Patents by Inventor Bayard R. Huck

Bayard R. Huck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic amine azaheterocyclic carboxamides
    Patent number: 9586938
    Abstract: The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: March 7, 2017
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Xiaoling Chen, Constantin Neagu, Reinaldo Jones, Yufang Xiao, Igor Mochalkin
  • Heterocyclic derivatives as modulators of kinase activity
    Patent number: 9580443
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: February 28, 2017
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • Novel Heterocyclic Derivatives as Modulators of Kinase Activity
    Publication number: 20170015679
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 27, 2016
    Publication date: January 19, 2017
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO
  • NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160361316
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Inventors: Ruoxi LAN, Xiaoling CHEN, Yufang XIAO, Bayard R. HUCK, Andreas GOUTOPOULOS
  • AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES
    Publication number: 20160340323
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Bayard R. HUCK, Ruoxi LAN, Justin POTNICK, Lizbeth Celeste DESELM, Mark W. CRONIN, JR., Constantin NEAGU, Xiaoling CHEN, Roch BOIVIN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160339028
    Abstract: The invention provides novel heterocyclic carboxamide compounds compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Ruoxi LAN, Lizbeth Celeste DE SELM, Constantin NEAGU, Justin POTNICK, Srinivasa R. KARRA, Theresa L. JOHNSON
  • Heterocycles as modulators of kinase activity
    Patent number: 9458134
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 4, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R. Huck, Andreas Goutopoulos
  • Substituted pyrido[3,2-d]pyrimidines for treating cancer
    Patent number: 9440968
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 13, 2016
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Ruoxi Lan, Justin Potnick, Lizbeth Celeste Deselm, Mark W. Cronin, Jr., Constantin Neagu, Xiaoling Chen, Roch Boivin, Theresa L. Johnson, Andreas Goutopoulos
  • Pyrimidine imidazole amines as modulators of kinase activity
    Patent number: 9434714
    Abstract: The invention provides novel imidazole amine compounds according to formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: September 6, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R. Huck, Andreas Goutopoulos
  • AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160184308
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: March 3, 2016
    Publication date: June 30, 2016
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Lizbeth C. DESELM, Hui QIU, Yufang XIAO, Constantin NEAGU, Igor MOCHALKIN, Theresa L. JOHNSON
  • Aminopyrimidine derivatives for use as modulators of kinase activity
    Patent number: 9321760
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: April 26, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth Celeste Deselm, Hui Qiu, Yufang Xiao, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • Imidazol-piperidinyl derivatives as modulators of kinase activity
    Patent number: 9315517
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of formula (I) in which R1, R2, X1, X2, X3, X4 and n have the meanings indicated in above, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: April 19, 2016
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • Pyrido-pyrimidine derivatives
    Patent number: 9283225
    Abstract: Compounds of the formula I in which Het, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of RON and can be employed, for the treatment of cancer.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: March 15, 2016
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Oliver Schadt, Christine Knuehl, Manja Friese-Hamim, Bayard R. Huck, Andreas Goutopoulos, Nadia Brugger
  • NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160058763
    Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 8, 2015
    Publication date: March 3, 2016
    Inventors: Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Ruoxi LAN, Lizbeth Celeste DE SELM, Constantin NEAGU, Justin POTNICK, Srinivasa R. KARRA, Theresa L. JOHNSON
  • NOVEL HETEROCYCLES AS MODULATORS OF KINASE ACTIVITY
    Publication number: 20160016936
    Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 21, 2016
    Applicant: Merck Patent GmbH
    Inventors: Ruoxi LAN, Xiaoling CHEN, Yufang XIAO, Bayard R. HUCK, Andreas GOUTOPOULOS
  • Novel Imidazole Amines as Modulators of Kinase Activity
    Publication number: 20160000785
    Abstract: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Ruoxi LAN, Bayard R. HUCK, Xiaoling CHEN, Yufang XIAO, Lizbeth Celeste DESELM, Hui QIU, Constantin NEAGU, Donald BANKSTON, Christopher Charles Victor JONES
  • Novel Heterocyclic Derivatives as Modulators of Kinase Activity
    Publication number: 20150274750
    Abstract: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 1, 2015
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Yufang Xiao
  • Imidazole amines as modulators of kinase activity
    Patent number: 9145392
    Abstract: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: September 29, 2015
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Yufang Xiao, Xiaoling Chen, Lizbeth Celeste Deselm, Hui Qiu, Constantin Neagu, Donald Bankston, Christopher Charles Victor Jones
  • Heterocyclic carboxamides as modulators of kinase activity
    Patent number: 9139568
    Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I), their manufacture, and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: September 22, 2015
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Xiaoling Chen, Yufang Xiao, Ruoxi Lan, Lizbeth Celeste De Selm, Constantin Neagu, Justin Potnick, Srinivasa R. Karra, Theresa L. Johnson
  • AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES
    Publication number: 20150259339
    Abstract: Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
    Type: Application
    Filed: November 27, 2013
    Publication date: September 17, 2015
    Inventors: Bayard R. Huck, Ruoxi Lan, Justin Potnick, Lizbeth Celeste Deselm, Mark W. Cronin, JR., Constantin Neagu, Xiaoling Chen, Roch Boivin, Theresa L. Johnson, Andreas Goutopoulos