Patents by Inventor Bassil I. Dahiyat

Bassil I. Dahiyat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TNF-? variants
    Patent number: 7056695
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 6, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Apparatus and method for automated protein design
    Patent number: 6950754
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: September 27, 2005
    Assignee: The California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Nucleic acids and proteins with growth hormone activity
    Patent number: 6946265
    Abstract: The invention relates to novel growth hormone activity (GHA) proteins and nucleic acids. The invention further relates to the use of the GHA proteins in the treatment of growth hormone related disorders.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: September 20, 2005
    Assignee: Xencor, Inc.
    Inventors: Anton Filikov, Bassil I. Dahiyat
  • Novel proteins with altered immunogenicity
    Publication number: 20040230380
    Abstract: The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.
    Type: Application
    Filed: January 8, 2004
    Publication date: November 18, 2004
    Applicant: Xencor
    Inventors: Arthur J. Chirino, Bassil I. Dahiyat, John Rudolph Desjarlais, Shannon Alicia Marshall
  • Apparatus and method for automated protein design
    Patent number: 6804611
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 12, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Apparatus and method for automated protein design
    Patent number: 6801861
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: October 5, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Apparatus and method for automated protein design
    Patent number: 6792356
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: September 14, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Dominant negative proteins and methods thereof
    Publication number: 20040170602
    Abstract: The invention relates to novel proteins with TNFSF antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNFSF-related disorders.
    Type: Application
    Filed: July 1, 2003
    Publication date: September 2, 2004
    Inventors: John R. Desjarlais, Malu Lourdes G. Tansey, Bassil I. Dahiyat
  • Antibody optimization
    Publication number: 20040110226
    Abstract: The present invention relates to the use of computational screening methods to optimize the physico-chemical properties of antibodies, including stability, solubility, and antigen binding affinity.
    Type: Application
    Filed: March 3, 2003
    Publication date: June 10, 2004
    Applicant: Xencor
    Inventors: Gregory Alan Lazar, John Rudolf Desjarlais, Shannon Alicia Marshall, Bassil I. Dahiyat
  • Proteins with insulin-like activity useful in the treatment of diabetes
    Patent number: 6746853
    Abstract: The invention relates to novel insulin activity (IA) proteins and nucleic acids. The Invention further relates to the use of the IA proteins in the treatment of insulin related disorders such as type 1 diabetes and type 2 diabetes.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 8, 2004
    Assignee: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Andrew G. Morton
  • Nucleic acids and protein variants of hG-CSF with granulopoietic activity
    Publication number: 20040096945
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Application
    Filed: August 1, 2003
    Publication date: May 20, 2004
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Apparatus and method for automated protein design
    Patent number: 6708120
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 16, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Protein design automation for protein libraries
    Publication number: 20040043430
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: September 18, 2003
    Publication date: March 4, 2004
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Joerg Bentzien, Klaus M. Fiebig
  • Protein design automation for protein libraries
    Publication number: 20040043429
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: September 18, 2003
    Publication date: March 4, 2004
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Joerg Bentzien, Klaus M. Fiebig
  • Thermostable alkaliphilic xylanase
    Patent number: 6682923
    Abstract: The invention relates to novel xylanase activity (XA) proteins and nucleic acids. The invention further relates to the use of the XA proteins in the process of pulp bleaching.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 27, 2004
    Assignee: Xencor
    Inventors: Jörg Bentzien, Bassil I. Dahiyat
  • Nucleic acids and protein variants of hG-CSF with granulopoietic activity
    Patent number: 6627186
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: September 30, 2003
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Dominant negative proteins and methods thereof
    Publication number: 20030166559
    Abstract: The invention relates to novel proteins with TNFSF antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNFSF-related disorders.
    Type: Application
    Filed: January 6, 2003
    Publication date: September 4, 2003
    Inventors: John R. Desjarlais, Malu Lourdes G. Tansey, Bassil I. Dahiyat
  • Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
    Publication number: 20030138401
    Abstract: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
    Type: Application
    Filed: September 30, 2002
    Publication date: July 24, 2003
    Inventors: Bassil I. Dahiyat, John R. Desjarlais, Anton Filikov, Umesh Muchhal, Malu Lourdes G. Tansey, Jonathan Zalevsky
  • Protein design automation for protein libraries
    Publication number: 20030130827
    Abstract: The invention relates to the use of protein design automation (PDA™) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: August 12, 2002
    Publication date: July 10, 2003
    Inventors: Joerg Bentzien, Bassil I. Dahiyat, John R. Desjarlais, Robert J. Hayes, Jost Vielmetter
  • Protein design automation for protein libraries
    Publication number: 20030049654
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: March 18, 2002
    Publication date: March 13, 2003
    Applicant: XENCOR
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Jorg Bentzien, Klaus M. Fiebig