Patents by Inventor Baihua Hu

Baihua Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia
    Publication number: 20040110780
    Abstract: This invention provides compounds of Formula I having the structure: 1
    Type: Application
    Filed: September 4, 2003
    Publication date: June 10, 2004
    Applicant: Wyeth
    Inventor: Baihua Hu
  • Process for making an aldehyde
    Publication number: 20040082785
    Abstract: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.
    Type: Application
    Filed: November 26, 2003
    Publication date: April 29, 2004
    Applicant: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark, Wei Li
  • N-benzhydryl indole compounds
    Patent number: 6635771
    Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: October 21, 2003
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
    Publication number: 20030176412
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: May 19, 2003
    Publication date: September 18, 2003
    Applicant: Wyeth
    Inventor: Baihua Hu
  • Methods for treating arthritic disorders
    Publication number: 20030166649
    Abstract: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: September 4, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • N-BENZHYDRYL INDOLE COMPOUNDS
    Publication number: 20030158405
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 21, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Methods for treating asthmatic conditions
    Publication number: 20030149029
    Abstract: This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 7, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of cytosolic phospholipase A2
    Publication number: 20030144282
    Abstract: This invention provides substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Publication number: 20030144326
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: December 27, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael Sotirios Malamas
  • 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
    Patent number: 6583140
    Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: June 24, 2003
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Patent number: 6525202
    Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: February 25, 2003
    Assignee: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael S. Malamas
  • Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
    Publication number: 20030027797
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: September 5, 2002
    Publication date: February 6, 2003
    Applicant: Wyeth
    Inventors: Fuk-Wah Sum, Baihua Hu
  • Cyclamine sulfonamides as &bgr;-3 adrenergic receptor agonists
    Patent number: 6498170
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: December 24, 2002
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Baihua Hu
  • 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
    Publication number: 20020169325
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: April 25, 2002
    Publication date: November 14, 2002
    Applicant: Wyeth
    Inventor: Baihua Hu
  • 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
    Patent number: 6410734
    Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: June 25, 2002
    Assignee: Wyeth
    Inventor: Baihua Hu
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Publication number: 20020028835
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: March 7, 2002
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael S Malamas
  • Cyclamine sulfonamides as beta-3 adrenergic receptor agonists
    Publication number: 20020022605
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: February 21, 2002
    Applicant: American Home Products Corporation
    Inventors: Fuk-Wah Sum, Baihua Hu
  • N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
    Patent number: 6172057
    Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-&agr; converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-&agr; converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: January 9, 2001
    Assignee: American Cyanamid Company
    Inventors: Aranapakam Mudumbai Venkatesan, George Theodore Grosu, Jamie Marie Davis, Baihua Hu, Derek Cecil Cole, Jannie Lea Baker, Marcy Pamela Jacobson, Matthew Robin O'Dell