Patents by Inventor Barry Hart

Barry Hart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERNAL COMBUSTION ENGINE OPTIMISATION SYSTEM AND METHOD
    Publication number: 20230296061
    Abstract: The present invention relates to internal combustion engines. More particularly, the present invention relates to an arrangement whereby internal combustion engines can be operated more efficiently at higher compression pressures. Aspects and/or embodiments seek to provide a method and/or apparatus and/or system for using very high compression ratios in internal combustion engines while preventing damage from pinking or knocking.
    Type: Application
    Filed: August 9, 2021
    Publication date: September 21, 2023
    Inventor: Barry Hart
  • Drug compounding skid and compounding method
    Patent number: 9314404
    Abstract: A drug compounding skid for sterile transfer of a compounded drug. The skid includes vessels configured to form a sterile seal of a drug contained therein. The skid may include a sterilization system, a drug transfer system, and a cleaning system. The skid may be used to perform sterile transfer of a compounded drug from the vessels to a holding tank. A skid may include a plurality of drug compounding tanks with agitation devices mounted thereto.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: April 19, 2016
    Assignee: Allergan, Inc.
    Inventors: Jose Gonzalez-Miranda, Brad Borgwald, Thomas Buckley, Barry Hart
  • NOVEL MEK INHIBITORS FOR TREATING CARDIOMYOPATHIES AND RELATED CONDITIONS
    Publication number: 20150250762
    Abstract: The invention pertains to compound of Formula (I) wherein X, Y, Z, R1, R2, R3, R4, A, and A? are described herein. Formula (I) compounds can be used in pharmaceutical compositions, useful for the treatment of disease, in particular cardiovascular conditions and more particularly cardiomyopathies, as well as other related conditions.
    Type: Application
    Filed: April 10, 2015
    Publication date: September 10, 2015
    Inventors: Howard J. Worman, Antoine Muchir, Uday R. Khire, Mahendra Devichand Chordia, Barry Hart
  • DRUG COMPOUNDING SKID AND COMPOUNDING METHOD
    Publication number: 20140209727
    Abstract: A drug compounding skid for sterile transfer of a compounded drug. The skid includes vessels configured to form a sterile seal of a drug contained therein. The skid may include a sterilization system, a drug transfer system, and a cleaning system. The skid may be used to perform sterile transfer of a compounded drug from the vessels to a holding tank. A skid may include a plurality of drug compounding tanks with agitation devices mounted thereto.
    Type: Application
    Filed: March 21, 2013
    Publication date: July 31, 2014
    Inventors: Jose Gonzalez-Miranda, Brad Borgwald, Thomas Buckley, Barry Hart
  • Process for the preparation of ()-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof
    Patent number: 8324417
    Abstract: The present invention relates to a process for the preparation of alkyl esters of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)—N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: December 4, 2012
    Assignee: ViroBay, Inc.
    Inventors: Barry Hart, Jeff Dener, Michael Green, Michael Standen, Oldrich Kocian
  • PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF
    Publication number: 20110046406
    Abstract: The present invention relates to a process for the preparation of alkyl esters of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)-N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-(S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors.
    Type: Application
    Filed: August 16, 2010
    Publication date: February 24, 2011
    Applicant: ViroBay, Inc.
    Inventors: Barry Hart, Jeff Dener, Michael Green, Michael Standen, Oldrich Kocian
  • RHO-KINASE INHIBITORS
    Publication number: 20100216789
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: January 15, 2010
    Publication date: August 26, 2010
    Inventors: Dhanapalan NAGARATHNAM, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
  • RHO-KINASE INHIBITORS
    Publication number: 20100137324
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: February 2, 2010
    Publication date: June 3, 2010
    Inventors: Dhanaphalan Nagarathnam, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Uday Khire, Chunguang Wang, Barry Hart, Stephen Boyer, Olaf Weber, Mark Lynch
  • PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF
    Publication number: 20100125139
    Abstract: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
    Type: Application
    Filed: November 17, 2009
    Publication date: May 20, 2010
    Inventors: Donald BANKSTON, Dhanaphalan Nagarathnam, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Uday Khire, Chunguang Wang, Barry Hart, Stephen Boyer, Olaf Weber, Mark Lynch
  • Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
    Patent number: 7648986
    Abstract: Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: January 19, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
  • Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
    Patent number: 7645878
    Abstract: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: January 12, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Donald Bankston, Dhanaphalan Nagarathnam, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Uday Khire, Chunguang Wang, Barry Hart, Stephen Boyer, Olaf Weber, Mark Lynch
  • ANTIVIRAL AGENTS
    Publication number: 20070287699
    Abstract: Compounds are provided having utility for the treatment of viral infections, particularly HCV.
    Type: Application
    Filed: April 30, 2007
    Publication date: December 13, 2007
    Applicant: ViroBay, Inc.
    Inventors: Dange Kumar, Roopa Rai, Wendy Young, Huiyong Hu, Jennifer Riggs, Tony Ton, Michael Green, Barry Hart, Kenneth Brameld, Jeffrey Dener
  • RHO-KINASE INHIBITORS
    Publication number: 20070238741
    Abstract: Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 11, 2007
    Inventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
  • Fused bicyclic inhibitors of TGFbeta
    Publication number: 20070066632
    Abstract: Certain appropriately substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with excessive TGF? activity and certain viral disorders.
    Type: Application
    Filed: March 27, 2006
    Publication date: March 22, 2007
    Applicant: Scios, Inc.
    Inventors: Barry Hart, Sarvajit Chakravarty, Jonathan Axon, Alison Murphy, Glenn McEnroe
  • Carboxamide inhibitors of TGFbeta
    Publication number: 20060281763
    Abstract: Certain appropriately substituted forms of pyrimidine having a pyridylamine group at C-4 of the pyrimidine and an amide group on the pyridine ring are useful in the treatment of conditions associated with excessive TGF? activity.
    Type: Application
    Filed: March 27, 2006
    Publication date: December 14, 2006
    Inventors: Jonathan Axon, Sarvajit Chakravarty, Barry Hart, Glenn McEnroe, Alison Murphy, Karen Pontius, Peijue Sheng, Xiaojing Wang, Shanthi Yellapregada
  • Rho-kinase inhibitors
    Publication number: 20060142313
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: February 16, 2006
    Publication date: June 29, 2006
    Inventors: Dhanaphalan Nagarathnam, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Uday Khire, Chunguang Wang, Barry Hart, Stephen Boyer, Olaf Weber, Mark Lynch
  • 4-AMINO-5,6-SUBSTITUTED THIOPHENO [2,3-D] PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND THEIR USE IN THE TREATMENT OR PREVENTION OF PDE7B-MEDIATED DISEASES AND CONDITIONS
    Patent number: 6849638
    Abstract: The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B (PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: February 1, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Andreas Stolle, Donald E. Bierer, Yuanwei Chen, Dongping Fan, Barry Hart, Mary Katherine Monahan, William J. Scott
  • Substituted 3-pyridyl imidazoles as c17,20 lyase inhibitors
    Publication number: 20040209924
    Abstract: This invention provides 3-pyridyl imidazoles, pharmaceutical compositions containing them, and methods of using these for treatment of cancer.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 21, 2004
    Inventors: Barry Hart, Donald E Bierer, Jacques Dumas, Robert Sibley, Chengzhi Zhang
  • Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors
    Publication number: 20040198773
    Abstract: Substituted 3-pyridyl oxazoles which inhibit C17, 20 Lyase, pharmaceutical preparations containing them, and methods of using them in treatment of cancer arc provided.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 7, 2004
    Inventors: Barry Hart, Donald E Bierer, Chengzhi Zhang
  • Rho-kinase inhibitors
    Publication number: 20040014755
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: January 10, 2003
    Publication date: January 22, 2004
    Inventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang