Abstract: The present disclosure provides methods, computer readable media, and a system (the “platform”) for recall probability-based data storage and retrieval. The platform may comprise a hierarchical data storage architecture having at least one of the following storage tiers: a first tier, and a second tier; at least one computing agent, wherein the at least one computing agent is configured to: compute a recall probability for a data element stored in the data storage, and effect a transfer of the data element based on, at least in part, the recall probability, wherein the transfer of the data element is between at least the following: the first tier, and the second tier; and a graphical user interface (GUI) comprising at least one functional GUI element configured to: enable an end-user to specific a desired balance between at least one of the following elements: speed of data retrieval, and cost of data storage.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: Embodiments of topical formulations for administering cerdulatinib or a pharmaceutically acceptable salt, hydrate or solvate thereof are disclosed. Embodiments of methods for preparing the topical formulations are also disclosed. The disclosed formulations are suitable for the treatment of dermatologic conditions such as atopic dermatitis.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.

Abstract: Disclosed herein are compositions and methods for topical delivery of mTOR inhibitors. In one embodiment, an anhydrous composition includes one or more mTOR inhibitors, one or more solvents, one or more gelling agents, and one or more antioxidants. Also disclosed herein are methods to treat skin disorders using such compositions.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: Systems include a plurality of sensors coupled to a person support apparatus, at least one moisture sensor configured to sense a moisture level between the person and the support surface, and at least one computing device coupled to the plurality of sensors coupled to the person support apparatus and the at least one moisture sensor. The at least one computing device receives data from the plurality of sensors coupled to the person support apparatus and the at least one moisture sensor, obtains data from an electronic medical record associated with the person supported by the person support apparatus, calculates a pressure injury score indicative of a likelihood that the person will develop a pressure injury based on the data from the plurality of sensors, the at least one moisture sensor, and the electronic medical record, and alters a treatment plan for the person based on the calculated pressure injury score.

Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.

Abstract: One embodiment may include a method of converting an electronic device into a tracking device that is part of a system of tracking devices distributed throughout a geographic area to track signal emitting devices travelling through the geographic area. The method may include providing an electronic device, the electronic device positioned in the geographic area; communicatively coupling a converter with the electronic device, wherein the converter has a memory device with location tracking software stored thereon; and uploading the tracking software from the converter to the electronic device so as to convert the electronic device into a converted tracking device having the tracking software, wherein the converted tracking device becomes part of the system of tracking devices distributed throughout the geographic area to track the signal emitting devices travelling through the geographic area.

Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.

Abstract: There is provided the use of compounds of formula I wherein R1, R2, R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula I per se.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: There is described a topical composition for application of an NSAID comprising ibuprofen, the composition comprising a solution or suspension of the NSAID as active ingredient in a residual carrier system comprising a polyhydric alcohol, a glycol ether, an ester of a higher fatty acid and optionally water, the ingredients of the residual carrier system having the following concentrations in percentages by weight: polyhydric alcohol 50-90 glycol ether 7.5-40 ester 0.5-5 water optional in which either the composition or the residual phase is in a single phase under ambient conditions and the maximum water concentration is that above which the composition or the residual phase exhibits signs of inhomogeneity.

Abstract: One embodiment may include a method of converting an electronic device into a tracking device that is part of a system of tracking devices distributed throughout a geographic area to track signal emitting devices travelling through the geographic area. The method may include providing an electronic device, the electronic device positioned in the geographic area; communicatively coupling a converter with the electronic device, wherein the converter has a memory device with location tracking software stored thereon; and uploading the tracking software from the converter to the electronic device so as to convert the electronic device into a converted tracking device having the tracking software, wherein the converted tracking device becomes part of the system of tracking devices distributed throughout the geographic area to track the signal emitting devices travelling through the geographic area.

Abstract: Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.

Abstract: One embodiment may include a method of converting an electronic device into a tracking device that is part of a system of tracking devices distributed throughout a geographic area to track signal emitting devices travelling through the geographic area. The method may include providing an electronic device, the electronic device positioned in the geographic area; communicatively coupling a converter with the electronic device, wherein the converter has a memory device with location tracking software stored thereon; and uploading the tracking software from the converter to the electronic device so as to convert the electronic device into a converted tracking device having the tracking software, wherein the converted tracking device becomes part of the system of tracking devices distributed throughout the geographic area to track the signal emitting devices travelling through the geographic area.

Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.