Patents by Inventor Barry A. Morgan

Barry A. Morgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Somatostatin antagonists
    Patent number: 7550423
    Abstract: The invention features somatostatin antagonists having a D-amino acid at the second residue.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 23, 2009
    Assignees: The Administrators of the Tulane Educational Fund, Societe de Conseils de Recherches et d'Applications Squentifiques, S.A.S.
    Inventors: David H. Coy, Barry Morgan, William Murphy
  • Methionine aminopeptidase-2 inhibitors and methods of use thereof
    Publication number: 20090156624
    Abstract: The present invention provides methods of parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
    Type: Application
    Filed: January 29, 2008
    Publication date: June 18, 2009
    Applicant: Praecis Pharmaceuticals Inc
    Inventors: Gary L. Olson, Christopher Self, Lily Lee, Charles Michael Cook, Jens Birktoft, Barry Morgan, Christopher C. Arico-Muendel
  • Methods for synthesis of encoded libraries
    Publication number: 20090062147
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: October 4, 2007
    Publication date: March 5, 2009
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Therapeutic agents and methods of use thereof for the treatment of melanoma
    Patent number: 7405194
    Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: July 29, 2008
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Gary L. Olson, Christopher Self, Lily Lee, Charles M. Cook, Jens Birktoft, Barry Morgan, Christopher C. Arico-Muendel
  • Prenyl Transferase Inhibitors
    Publication number: 20080176835
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 24, 2008
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Neuromedin B and somatostatin receptor agonists
    Publication number: 20080132453
    Abstract: A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostatin receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH2.
    Type: Application
    Filed: April 11, 2005
    Publication date: June 5, 2008
    Inventors: Barry A. Morgan, Dean Sadat-Aalaee
  • Prenyl transferase inhibitors
    Patent number: 7361656
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: April 22, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Methionine aminopeptidase-2 inhibitors and methods of use thereof
    Patent number: 7348307
    Abstract: The present invention provides methods of treating a lymphoma (e.g.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: March 25, 2008
    Assignee: Praecis Pharmaceuticals Incorporated
    Inventors: Gary L. Olson, Christopher Self, Lily Lee, Charles M. Cook, Jens Birktoft, Barry Morgan, Christopher C. Arico-Muendel
  • Methods and compositions for modulating sphingosine -1- phosphate (S1P) receptor activity
    Publication number: 20080064662
    Abstract: The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: May 22, 2007
    Publication date: March 13, 2008
    Applicant: Praecis Pharmaceuticals incorporated
    Inventors: Ashis Saha, Malcolm Kavarana, Ghotas Evindar, Alexander Satz, Barry Morgan
  • Farnesyl transferase inhibitors
    Patent number: 7323484
    Abstract: The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumors and restenosis.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: January 29, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Imidazolyl derivatives
    Publication number: 20070299073
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors.
    Type: Application
    Filed: May 22, 2007
    Publication date: December 27, 2007
    Inventors: Christophe Thurieau, Lydie Poitout, Marie-Odile Galcera, Thomas Gordon, Barry Morgan, Christophe Moinet
  • System for Determining the Displacement of a Movable Member
    Publication number: 20070256507
    Abstract: A means for simultaneous determination of the radial and angular vectors of rotary motion of a body relative to a single reference axis, by measurement of the common aid differential states of three position detectors and, together with an axial position detector, thus to allow the measurable modulation of magnetic devices such as to provide measurable vector forces to support that body against the vector effects of any external forces that tend to change its position relative to the reference axis, in the absence of any contact between the rotor and the combined system of sensors and magnetic devices.
    Type: Application
    Filed: August 26, 2005
    Publication date: November 8, 2007
    Inventor: Barry Morgan
  • Methods for identifying compounds of interest using encoded libraries
    Publication number: 20070224607
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: October 23, 2006
    Publication date: September 27, 2007
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry Morgan, Stephen Hale, Christopher Arico-Muendel, Matthew Clark, Richard Wagner, David Israel, Malcolm Gefter, Dennis Benjamin, Nils Hansen, Malcolm Kavarana, Steffen Creaser, George Franklin, Paolo Centrella, Raksha Acharya
  • Methionine aminopeptidase-2 inhibitors and methods of use thereof
    Publication number: 20070161570
    Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of inducing an immunosupressed condition and/or treating chronic allograft vasculopathy in a subject undergoing or who has undergone a transplant, by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
    Type: Application
    Filed: July 21, 2006
    Publication date: July 12, 2007
    Applicant: Praecis Pharmaceuticals, Inc.
    Inventors: Gary Olson, Christopher Self, Lily Lee, Charles Cook, Jens Birktoft, Barry Morgan, Christopher Arico-Muendel
  • Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
    Patent number: 7241812
    Abstract: The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: July 10, 2007
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Ashis K. Saha, Malcolm J. Kavarana, Ghotas Evindar, Alexander L. Satz, Barry Morgan
  • Imidazolyl derivatives
    Patent number: 7238695
    Abstract: The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wherein the substituents are defined in the specification.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: July 3, 2007
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Christophe Philippe Moinet, Thomas D. Gordon, Barry A. Morgan
  • Therapeutic agents and methods of use thereof for the modulation of angiogenesis
    Publication number: 20070117758
    Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
    Type: Application
    Filed: November 7, 2006
    Publication date: May 24, 2007
    Applicant: Praecis Pharmaceuticals, Inc.
    Inventors: Gary Olson, Christopher Self, Lily Lee, Charles Cook, Jens Birktoft, Barry Morgan, Christopher Arico-Muendel
  • Methods for synthesis of encoded libraries
    Publication number: 20070042401
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: June 9, 2006
    Publication date: February 22, 2007
    Applicant: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher Arico-Muendel, Matthew Clark, Richard Wagner, David Israel, Malcolm Gefter, Dennis Benjamin, Nils Hansen, Malcolm Kavarana, Steffen Creaser, George Franklin, Paolo Centrella, Raksha Acharya
  • Imidazolyl derivatives
    Publication number: 20070032653
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
    Type: Application
    Filed: July 31, 2001
    Publication date: February 8, 2007
    Inventors: Christophe Thurieau, Lydie Poitout, Marie-Odile Galcera, Thomas Gordon, Barry Morgan, Christopher Moinet, Dennis Bigg
  • Methionine aminopeptidase-2 inhibitors and methods of use thereof
    Publication number: 20070010452
    Abstract: The present invention provides methods of parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
    Type: Application
    Filed: May 3, 2006
    Publication date: January 11, 2007
    Applicant: Praecis Pharmaceuticals, Inc.
    Inventors: Gary Olson, Christopher Self, Lily Lee, Charles Cook, Jens Birktoft, Barry Morgan, Christopher Arico-Muendel