Patents by Inventor Bassil I. Dahiyat

Bassil I. Dahiyat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein design automation for designing protein libraries with altered immunogenicity
    Publication number: 20030022285
    Abstract: The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, proteins will be screened for MHC binding sequences, T cell epitopes and B cell epitopes.
    Type: Application
    Filed: January 4, 2002
    Publication date: January 30, 2003
    Inventors: Arthur J. Chirino, Bassil I. Dahiyat, John Desjarlais
  • Biochips comprising nucleic acid/protein conjugates
    Publication number: 20020172968
    Abstract: The present invention is directed to the formation of protein arrays through the use of nucleic acid/protein (NAP) conjugates, which allow the covalent attachment of proteins and the nucleic acids encoding them. By using vectors that include capture sequences that will hybridize to capture probes on a nucleic acid array, the NAP conjugates including the proteins of interest are arrayed and used in a wide variety of applications.
    Type: Application
    Filed: February 19, 2002
    Publication date: November 21, 2002
    Inventors: Hongxiang Liu, Bassil I. Dahiyat, Min Li
  • Biochips comprising nucleic acid/protein conjugates
    Publication number: 20020168640
    Abstract: The present invention is directed to the formation of protein arrays through the use of nucleic acid/protein (NAP) conjugates, which allow the covalent attachment of proteins and the nucleic acids encoding them. By using vectors that include capture sequences that will hybridize to capture probes on a nucleic acid array, the NAP conjugates including the proteins of interest are arrayed and used in a wide variety of applications.
    Type: Application
    Filed: February 22, 2001
    Publication date: November 14, 2002
    Inventors: Min Li, Bassil I. Dahiyat
  • Protein design automation for designing protein libraries with altered immunogenicity
    Publication number: 20020119492
    Abstract: The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, proteins will be screened for MHC binding sequences, T cell epitopes and B cell epitopes.
    Type: Application
    Filed: July 10, 2001
    Publication date: August 29, 2002
    Inventors: Arthur J. Chirino, Bassil I. Dahiyat
  • Design and discovery of protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
    Publication number: 20020110868
    Abstract: The invention relates to novel proteins with TNF-&agr; antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-&agr; related disorders, such as rheumatoid arthritis.
    Type: Application
    Filed: October 15, 2001
    Publication date: August 15, 2002
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Protein design automation for protein libraries
    Publication number: 20020090648
    Abstract: The invention relates to the use of protein design automation (P DA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: August 10, 2001
    Publication date: July 11, 2002
    Inventors: Bassil I Dahiyat, Joerg Bentzien, Klaus Fiebig, Robert Hayes
  • Protein design automatic for protein libraries
    Patent number: 6403312
    Abstract: The invention relates to the use of protein design automaton (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: June 11, 2002
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Jörg Bentzien, Klaus M. Fiebig
  • Protein design automation for protein libraries
    Publication number: 20020048772
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: February 12, 2001
    Publication date: April 25, 2002
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Joerg Bentzien, Klaus M. Fiebig
  • Design and discovery of protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
    Publication number: 20020009780
    Abstract: The invention relates to novel proteins with TNF-&agr; antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-&agr; related disorders, such as rheumatoid arthritis.
    Type: Application
    Filed: March 2, 2001
    Publication date: January 24, 2002
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Apparatus and method for automated protein design
    Publication number: 20020004706
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Application
    Filed: April 18, 2001
    Publication date: January 10, 2002
    Applicant: The California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Apparatus and method for automated protein design
    Publication number: 20010032052
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Application
    Filed: March 19, 2001
    Publication date: October 18, 2001
    Applicant: The California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. benjamin Gordon, Arthur Street, Yaoying Su
  • Apparatus and method for automated protein design
    Patent number: 6269312
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Apparatus and method for automated protein design
    Patent number: 6188965
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: February 13, 2001
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street