Patents by Inventor Barry A. Morgan

Barry A. Morgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Synthesis of Encoded Libraries
    Publication number: 20200149034
    Abstract: Methods of producing compounds and combinatorial compound libraries, the compounds and libraries produced via the methods are provided, and methods of using the libraries to identify compounds having a desired property, such as a desired biological activity and the compounds identified using these methods are provided.
    Type: Application
    Filed: March 16, 2018
    Publication date: May 14, 2020
    Inventors: Jin Li, Barry A. Morgan, Jinqiao Wan, Dengfeng Dou, Guansai Liu, Yong Chang, Qiuxia Chen, Xing Wang, Yanshan Xu, Dongyan Hu, Jian Liu, Xuemin Cheng
  • sEH inhibitors and their use
    Patent number: 7994317
    Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: August 9, 2011
    Assignee: GlaxoSmithKline, LLC
    Inventors: Yun Ding, Joseph Paul Marino, Jr., Peng Li, Allyn T. Londregan, Barry A. Morgan
  • Prenyl transferase inhibitors
    Patent number: 7691859
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: April 6, 2010
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Novel sEH Inhibitors and Their Use
    Publication number: 20100069391
    Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.
    Type: Application
    Filed: November 2, 2007
    Publication date: March 18, 2010
    Inventors: Yun Ding, Joseph Paul Marino, Peng Li, Allyn T. Londregan, Barry A. Morgan
  • Imidazolyl derivatives
    Patent number: 7638546
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: December 29, 2009
    Assignee: IPSEN Pharma S.A.S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Thomas D. Gordon, Barry A. Morgan, Christophe Philippe Moinet, Dennis C. H. Bigg
  • Imidazolyl derivatives
    Patent number: 7566734
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: July 28, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Thomas D. Gordon, Barry A. Morgan, Christophe Philippe Moinet, Dennis C. H. Bigg
  • Farnesyl transferase inhibitors
    Patent number: 7553975
    Abstract: A family of compounds capable of inhibiting the activity of farnesyl transferase.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: June 30, 2009
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Prenyl Transferase Inhibitors
    Publication number: 20080176835
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 24, 2008
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Neuromedin B and somatostatin receptor agonists
    Publication number: 20080132453
    Abstract: A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostatin receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH2.
    Type: Application
    Filed: April 11, 2005
    Publication date: June 5, 2008
    Inventors: Barry A. Morgan, Dean Sadat-Aalaee
  • Prenyl transferase inhibitors
    Patent number: 7361656
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: April 22, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Farnesyl transferase inhibitors
    Patent number: 7323484
    Abstract: The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumors and restenosis.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: January 29, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Imidazolyl derivatives
    Patent number: 7238695
    Abstract: The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wherein the substituents are defined in the specification.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: July 3, 2007
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Christophe Philippe Moinet, Thomas D. Gordon, Barry A. Morgan
  • Somatostatin agonists
    Patent number: 7144859
    Abstract: The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatostatin subtype receptor type-5 and elicit an agonist effect from the somatostatin subtype receptors.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: December 5, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques SAS
    Inventors: Dean Sadat-Aalaee, Barry A. Morgan
  • Somatostatin analog and uses thereof
    Patent number: 7094753
    Abstract: Claimed is a somatostatin agonist according to formula (I), D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2, ??(I) or a pharmaceutically acceptable salt thereof, and uses thereof.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 22, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Thomas D. Gordon, Barry A. Morgan, Michael D. Culler
  • Prenyl transferase inhibitors
    Patent number: 7084135
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: August 1, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Farnesyl transferase inhibitors
    Patent number: 7022704
    Abstract: A family of tetrahydroimidazo[1,2a]pyrazine based compounds capable of inhibiting the activity of farnesyl transferase and treating tumors and restenosis having the following structure: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: April 4, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Neuromedin b and somatostatin receptor agonists
    Patent number: 6903074
    Abstract: A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostann receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH2.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: June 7, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Barry A. Morgan, Dean Sadat-Aalaee
  • Somatostatin agonists
    Patent number: 6864234
    Abstract: The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatostatin subtype receptor type-5 and elicit an agonist effect from the somatostatin subtype receptors.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: March 8, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Dean Sadat-Aalaee, Barry A. Morgan
  • Imidazolyl derivatives
    Patent number: 6852725
    Abstract: The present invention is directed to imidazolyl derivatives of the formula: where the substituents are defined in the specification, or a pharmaceutically acceptable salt thereof. The derivatives bind selectively to the somatostatin subtype receptors and elicit either an agonist or antagonist effect from the somatostatin subtype receptors.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: February 8, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S. A. S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Christophe Philippe Moinet, Thomas D. Gordon, Barry A. Morgan
  • Imidazolyl derivatives
    Publication number: 20040176379
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
    Type: Application
    Filed: February 4, 2004
    Publication date: September 9, 2004
    Inventors: Christopher Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Christophe Philippe Moinet, Thomas D. Gordon, Barry A. Morgan