Patents by Inventor Barbara S. Slusher

Barbara S. Slusher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiolactones
    Patent number: 7125907
    Abstract: This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-? activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: October 24, 2006
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Takashi Tsukamoto
  • Thiol-based NAALADase inhibitors
    Patent number: 6992215
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: January 31, 2006
    Assignee: Guildford Pharmaceuticals Inc.
    Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
  • Benzenedicarboxylic acid derivatives
    Patent number: 6852750
    Abstract: New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-? activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: February 8, 2005
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Paul F. Jackson, Takashi Tsukamoto, Barbara S. Slusher, Eric Wang
  • Thiol-based NAALADase inhibitors
    Patent number: 6812364
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: November 2, 2004
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
  • Methods for treating certain diseases using naaladase inhibitors
    Patent number: 6806261
    Abstract: The present invention relates to methods for regulating the release of TGF-&bgr; from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or for preventing or treating diabetes.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: October 19, 2004
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Xi-Chun May Lu, Krystyna Wozniak
  • Naaladase inhibitors for treating opioid tolerance
    Publication number: 20040186081
    Abstract: The present invention relates to pharmaceutical compositions and methods for treating opioid tolerance using NAALADase inhibitors.
    Type: Application
    Filed: March 3, 2004
    Publication date: September 23, 2004
    Applicant: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Krystyna Wozniak
  • Thiol-based NAALADase inhibitors
    Publication number: 20030216468
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Application
    Filed: May 8, 2003
    Publication date: November 20, 2003
    Applicant: GUILFORD PHARMACEUTICALS INC.
    Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
  • Thiol-based NAALADase inhibitors
    Patent number: 6586623
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: July 1, 2003
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
  • Thiol-based NAALADase inhibitors
    Publication number: 20030105088
    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
    Type: Application
    Filed: January 17, 2002
    Publication date: June 5, 2003
    Applicant: GUILFORD PHARMACEUTICALS INC.
    Inventors: Takashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
  • Benzenedicarboxylic acid derivatives
    Publication number: 20030083505
    Abstract: New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
    Type: Application
    Filed: June 21, 2002
    Publication date: May 1, 2003
    Inventors: Paul F. Jackson, Takashi Tsukamoto, Barbara S. Slusher, Eric Wang
  • NAALADase inhibitors useful as pharmaceutical compounds and compositions
    Publication number: 20030083374
    Abstract: The present invention relates to N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
    Type: Application
    Filed: June 10, 2002
    Publication date: May 1, 2003
    Inventors: Paul F. Jackson, Keith M. Maclin, Eric Wang, Barbara S. Slusher, Rena S. Lapidus, Pavel Majer
  • Pharmaceutical compositions and methods of inhibiting angiogenesis using NAALADase inhibitors
    Publication number: 20030064912
    Abstract: The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angiogenic effective amount of a NAALADase inhibitor and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 11, 2002
    Publication date: April 3, 2003
    Inventors: Barbara S. Slusher, Rena Lapidus
  • Naaladase inhibitors for treating retinal disorders and glaucoma
    Publication number: 20030036534
    Abstract: The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
    Type: Application
    Filed: May 30, 2001
    Publication date: February 20, 2003
    Inventors: Barbara S. Slusher, Krystyna Wozniak
  • Methods for treating certain diseases using naaladase inhibitors
    Publication number: 20030017965
    Abstract: A method for regulating the release of TGF-&bgr; from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or preventing or treating diabetes.
    Type: Application
    Filed: August 1, 2002
    Publication date: January 23, 2003
    Inventors: Barbara S. Slusher, Xi-Chun May Lu, Krystyna Wozniak
  • Pharmaceutical compositions and methods for treating anxiety, anxiety disorders and memory impairment using NAALADase inhibitors
    Publication number: 20030013687
    Abstract: The present invention relates to pharmaceutical compositions and methods of using NAALADase inhibitors for treating glutamate-mediated diseases, disorders and conditions selected from the group consisting of anxiety, anxiety disorders and memory impairment.
    Type: Application
    Filed: February 20, 2002
    Publication date: January 16, 2003
    Inventor: Barbara S. Slusher
  • NAALADase inhibitors
    Patent number: 6479471
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: November 12, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Methods of cancer treatment using naaladase inhibitors
    Publication number: 20020151503
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Application
    Filed: January 28, 2002
    Publication date: October 17, 2002
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin
  • NAALADase inhibitors useful as pharmaceutical compounds and compositions
    Patent number: 6458775
    Abstract: The present invention relates to N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: October 1, 2002
    Assignee: Guilford Pharmaceutical Inc.
    Inventors: Paul F. Jackson, Keith M. Maclin, Eric Wang, Barbara S. Slusher, Rena S. Lapidus, Pavel Majer
  • Benzenedicarboxylic acid derivatives
    Patent number: 6452044
    Abstract: New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neutopathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: September 17, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Takashi Tsukamoto, Barbara S. Slusher, Eric Wang
  • Methods for treating certain diseases using naaladase inhibitors
    Patent number: 6444657
    Abstract: The present invention relates to methods of using NAALADase inhibitors to regulate TGF-&bgr; and to treat neurodegenerative disorders, extracellular matrix formation disorders, cell-growth related diseases, infectious diseases, immune related diseases, epithelial tissue scarring, collagen vascular diseases, fibroproliferative disorders, connective tissue disorders, inflammatory diseases, respiratory distress syndrome and infertility.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: September 3, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Xi-Chun May Lu, Krystyna Wozniak