Abstract: The present invention belongs to the field of the manufacture of recombinant proteins, particularly antibodies. More specifically, it relates to cell culture processes for expressing proteins with improved yield during commercial scale manufacturing.

Abstract: There is provided herein methods generating a population of primed mesenchymal stem cell-derived exosomes. A method in accordance with the disclosure may comprise expanding a population of mesenchymal stem cells (MSCs) in culture, administering one or more priming agents in the culture to prime the population of MSCs and obtain a population of primed MSCs: growing the population of die primed MCSs in culture to produce a primed-MSC-derived conditioned medium; collecting the primed MSC-conditioned medium; and purifying a population of exosomes from the primed MSC-conditioned medium. The one or more priming p agents may comprise a conditioned media derived from a population of stem cells different from the population of MSCs, a Nrf2 activator, or a combination thereof. There is also provided herein methods of treating tissues such as cornea and liver using the population of exosomes from the primed MSC-conditioned medium.

Abstract: Systems, methods, and computer readable media are described for modifying or updating a user interface. In some examples, systems, methods, and computer readable media include receiving, via an operator console on an operator system, one or more inputs for a template for a user interface, generating, based on the one or more inputs, the template for the user interface, and generating, based on the template, a plurality of designs for the user interface, wherein each design in the plurality of designs is associated with an interface profile.

Abstract: The present disclosure provides an improved cogwheel permitting enhanced meshing of cogwheels when operating perpendicularly. Exemplary embodiments introduce a multi-cogwheel design with specific dimensions and tooth profiles to permit perpendicular engagement of cogwheels whilst permitting translation of such cogwheels.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: A fan assembly, including a fan body including an inlet surface defining an air inlet. A motor-driven impeller contained within the fan body generates an airflow. A filter assembly is arranged to removably engage with the fan body and to cover at least a portion of the inlet surface when engaged with the fan body. The filter assembly includes a filter and a housing for the filter, the housing being provided with a filter retention assembly for releasably retaining the filter in the housing, and a user interface for actuating the filter retention assembly to release the filter from the housing. Upon actuation of the filter retention assembly via the user interface, the filter is free to slide relative to the housing. Preferably, the user interface is positioned on the housing.

Abstract: Systems, methods, and computer readable media are described for modifying or updating a user interface. In some examples, systems, methods, and computer readable media include receiving, via an operator console on an operator system, one or more inputs for a template for a user interface, generating, based on the one or more inputs, the template for the user interface, and generating, based on the template, a plurality of designs for the user interface, wherein each design in the plurality of designs is associated with an interface profile.

Abstract: Systems and methods for profiling a pallet in a warehouse can include a turntable that rotates the pallet, conveyor belts that move the pallet, and a vertical profiling structure, having cameras mounted at different locations, in a stationary position proximate to a side of the turntable. A photo booth can also be used to provide uniform lighting. A computing system can instruct a conveyor belt to automatically route the pallet onto the turntable, instruct the cameras to capture image data of the pallet as it rotates on the turntable, receive the image data, and retrieve image-based models of the pallet that were trained using images of pallets having unique identifiers. The computing system can determine, based on applying the image-based models to the image data, whether the pallet's unique identifier is identifiable, and transmit, to a warehouse management system, a notification indicating whether the unique identifier is identifiable.

Abstract: A nozzle for a fan assembly is described. The nozzle includes a first duct through which a first airflow moves, the first duct having a first outlet for emitting the first airflow. The nozzle further includes a second duct through which a second airflow moves, the second duct having a second outlet for emitting the second airflow. The first and second outlets are arranged such that the first and second airflows collide to generate a combined airflow having a direction defined by the relative flow rates of the first and second airflows. The first duct then includes a portion moveable to vary the flow rate of the first airflow.

Abstract: A nozzle for a fan assembly is described. The nozzle includes a first duct through which a first airflow moves, and a second duct through which a second airflow moves. The first duct has a first outlet for emitting the first airflow, and the second duct has a second outlet for emitting the second airflow. The first and the second outlets are arranged such that the first and second airflows collide to generate a combined airflow having a direction defined by the relative flow rates of the first and second airflows. The second duct has a constant restriction, and the first duct has a variable restriction to vary the flow rate of the first airflow.

Abstract: Embodiments are generally directed to compression in machine learning and deep learning processing. An embodiment of an apparatus for compression of untyped data includes a graphical processing unit (GPU) including a data compression pipeline, the data compression pipeline including a data port coupled with one or more shader cores, wherein the data port is to allow transfer of untyped data without format conversion, and a 3D compression/decompression unit to provide for compression of untyped data to be stored to a memory subsystem and decompression of untyped data from the memory subsystem.

Abstract: Systems and methods for profiling a pallet in a warehouse can include a turntable that rotates the pallet, conveyor belts that move the pallet, and a vertical profiling structure, having cameras mounted at different locations, in a stationary position proximate to a side of the turntable. A photo booth can also be used to provide uniform lighting. A computing system can instruct a conveyor belt to automatically route the pallet onto the turntable, instruct the cameras to capture image data of the pallet as it rotates on the turntable, receive the image data, and retrieve image-based models of the pallet that were trained using images of pallets having unique identifiers. The computing system can determine, based on applying the image-based models to the image data, whether the pallet's unique identifier is identifiable, and transmit, to a warehouse management system, a notification indicating whether the unique identifier is identifiable.

Abstract: There is provided a container maneuvering apparatus arranged to provide an interface between a container-conveying system and a container-storage system. More specifically, there is disclosed a container maneuvering apparatus arranged to load/unload a container into/from a carriage. Optionally, the carriage is a Magway carriage. The carriage can be made stationary before loading/unloading the container by the container-conveying system. The carriage and container can match velocities so that both are moving, but at the same velocity, whilst loading/unloading operations are performed by the container maneuvering apparatus.

Abstract: The present invention provides a transporting device for a storage system which maximises storage capacity of the storage system whilst remaining scalable and avoiding overheads. The transporting device includes a frame having a Z-direction track and a tray for supporting the container. The tray includes an X-direction movement unit arranged to move the container in an X-direction, a Y-direction movement unit arranged to move the container in a Y-direction and a Z-direction movement unit arranged to move the tray in a Z-direction by way of interaction with the Z-direction track. The transporting device can include a frame having a Z-direction track and a first movement unit arranged to move the container in an X-direction and/or a Z-direction by with the Z-direction track. A second movement unit is arranged to move the container in a Y-direction and/or a Z-direction.

Abstract: There is provided an air-treatment device including an airflow generator for generating an airflow, an adsorbent material for adsorbing one or more airborne contaminants, the adsorbent material being arranged such that at least a portion of the airflow passes through the adsorbent material, a heater arranged to heat a portion of the adsorbent material to desorb adsorbed contaminants, and a photocatalytic reactor arranged to receive air containing the contaminants desorbed from the heated portion of adsorbent material. The photocatalytic reactor includes a photo-catalyst for photocatalytic degradation of one or more of the contaminants, and one or more light sources for illuminating the photo-catalyst to facilitate photocatalytic degradation. The air-treatment device is arranged such that at least a portion of the airflow that has not passed through the heated portion of the adsorbent material contacts the one or more light sources.

Abstract: There is provided a photocatalytic reactor arranged to receive one or more airborne contaminants. The photocatalytic reactor includes a photo-catalyst for photocatalytic degradation of one or more of the contaminants disposed on a substrate, and a light-emitting diode circuit board comprising a circuit board with one or more first light-emitting diodes mounted to a first side of the circuit board and one or more second light-emitting diodes mounted to a second side of the circuit board. The substrate is arranged to be illuminated by both the one or more first light-emitting diodes and the one or more second light-emitting diodes in order to facilitate photocatalytic degradation.

Abstract: The present disclosure discloses methods for culturing stem cells in three-dimensional methods. Said method is either a spheroid-based method or a microcarrier-based method. The process as described herein leads to the expansion of the stem cells to obtain an expanded population of the stem cells, and a stem cell derived-conditioned medium. The present disclosure also discloses an expanded population of the stem cells, and a stem cell derived-conditioned medium obtained from the process as described herein. Further, an exosome preparation obtained from the stem cell derived-conditioned medium is also disclosed herein. The present disclosure also discloses a composition comprising an expanded population of the stem cells, or a stem cell derived-conditioned medium, or an exosome preparation, or combinations thereof. Methods of treatment using the composition as described herein is also disclosed in the present disclosure.

Abstract: In one embodiment, a mobile data analysis system generates mobile reports. In this context, a mobile report represents information collected by a mobile device user and provided as input to a report form displayed by an associated mobile device. The collected information may, for example, include information relating to an activity or event, information relating to a particular person, entity, or location, or any combination thereof. A mobile report may be based on a report template. A report template defines one or more data fields and other property information to be included in a mobile report. A mobile report may be sent to a server to generate one or more data objects, and one or more data object links between the data objects from a first mobile report, the data objects from a second mobile report, and exiting data objects that are maintained at the server.

Abstract: The present disclosure provides an improved cogwheel permitting enhanced meshing of cogwheels when operating perpendicularly. Exemplary embodiments introduce a multi-cogwheel design with specific dimensions and tooth profiles to permit perpendicular engagement of cogwheels whilst permitting translation of such cogwheels.