Abstract: A process for the preparation of a compound of formula (Ia): includes: (i) contacting a compound of formula (III): with a compound of formula (IV): in the presence of a palladium catalyst, methanol and hydrogen gas, the step (i) preferably being conducted under basic conditions with acetic acid being added to the medium of reaction once the consumption of the hydrogen gas has ceased.

Abstract: The invention relates to polymorphous forms of (+)-(S)-clopidogrel hydrogen bromide, described as polymorphous “form A”, polymorphous “form B”, polymorphous “form C”, polymorphous “form D”, polymorphous “form E”, and polymorphous “form F”, in addition to polymorphous forms of (+)-(S)-clopidogrel napsylate, that are described as polymorphous “form A” and polymorphous “form B” and differ in the X-ray powder diffraction diagrams (XRPD) thereof. The invention also relates to the salts clopidogrel besylate, clopidogrel tosylate and clopidogrel oxalate, and to methods for the production thereof.

Abstract: The present invention provides an efficient method of making O-desmethyl-venlafaxine.

Abstract: Process for the preparation of I-[cyano(phenyl)methyl]cyclohexanol compounds of general formula (I): in which R1 is hydrogen, (C1-4)alkyl or (C1-4)alkoxy, wherein a compound of general formula (II): in which R1 is as defined above, is reacted with cyclohexanone, the reaction being carried out in the presence of an organic or inorganic base, and this organic or inorganic base being present in the reaction mixture in at least an equimolar amount, based on the amount of the compound of general formula (II).

Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.

Abstract: A method for the preparation of 5-cyanophthalide in which 5-carboxyphthalide is reacted with a dehydrating agent, such as thionylchloride, and a sulphonamide, in particular sulfamide. Cyanophthalide is prepared in high yields by a convenient procedure. 5-cyanophthalide is an intermediate used in the preparation of the antidepressant drug citalopram.

Abstract: A method for the preparation of 5-cyanophthalide in which 5-carboxyphthalide is reacted with a dehydrating agent, such as thionylchloride, and a sulphonamide, in particular sulfamide. Cyanophthalide is prepared in high yields by a convenient procedure. 5-cyanophthalide is an intermediate used in the preparation of the antidepressant drug citalopram.

Abstract: A cryomagnet system, in particular for use with nuclear magnetic resonance (NMR) experiments or ion cyclotron resonance (ICR) experiments, with a low-loss helium cryostat (1) comprising a helium container (2) and one or a plurality of tubes for the feed or exit of helium into or out of the helium container (2), respectively, the tubes being sealed to the atmosphere outside the helium container (2) by at least one non-return low-pressure valve (4), wherein at least one exhaust pipeline (3) is provided with a device for dissipating the energy of the expanding helium. Such a device may consist of a chamber which is deviated from the exhaust pipeline (3) and has a wall material of very high extensibility, e.g. a folding balloon. Yet the device may also consist of a flow baffle which is provided in the exhaust pipeline (3), for example a porous disc (6).