Patents by Inventor Baihua Hu

Baihua Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7332521
    Abstract: The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: February 19, 2008
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Publication number: 20070299126
    Abstract: The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them.
    Type: Application
    Filed: July 27, 2007
    Publication date: December 27, 2007
    Applicant: WYETH
    Inventor: Baihua Hu
  • Publication number: 20070299125
    Abstract: The present invention relates generally to substituted indoles and methods of using them.
    Type: Application
    Filed: July 27, 2007
    Publication date: December 27, 2007
    Applicant: WYETH
    Inventors: Baihua Hu, James Jetter
  • Patent number: 7285682
    Abstract: The present invention provides terphenyl guanidine compounds of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: October 23, 2007
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Patent number: 7268159
    Abstract: The present invention relates generally to substituted indoles and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: September 11, 2007
    Assignee: Wyeth
    Inventors: Baihua Hu, James Winfield Jetter
  • Patent number: 7265148
    Abstract: The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: September 4, 2007
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Publication number: 20070043101
    Abstract: The present invention relates generally to substituted indoles and methods of using them.
    Type: Application
    Filed: August 16, 2006
    Publication date: February 22, 2007
    Applicant: WYETH
    Inventors: Baihua Hu, James Jetter
  • Publication number: 20060252757
    Abstract: This invention relates generally to cinnoline-based modulators of Liver X receptors (LXRs) and related methods.
    Type: Application
    Filed: March 1, 2006
    Publication date: November 9, 2006
    Inventors: Baihua Hu, Jay Wrobel, Michael Collini, Rayomand Unwalla
  • Patent number: 7101875
    Abstract: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: September 5, 2006
    Assignee: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Publication number: 20060183943
    Abstract: The present invention provides terphenyl guanidine compounds of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: February 13, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventor: Baihua Hu
  • Patent number: 7022716
    Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: April 4, 2006
    Assignee: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael Sotirios Malamas
  • Publication number: 20060014759
    Abstract: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.
    Type: Application
    Filed: May 27, 2005
    Publication date: January 19, 2006
    Applicant: Wyeth
    Inventors: John McKew, Steven Tam, Katherine Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James Clark, Wei Li, Valerie Clerin, Suzana Marusic, Kevin Pong
  • Patent number: 6984735
    Abstract: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: January 10, 2006
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark, Wei Li
  • Publication number: 20050131014
    Abstract: This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.
    Type: Application
    Filed: December 10, 2004
    Publication date: June 16, 2005
    Applicant: Wyeth
    Inventors: Michael Collini, Robert Singhaus, Baihua Hu, James Jetter, Robert Morris, David Kaufman, Christopher Miller, John Ullrich, Rayomand Unwalla, Jay Wrobel, Elaine Quinet, Ponnal Nambi, Ronald Bernotas, Merle Elloso
  • Publication number: 20050119327
    Abstract: The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them.
    Type: Application
    Filed: September 23, 2004
    Publication date: June 2, 2005
    Applicant: WYETH
    Inventor: Baihua Hu
  • Publication number: 20050113438
    Abstract: The present invention relates generally to substituted indoles and methods of using them.
    Type: Application
    Filed: September 23, 2004
    Publication date: May 26, 2005
    Applicant: WYETH
    Inventors: Baihua Hu, James Jetter
  • Publication number: 20050113439
    Abstract: The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them.
    Type: Application
    Filed: September 23, 2004
    Publication date: May 26, 2005
    Applicant: WYETH
    Inventor: Baihua Hu
  • Publication number: 20050096377
    Abstract: The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.
    Type: Application
    Filed: September 23, 2004
    Publication date: May 5, 2005
    Applicant: WYETH
    Inventor: Baihua Hu
  • Patent number: 6821991
    Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: November 23, 2004
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Patent number: 6797708
    Abstract: This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: September 28, 2004
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark