Patents by Inventor Barbara S. Slusher

Barbara S. Slusher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions and methods of effecting a neuronal activity in an animal using naaladase inhibitors
    Patent number: 6413948
    Abstract: The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor for treating a glutamate abnormality and effecting a neuronal activity in an animal.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: July 2, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin
  • Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
    Patent number: 6395718
    Abstract: The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angiogenic effective amount of a NAALADase inhibitor and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: May 28, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Rena Lapidus
  • Prodrugs of NAALAdase inhibitors
    Patent number: 6384022
    Abstract: The present invention relates to prodrugs of NAALADase inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat glutamate abnormalities and prostate diseases.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: May 7, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher
  • Pharmaceutical compositions and methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
    Patent number: 6376478
    Abstract: The present invention relates to pharmaceutical compositions and methods of using NAALADase inhibitors for treating glutamate-mediated diseases, disorders and conditions selected from the group consisting of anxiety, anxiety disorders and memory impairment.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: April 23, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventor: Barbara S. Slusher
  • Methods of cancer treatment using NAALADase inhibitors
    Patent number: 6372726
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: April 16, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin
  • Pyrrolecarbonylimino derivatives as naaladase inhibitors
    Patent number: 6348464
    Abstract: The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases and cancers.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: February 19, 2002
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher
  • Benzenedicarboxylic acid derivatives
    Publication number: 20020019430
    Abstract: New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neutopathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
    Type: Application
    Filed: May 30, 2001
    Publication date: February 14, 2002
    Inventors: Paul F. Jackson, Takashi Tsukamoto, Barbara S. Slusher, Eric Wang
  • Naaladase inhibitors for treating amyotrophic lateral sclerosis
    Publication number: 20020013295
    Abstract: The present invention relates to pharmaceutical compositions and methods for treating amyotrophic lateral sclerosis using NAALADase inhibitors.
    Type: Application
    Filed: May 30, 2001
    Publication date: January 31, 2002
    Inventors: Barbara S. Slusher, Krystyna Wozniak
  • Hydroxamic acid derivatives
    Publication number: 20010044459
    Abstract: The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Application
    Filed: June 15, 2001
    Publication date: November 22, 2001
    Inventors: Paul F. Jackson, Kevin L. Tays, Keith M. Maclin, Barbara S. Slusher
  • Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
    Patent number: 6313159
    Abstract: The present invention relates to metabotropic glutamate receptor ligand derivatives and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsive disorders, pain, diabetic neuropathy, and prostate diseases, as well as pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: November 6, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher
  • Phosphonic acid derivatives
    Patent number: 6288046
    Abstract: The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 26, 1999
    Date of Patent: September 11, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Keith M. Maclin, Kevin L. Tays, Barbara S. Slusher
  • Hydroxamic acid derivatives
    Patent number: 6271245
    Abstract: The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: August 7, 2001
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Paul F. Jackson, Kevin L. Tays, Keith M. MacLin, Barbara S. Slusher
  • Thio-substituted pentanedioic acid derivatives
    Patent number: 6265609
    Abstract: The present invention relate to thio-substituted pentanedioic acid derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsive disorders and prostate diseases.
    Type: Grant
    Filed: January 12, 1999
    Date of Patent: July 24, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Keith M. Maclin, Eric Wang, Barbara S. Slusher, Rena Lapidus
  • Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
    Patent number: 6228888
    Abstract: The present invention relates to methods of using NAALADase inhibitors for treating glutamate-mediated diseases, disorders and conditions selected from the group consisting of anxiety, anxiety disorders and memory impairment.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: May 8, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventor: Barbara S. Slusher
  • Phosphinic acid derivatives
    Patent number: 6121252
    Abstract: The present invention relate to phosphinic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activity and to treat glutamate abnormalities and prostate diseases.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: September 19, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Takashi Tsukamoto, Yao-Sen Ko, Barbara S. Slusher
  • Phosphinic alkanoic acid derivatives
    Patent number: 6071965
    Abstract: The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activity and to treat glutamate abnormalities and prostate diseases.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: June 6, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Weixing Li, Keith M. Maclin, Kevin L. Tays, Takashi Tsukamoto, Barbara S. Slusher
  • Phosphonic acid derivatives
    Patent number: 6054444
    Abstract: The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: April 25, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Keith M. Maclin, Kevin L. Tays, Barbara S. Slusher
  • NAALADase inhibitors
    Patent number: 6046180
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: April 4, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Certain dioic acid derivatives useful as NAALADase inhibitors
    Patent number: 6025344
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: February 15, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Inhibitors of NAALADase enzyme activity
    Patent number: 6025345
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: February 15, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin