Abstract: Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.

Abstract: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

Abstract: Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.

Abstract: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The assemblies include carriers and sample processing devices with process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas. The carriers may be used to apply selective compression to the sample processing devices.

Abstract: Devices, methods, and systems for processing sample materials are disclosed. The present invention may provide a bridge between standard microtiter plate systems, methods, protocols, etc. (that include wells arranged in rectangular arrays) and rotating sample processing devices and systems that allow users to obtain the rapid processing advantages of the more advanced sample processing devices. The sample processing devices preferably include a rectangular body to improve compatibility of the sample processing devices of the present invention with equipment designed for use with more conventional microtiter plates (which are typically rectangular in shape). The sample processing devices also include at least one set of process chambers arranged in one or more circular arcs and may include input and/or output chambers arranged in a rectilinear grid array.

Abstract: A cartridge for use in a stapler for driving staples during orthopedic surgery is described. The cartridge has a case comprising a first wall and side walls projecting from this first wall. The cartridge has inner guide surfaces intended to guide the movement of staples when they are ejected by the stapler, and these preferably include the top of extended projections from a spacer element which is snap fit to the case. Within the case are a stack of staples supported on a follower which pushes on the side of the stack of staples so as to sequentially present each one in turn in a position to be ejected by the stapler. The follower is centered and slidably mounted on a guidepost which helps the follower resist any tendency for misalignment of the follower within the case.

Abstract: A cartridge for use in a stapler for driving staples during orthopedic surgery is described. The cartridge has a case comprising a first wall and side walls projecting from this first wall. The cartridge has inner guide surfaces intended to guide the movement of staples when they are ejected by the stapler, and these preferably include the top of extended projections from a spacer element which is snap fit to the case. Within the case are a stack of staples supported on a follower which pushes on the side of the stack of staples so as to sequentially present each one in turn in a position to be ejected by the stapler. The follower is centered and slidably mounted on a guidepost which helps the follower resist any tendency for misalignment of the follower within the case.