Patents by Inventor Barry Wilkinson

Barry Wilkinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110027185
    Abstract: The present invention relates to methods of screening for agents that bind to FBP21. In particular the present invention provides a method of identifying anti-angiogenic agents by screening for agents which are able to bind to FBP21. Compounds identified using the methods and screens of the present invention are useful in the prevention and treatment of conditions associated with angiogenesis.
    Type: Application
    Filed: July 14, 2008
    Publication date: February 3, 2011
    Inventors: Barrie Wilkinson, Christine Martin, William Vousden, Steven Moss
  • Publication number: 20100279995
    Abstract: There are provided inter alia derivatives of a benzenoid ansamycin which contain a 1,4-dihydroxyphenyl moiety bearing at position 6 an amino carboxy substituent, in which position 2 and the carboxy substituent at position 6 are connected by an aliphatic chain of varying length characterised in that one or both of the 1-hydroxy and the 4-hydroxy position(s) of the phenyl ring are independently derivatised by an aminoalkyleneaminocarbonyl group, which alkylene group, which may optionally be substituted by alkyl groups, has a chain length of 2 or 3 carbons and which derivatising group(s) increase the water solubility and/or the bioavailability of the parent molecule but which are capable of being removed in-vivo. Such compounds are described for the treatment of cancer or B-cell malignancies.
    Type: Application
    Filed: September 1, 2006
    Publication date: November 4, 2010
    Inventors: Alexander R. Guiblin, Barrie Wilkinson, Steven J. Moss, Ming-Qiang Zhang, Alison D. McElhinney, Christine J. Martin
  • Publication number: 20100081682
    Abstract: The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
    Type: Application
    Filed: December 3, 2009
    Publication date: April 1, 2010
    Applicant: Biotica Technology Limited
    Inventors: Christoph Hendrik Beckmann, Steven James Moss, Rose Mary Sheridan, Mingqiang Zhang, Barrie Wilkinson
  • Publication number: 20100068785
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: November 11, 2009
    Publication date: March 18, 2010
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • Patent number: 7648996
    Abstract: The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: January 19, 2010
    Assignee: Biotica Technology Limited
    Inventors: Christoph Hendrik Beckmann, Steven James Moss, Rose Mary Sheridan, Mingqiang Zhang, Barrie Wilkinson
  • Publication number: 20090312316
    Abstract: The present invention relates to derivatives of borrelidin that are useful in medicine, e.g. in the treatment of cancer or B-cell malignancies, or other diseases in which angiogenesis contributes to the pathology including ophthalmic disorders such as diabetic retinopathy as well as age related macular degeneration (AMD), corneal neovascularisation and retinopathy or prematurity. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies and other diseases in which angiogenesis is implicated in the pathogenic process.
    Type: Application
    Filed: May 17, 2007
    Publication date: December 17, 2009
    Inventors: Barrie Wilkinson, Steven Moss, Ming Zhang
  • Publication number: 20090298804
    Abstract: The present invention relates to 15-desmethoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: December 3, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Nigel Coates, Mohammed Nur-E-Alam, Nikolaos Galtatzis
  • Patent number: 7626010
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: December 1, 2009
    Assignee: Dow AgroSciences LLC
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • Publication number: 20090286291
    Abstract: The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and Methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of polyketides including borrelidin and analogues and derivatives thereof. Novel polyketide molecules are also provided.
    Type: Application
    Filed: June 9, 2009
    Publication date: November 19, 2009
    Inventors: Jose A. Salas, Carmen Mendez, Carlos Olano, Cesar Sanchez, Alfredo F. Brana, Barrie Wilkinson, Christine J. Martin, Steven Moss, Peter F. Leadlay, Marko Oliynyk
  • Publication number: 20090209507
    Abstract: The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: August 20, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Nigel Coates, Mohammed Nur-E-Alam, William Vousden
  • Publication number: 20090209572
    Abstract: The present invention relates to novel 36-des(3-methoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyl)rapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 36-des(3-methoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyl)rapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
    Type: Application
    Filed: November 19, 2008
    Publication date: August 20, 2009
    Applicant: Biotica Technology Limited
    Inventors: Barrie Wilkinson, Ming-Qiang Zhang, Rose Mary Sheridan, Christoph Beckmann
  • Publication number: 20090209494
    Abstract: The present invention relates to 21-deoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 20, 2009
    Inventors: Christine Janet Martin, Barrie Wilkinson, Sabine Gaisser, Ming-Oiang Zhang, Rose Mary Sheridan, Lesley Sarah Sheehan, Rachel Edith Lill, Mohammed Nur-E-Alam, William Alexander Vousden
  • Patent number: 7560252
    Abstract: The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of polyketides including borrelidin and analogues and derivatives thereof. Novel polyketide molecules are also provided.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: July 14, 2009
    Assignees: Biotica Technology Limited, The University of Oviedo
    Inventors: Jose A Salas, Carmen Mendez, Carlos Olano, Cesar Sanchez, Alfredo F Brana, Barrie Wilkinson, Christine J Martin, Steven Moss, Peter F Leadlay, Marko Oliynyk
  • Publication number: 20090176819
    Abstract: The present invention relates to novel 39-desmethoxy-39-methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy-39-methylrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
    Type: Application
    Filed: November 19, 2008
    Publication date: July 9, 2009
    Applicants: Wyeth, Biotica Technology Limited
    Inventors: Barrie Wilkinson, Ming-Qiang Zhang, Rose Mary Sheridan
  • Publication number: 20090117127
    Abstract: The present invention relates to 11-O-desmethylmacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 7, 2009
    Inventors: Sabine Gaisser, Christine Martin, Ming Zhang, Barrie Wilkinson, Lesley Sheehan, Nigel Coates, Mohammed Nur-E-Alam, William Vousden, Nikolaos Gaitatzis
  • Publication number: 20080188511
    Abstract: The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
    Type: Application
    Filed: March 10, 2006
    Publication date: August 7, 2008
    Inventors: Christoph Hendrik Beckmann, Steven James Moss, Rose Mary Sheridan, Mingqiang Zhang, Barrie Wilkinson
  • Publication number: 20060040877
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 23, 2006
    Inventors: Lesley Burns, Paul Graupner, Paul Lewer, Christine Martin, William Vousden, Clive Waldron, Barrie Wilkinson
  • Publication number: 20030225006
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: February 19, 2003
    Publication date: December 4, 2003
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson