining an end surface configured to abut the end surface of another extruder barrel section. The extruder barrel section comprises of a plurality of alignment pins distributed on its end surface.

Abstract: An extruder barrel section is disclosed. The extruder barrel section comprises of a first barrel pad and a second barrel pad. The first and second barrel pad co-operating to define a recess configured to receive an extruder liner. The length of the first and second barrel pad is less than the length of the extruder liner such that the extruder liner defines an end surface that projects beyond the extruder barrel section on at least one side. The end surface is configured to abut the end surface of another extruder liner. The extruder barrel section further comprises of a locking structure configured to lock the first barrel pad to the second barrel pad with the extruder liner therebetween.

Abstract: A system for efficient torque transmission, consisting of at least one driving member and at least one driven member, which uses a complementing spline profile having almost nil stress concentration which enhances the overall torque transmission capacity of a shaft with a given diameter.

Abstract: A dispersive mixing element for co-rotating twin screw extruder is disclosed. The element for co-rotating twin screw extruder comprises of a continuous flight helically formed thereon having a lead ‘L’, wherein either the flight transforms at least once from an integer lobe flight into a non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to an integer lobe flight in a fraction of the lead ‘L’ or the flight transforms at least once from a non-integer lobe flight into an integer lobe flight in a fraction of the lead ‘L’ and transforms back to a non-integer lobe flight in a fraction of the lead ‘L’.

Abstract: An extruder configuration system is disclosed. The system includes an extruder information database including details of extruders, extruder elements and extruder barrels, a user interface configured to receive user inputs including user choices of extruders, extruder elements or extruder barrels from the extruder information database, the user interface further configured to receive extruders, extruder elements or extruder barrels for addition to the extruder information database, an element positioning engine including a database of incompatible elements and configured to review user choices and prevent positioning of incompatible extruder elements adjacent to each other on an extruder, a processor configured to create an extruder configuration based on user inputs and a display module configured to display the extruder configuration.

Abstract: An extruder configuration system is disclosed. The system includes an extruder information database including details of extruders, extruder elements and extruder barrels, a user interface configured to receive user inputs including user choices of extruders, extruder elements or extruder barrels from the extruder information database, the user interface further configured to receive extruders, extruder elements or extruder barrels for addition to the extruder information database, an element positioning engine including a database of incompatible elements and configured to review user choices and prevent positioning of incompatible extruder elements adjacent to each other on an extruder, a processor configured to create an extruder configuration based on user inputs and a display module configured to display the extruder configuration.

Abstract: A system for clamping together a pair of extruder barrel sections of an extruder is disclosed. The system comprises of a clamp that includes an upper arm, and a lower arm connected to the upper arm at one edge of the upper arm. The upper and lower arms cooperating to define a recess configured to receive a pair of extruder barrel sections. The clamp further includes a locking structure configured to lock the upper arm to the lower arm with the pair of extruder barrel sections therebetween. The system further comprises of a support structure for the clamp that includes a bracket connected to the clamp and a column connected to a base of the extruder. The bracket and column are connected to each other such that relative movement between the bracket and the column is permitted axially along the extruder barrels sections. An extruder is also disclosed.