Patents by Inventor Bee-Cheng Sim

Bee-Cheng Sim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME
    Publication number: 20240091315
    Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
    Type: Application
    Filed: March 13, 2023
    Publication date: March 21, 2024
    Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
  • CHIMERIC POLYPEPTIDE ASSEMBLY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20240018260
    Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
    Type: Application
    Filed: June 16, 2023
    Publication date: January 18, 2024
    Inventors: Volker SCHELLENBERGER, Fan YANG, Desiree THAYER, Bee-Cheng SIM, Chia-Wei WANG
  • CHIMERIC POLYPEPTIDE ASSEMBLY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20230295334
    Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
    Type: Application
    Filed: December 19, 2022
    Publication date: September 21, 2023
    Inventors: Volker SCHELLENBERGER, Fan YANG, Desiree THAYER, Bee-Cheng SIM, Chia-Wei WANG
  • Chimeric polypeptide assembly and methods of making and using the same
    Patent number: 11713358
    Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: August 1, 2023
    Assignee: AMUNIX PHARMACEUTICALS, INC.
    Inventors: Volker Schellenberger, Fan Yang, Desiree Thayer, Bee-Cheng Sim, Chia-Wei Wang
  • XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME
    Publication number: 20210322518
    Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
    Type: Application
    Filed: October 29, 2020
    Publication date: October 21, 2021
    Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
  • XTEN conjugate compositions and methods of making same
    Patent number: 10953073
    Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 23, 2021
    Assignee: Amunix Pharmaceuticals, Inc.
    Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
  • RELEASE SEGMENTS AND BINDING COMPOSITIONS COMPRISING SAME
    Publication number: 20200385469
    Abstract: The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.
    Type: Application
    Filed: December 20, 2018
    Publication date: December 10, 2020
    Inventors: Fan YANG, Volker SCHELLENBERGER, Vladimir PODUST, Bee-Cheng SIM, Desiree THAYER, John BEABER
  • CHIMERIC POLYPEPTIDE ASSEMBLY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190153115
    Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 23, 2019
    Inventors: Volker SCHELLENBERGER, Fan YANG, Desiree THAYER, Bee-Cheng SIM, Chia-Wei WANG
  • XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME
    Publication number: 20190083577
    Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant MCLAUGHLIN, Bee-Cheng Sim, Sheng Ding, Chen Gu
  • XTEN conjugate compositions and methods of making same
    Patent number: 10172953
    Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: January 8, 2019
    Assignee: Amunix Operating Inc.
    Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
  • Modified human four helical bundle polypeptides and their uses
    Patent number: 9260472
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: February 16, 2016
    Assignee: AMBRX, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. Dimarchi, Anna-Maria A. Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified Insulin Polypeptides and Their Uses
    Publication number: 20150299288
    Abstract: Modified insulin polypeptides and their uses thereof are provided
    Type: Application
    Filed: December 19, 2014
    Publication date: October 22, 2015
    Applicant: AMBRX, INC.
    Inventors: Zhenwei MIAO, Denise KRAWITZ, Vadim KRAYNOV, Tian FENG, Bee-Cheng SIM, Lillian SKIDMORE, Anna-Maria A. HAYS PUTNAM, Nick KNUDSEN, Michael DEGUZMAN
  • XTEN CONJUGATE COMPOSITIONS AND METHODS OF MAKING SAME
    Publication number: 20150037359
    Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
    Type: Application
    Filed: February 27, 2013
    Publication date: February 5, 2015
    Applicant: AMUNIX OPERATING, INC.
    Inventors: Volker Schellenberger, Vladimir Podust, Chia-Wei Wang, Bryant McLaughlin, Bee-Cheng Sim, Sheng Ding, Chen Gu
  • Modified insulin polypeptides and their uses
    Patent number: 8946148
    Abstract: Modified insulin polypeptides and their uses thereof are provided.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: February 3, 2015
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Denise Krawitz, Vadim Kraynov, Feng Tian, Bee-Cheng Sim, Lillian Skidmore, Anna-Maria A. Hays Putnam, Nick Knudsen, Michael Deguzman
  • Modified human four helical bundle polypeptides and their uses
    Patent number: 8906676
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: December 9, 2014
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified human four helical bundle polypeptides and their uses
    Patent number: 8907064
    Abstract: Modified human four helical bundle (4HB) polypeptides and uses thereof are provided.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: December 9, 2014
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified Human Growth Hormone Polypeptides and Their Uses
    Publication number: 20140296145
    Abstract: Modified human growth hormone polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 2, 2014
    Applicant: AMBRX, INC.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard DiMarchi, Anna-Maria Hays Putnam, Troy Wilson, Bee-Cheng Sim, David Litzinger
  • Human growth hormone modified at position 35
    Patent number: 8778880
    Abstract: Modified human growth hormone polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: July 15, 2014
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Modified human growth hormone
    Patent number: 8143216
    Abstract: Modified growth hormone polypeptide and uses thereof are provided.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: March 27, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Richard D. DiMarchi, Anna-Maria A. Hays, Troy E. Wilson, Bee-Cheng Sim, David C. Litzinger
  • Pegylated human interferon polypeptides
    Patent number: 8093356
    Abstract: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: January 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Anna-Maria A. Hays, Bruce E. Kimmel, Ho Sung Cho, Bee-Cheng Sim, David C. Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas O. Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow