Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Systems include a plurality of sensors coupled to a person support apparatus, at least one moisture sensor configured to sense a moisture level between the person and the support surface, and at least one computing device coupled to the plurality of sensors coupled to the person support apparatus and the at least one moisture sensor. The at least one computing device receives data from the plurality of sensors coupled to the person support apparatus and the at least one moisture sensor, obtains data from an electronic medical record associated with the person supported by the person support apparatus, calculates a pressure injury score indicative of a likelihood that the person will develop a pressure injury based on the data from the plurality of sensors, the at least one moisture sensor, and the electronic medical record, and alters a treatment plan for the person based on the calculated pressure injury score.

Abstract: An internal core profile for a turbine nozzle airfoil of a gas turbine is provided. The turbine nozzle may include an airfoil core having an uncoated nominal profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, wherein the X, Y, and Z coordinates are distances in inches measured in a Cartesian coordinate system, the corresponding X and Y coordinates, when connected by a smooth continuous arc, define one of a plurality of airfoil core profile sections at each Z distance, and the plurality of airfoil core profile sections, when joined together by smooth continuous arcs, define an airfoil core shape.

Abstract: An internal core profile for a turbine nozzle airfoil of a gas turbine is provided. The turbine nozzle may include an airfoil core having an uncoated nominal profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, wherein the X, Y, and Z coordinates are distances in inches measured in a Cartesian coordinate system, the corresponding X and Y coordinates, when connected by a smooth continuous arc, define one of a plurality of airfoil core profile sections at each Z distance, and the plurality of airfoil core profile sections, when joined together by smooth continuous arcs, define an airfoil core shape.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: An airfoil profile for a turbine blade of a gas turbine is provided. The turbine blade may include an airfoil portion having an uncoated nominal profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, wherein the X, Y, and Z coordinates are distances in inches measured in a Cartesian coordinate system, the corresponding X and Y coordinates, when connected by a smooth continuous arc, define one of a plurality of airfoil profile sections at each Z distance, and the plurality of airfoil profile sections, when joined together by smooth continuous arcs, define an airfoil shape.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: An internal core profile for a second stage turbine nozzle airfoil of a gas turbine is provided. The turbine nozzle may include an airfoil core having an uncoated nominal profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, wherein the X, Y, and Z coordinates are distances in inches measured in a Cartesian coordinate system, the corresponding X and Y coordinates, when connected by a smooth continuous arc, define one of a plurality of airfoil core profile sections at each Z distance, and the plurality of airfoil core profile sections, when joined together by smooth continuous arcs, define an airfoil core shape.

Abstract: An airfoil profile for a turbine blade of a gas turbine is provided. The turbine blade may include an airfoil portion having an uncoated nominal profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, wherein the X, Y, and Z coordinates are distances in inches measured in a Cartesian coordinate system, the corresponding X and Y coordinates, when connected by a smooth continuous arc, define one of a plurality of airfoil profile sections at each Z distance, and the plurality of airfoil profile sections, when joined together by smooth continuous arcs, define an airfoil shape.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: There is described a topical composition for application of an NSAID comprising ibuprofen, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an ester of a higher fatty acid and optionally water, the ingredients of the residual carrier system having the following concentrations in percentages by weight: polyhydric alcohol 50-90 glycol ether 7.5-40 ester 0.5-5 water optional in which either the composition or the residual phase is in a single phase under ambient conditions and the maximum water concentration is that above which the composition or the residual phase exhibits signs of inhomogeneity.

Abstract: The present disclosure provides methods, computer readable media, and a system comprising: a hierarchical data storage architecture comprising the following storage tiers: a first tier configured to store a data element associated with a first range of recall probability scores, and a second tier configured to store a data element associated with a second range of recall probability scores; a computing agent configured to perform the following: compute a recall probability score for the data element stored in the hierarchical data storage architecture, and affect a transfer of the data element between the first and second tier; and a graphical user interface (GUI) comprising at least one functional GUI element configured to: enable an end-user to input a desired balance between speed of data retrieval and cost of data storage, wherein the desired balance impacts the plurality of ranges of recall probability scores associated with the first and second tier.

Abstract: The present disclosure provides methods, computer readable media, and a system comprising: a hierarchical data storage architecture comprising the following storage tiers: a first tier configured to store a data element associated with a first range of recall probability scores, and a second tier configured to store a data element associated with a second range of recall probability scores; a computing agent configured to perform the following: compute a recall probability score for the data element stored in the hierarchical data storage architecture, and affect a transfer of the data element between the first and second tier; and a graphical user interface (GUI) comprising at least one functional GUI element configured to: enable an end-user to input a desired balance between speed of data retrieval and cost of data storage, wherein the desired balance impacts the plurality of ranges of recall probability scores associated with the first and second tier.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Cards may be manufactured in a lamination process, such that interior portions of the cards may be visible. Punch alignment queues within the card may be scanned by a punch machine and rendered onto a display of the punch machine. The punch alignment queues may be aligned with targets also rendered onto the display so that the card may be properly aligned within a punch machine to prepare the card for a trimming process. A Venturi system may temporarily adhere the card to a punch of the punch machine while the punch is engaged with a die to trim the card. The cutting surface of the die may be offset with respect to a surface of the punch, so that the card may be sequentially trimmed along a perimeter of the card.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.