Patents by Inventor Balwant Singh

Balwant Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4708984
    Abstract: Novel beta-hydroxyalkylcarbamylmethyl aminotriazines function in self-condensation and as crosslinkers for amino resins and also compounds containing active hydrogen groups. The compositions cure to coatings with excellent properties, and they can be used as binders for fillers such as insulating glass and foundry sand.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: November 24, 1987
    Assignee: American Cyanamid Company
    Inventors: Peter S. Forgione, Balwant Singh
  • Patent number: 4633010
    Abstract: 1,3,5-Tris(1-isocyanatomethylethyl)benzene is disclosed as a component in coating formulations and the like.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: December 30, 1986
    Assignee: American Cyanamid Company
    Inventors: Balwant Singh, Peter S. Forgione
  • Patent number: 4620009
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.
    Type: Grant
    Filed: October 1, 1981
    Date of Patent: October 28, 1986
    Assignee: Cyanamid Agricultural de Puerto Rico, Inc.
    Inventors: Sivaraman Raghu, Arthur K. Hoffmann, Balwant Singh
  • Patent number: 4578513
    Abstract: A new and improved process for making phenylisopropylurea derivatives having the formula: ##STR1## wherein R.sup.1 is selected from hydrogen, halogen, alkyl, alkenyl, haloalkyl or R.sup.2 groups and R.sup.2 is selected from phenyl, alkyl-substituted phenyl alkoxy-substituted phenyl or haloalkyl-substituted phenyl is disclosed. The process comprises reacting a substituted urea of the formula: ##STR2## with an alkenyl aromatic compound of the formula: ##STR3## in a polar aprotic solvent, in the presence of an acid catalyst, preferably, sulfuric acid, substituted sulfonic acids or Lewis acids, and stirring the reaction mixture at a temperature of about 20.degree. to 80.degree. C. until formation of the precipitated phenylisopropylurea derivative is substantially complete.
    Type: Grant
    Filed: November 16, 1984
    Date of Patent: March 25, 1986
    Assignee: American Cyanamid Company
    Inventors: Balwant Singh, Paul S. Waterman
  • Patent number: 4570012
    Abstract: Production of tertiary aralkyl urethanes, such as tetramethyl xylylene diurethanes, by addition of corresponding diols and carbamic acid esters at moderate temperatures and in the presence of acid catalyst.
    Type: Grant
    Filed: February 24, 1984
    Date of Patent: February 11, 1986
    Assignee: American Cyanamid Co.
    Inventors: Balwant Singh, Peter S. Forgione, Laurence W. Chang
  • Patent number: 4547265
    Abstract: A method of sizing paper, comprising applying thereto a sizingly effective amount of a polymer selected from the group consisting of:(a) homopolymers of .alpha.,.alpha.-dimethyl-m-isopropenyl benzyl amine or .alpha.,.alpha.-dimethyl-p-isopropenyl benzyl amine;(b) copolymers of (i) .alpha.,.alpha.-dimethyl-m-isopropenyl benzyl amine or .alpha.,.alpha.-dimethyl-p-isopropenyl benzylamine, and (ii) at least one other ethylenically unsaturated monomer copolymerizable therewith; and(c) acid salts of said homopolymers (a) and copolymers (b).Such homopolymers or copolymers suitably may be prepared as the hydrolysis reaction products of the corresponding homopolymeric or copolymeric isocyanates.
    Type: Grant
    Filed: June 1, 1983
    Date of Patent: October 15, 1985
    Assignee: American Cyanamid Company
    Inventors: Peter S. Forgione, Balwant Singh, John A. Sedlak
  • Patent number: 4439616
    Abstract: Production of tertiary aralkyl isocyanates, such as tetramethyl xylylene diisocyanates, by thermal cracking of corresponding urethanes formed by addition of corresponding olefins and carbamic acid esters at moderate temperatures and in the presence of acid catalyst.
    Type: Grant
    Filed: July 22, 1982
    Date of Patent: March 27, 1984
    Assignee: American Cyanamid Company
    Inventors: Balwant Singh, Laurence W. Chang, Peter S. Forgione
  • Patent number: 4395369
    Abstract: A process for production of tertiary aralkyl isocyanates by reaction at low temperatures of the corresponding halides with an excess of isocyanic acid. Manufacture of TMXDI is specifically contemplated.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: July 26, 1983
    Assignee: American Cyanamid Company
    Inventors: William A. Henderson, Jr., Balwant Singh
  • Patent number: 4374987
    Abstract: An improved process for the preparation and purification of N-{p-([2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as methotrexate, using the alkali metal, calcium and zinc salts of N-methyl-p-aminobenzoylglutamate, tetraaminopyrimidine sulfate, 1,1,3-tribromoacetone and the alkali metal and zinc salts of methotrexate.
    Type: Grant
    Filed: August 14, 1980
    Date of Patent: February 22, 1983
    Assignee: American Cyanamid Company
    Inventors: Balwant Singh, Frederic C. Schaefer
  • Patent number: 4374771
    Abstract: The novel compound, N,N'-methylenebis (hexahydro-2-oxo-1H-azepine-1-carboxamide) which is useful as a blocked isocyanate to introduce the functionality of methylene diisocyanate and which is prepared by the reaction of isocyanic acid and caprolactam followed by reaction with formaldehyde.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: February 22, 1983
    Assignee: American Cyanamid Company
    Inventors: Balwant Singh, Robert W. Novak
  • Patent number: 4370482
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazols, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.
    Type: Grant
    Filed: October 28, 1981
    Date of Patent: January 25, 1983
    Assignee: American Cyanamid Co.
    Inventors: Sivaraman Raghu, Arthur K. Hoffmann, Balwant Singh
  • Patent number: 4361518
    Abstract: A process for production of tertiary benzyl isocyanates by reaction at low temperatures of the corresponding halides with an excess of isocyanic acid.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: November 30, 1982
    Assignee: American Cyanamid Company
    Inventors: Balwant Singh, William A. Henderson, Jr.
  • Patent number: 4359575
    Abstract: Isocyanic acid is trimerized to cyanuric acid by contacting the isocyanic acid with liquid organic solvent, preferably polar solvent having high dielectric constant. The product is recovered as precipitate of good purity. Conversion and yield are high.
    Type: Grant
    Filed: May 21, 1981
    Date of Patent: November 16, 1982
    Assignee: American Cyanamid Company
    Inventors: Ronald A. Sills, Daniel S. Katz, Balwant Singh
  • Patent number: 4314066
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.
    Type: Grant
    Filed: February 15, 1978
    Date of Patent: February 2, 1982
    Assignee: American Cyanamid Co.
    Inventors: Sivaraman Raghu, Arthur K. Hoffmann, Balwant Singh
  • Patent number: 4310672
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, di-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.
    Type: Grant
    Filed: March 17, 1980
    Date of Patent: January 12, 1982
    Assignee: American Cyanamid Co.
    Inventors: Sivaraman Raghu, Arthur K. Hoffmann, Balwant Singh
  • Patent number: 4150030
    Abstract: This invention relates to the preparation of optically active d-2-aminobutanol by catalytic asymmetric reduction of appropriate dehydro precursors to produce selectively the desired isomer. The same substrates can also be used to prepare the dl-mixture using optically inactive catalysts. The novel substituted-4-ethyl-4-oxazolin-2-one and substituted-4-ethyl-2-oxazolidinone compounds of this invention are useful as intermediates in the production of the antituberculosis drug ethambutol (Myambutol.RTM.).
    Type: Grant
    Filed: April 12, 1977
    Date of Patent: April 17, 1979
    Assignee: American Cyanamid Company
    Inventor: Balwant Singh
  • Patent number: 4139707
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: February 13, 1979
    Assignee: American Cyanamid Company
    Inventors: Sivaraman Raghu, Arthur K. Hoffmann, Balwant Singh
  • Patent number: 4090025
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 16, 1978
    Assignee: American Cyanamid Company
    Inventors: Sivaraman Raghu, Arthur Kentaro Hoffmann, Balwant Singh
  • Patent number: 4087611
    Abstract: A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: May 2, 1978
    Assignee: American Cyanamid Company
    Inventors: Sivaraman Raghu, Arthur Kentaro Hoffmann, Balwant Singh
  • Patent number: 3944617
    Abstract: DL-2-Amino-1-butanol, as the free base or a salt, for resolution to d-2-amino-1-butanol, for the synthesis of ethambutol hydrochloride, d,d'-2,2'-(ethylenediimino)di-1-butanol dihydrochloride, is produced in high purity and good yields by the reaction of butene-1, a nitrile, preferably an excess of acetonitrile, and chlorine to form N-[1-(chloromethyl)propyl]acetimidoyl chloride which is hydrolyzed to dl-2-amino-1-butanol hydrochloride. This can be isolated as the hydrochloride, or free base, or a mixture, resolved with L(+)- tartaric acid and the d-2-amino-1-butanol reacted with ethylene dichloride and then hydrochloric acid to form ethambutol hydrochloride. A minimum of by-products which are conveniently split out permits the economical synthesis of a pharmaceutical grade product.
    Type: Grant
    Filed: August 1, 1974
    Date of Patent: March 16, 1976
    Assignee: American Cyanamid Company
    Inventor: Balwant Singh