Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connection tubing configured to act as a fluid conduit between the vacuum source and the aspiration catheter. A controllable valve is configured to control a level of vacuum in the connection tubing provided by the vacuum source, and one or more pressure sensors are associated with the connection tubing. A controller is configured to periodically sample flow when the current flow state is unrestricted, utilize an artificial neural network to classify a flow state for the sampled flow, close the controllable valve if the flow state for the sampled flow is classified as unrestricted, and hold the controllable valve open if the flow state for the sampled flow is classified as restricted or obstructed.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: An aspiration thrombectomy system including an aspiration catheter having a proximal portion, a distal end and a lumen extending through the catheter, a vacuum source fluidically coupled to the catheter, a vacuum valve connected between the vacuum source and the proximal portion of the catheter to control a vacuum flow in the catheter lumen, a vent valve fluidically coupled to the proximal portion of the catheter, the vent valve being configured to control a flow of a vent fluid in the catheter lumen, and a controller configured to open and close the vacuum valve and the vent valve in a predetermined cycle to change a level of vacuum at the distal end of the catheter and to control fluid flow in and out from the distal end of the catheter.

Abstract: Embolic coil implant systems and methods whereby coils are mechanically detachable are disclosed. The coils include a retention element that may be releasably retained within the distal end of an implant tool. The implant tool may include a fulcrum configured to engage a first filament and prevent the release of the coil when the first filament is engaged. Alternatively, an urging means and aperture may be disposed within the sidewall of the implant tool, and a first filament may, in conjunction with the aperture and sidewall, releasably retain the coil until the first filament is withdrawn. The implant tool may also include an alignment member for aligning the first filament.

Abstract: A blood clot removal system including an aspiration catheter, an external unit having a first pressure sensor, a base unit having a second pressure sensor, a vacuum source connected to the base unit, connection tubing connecting the external unit to the aspiration catheter and the base unit, controllable sensory indicators, and a controller to receive a first pressure from the first pressure sensor and a second pressure from the second pressure sensor, determine a pressure differential based on the first pressure and the second pressure, determine a current catheter state from a plurality of catheter states based on the pressure differential, and transmit, via the one or more sensory indicators, one or more sensory indications of the current catheter state.

Abstract: A vascular cage comprises a self-expandable frame including a plurality of elongated flexible bands. The frame is configured to transition between a compressed configuration and an expanded configuration. The expanded frame may form a three-dimensional cage configured to surround an interior volume as the frame is deployed. At least some of the plurality of bands may have a substantially rectangular cross-section.

Abstract: An aspiration thrombectomy system, comprising an aspiration catheter having a proximal end and a distal end, wherein the proximal end of the aspiration catheter comprises a lumen configured to accommodate fluid, a vacuum source comprising a controllable vacuum valve, and a controller configured to detect a change in a connection between the aspiration catheter and the aspiration thrombectomy system, wherein the controller is further configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the connection between the aspiration catheter and the aspiration thrombectomy system, wherein the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: An aspiration thrombectomy system, comprising a vacuum source comprising a controllable vacuum valve, a pressure source comprising a controllable pressure valve, an aspiration catheter having a proximal end and a distal end, wherein the proximal end of the aspiration catheter comprises connection tubing having a lumen configured to accommodate fluid, and wherein the connection tubing acts as a common conduit for fluid communication between the aspiration catheter and the vacuum and pressure sources via the vacuum and pressure valves, respectively, and a controller configured to open and close the vacuum and vent valves in a predetermined cycle to change a level of vacuum at the distal end of the aspiration catheter and control flow in and out from the distal end of the catheter.

Abstract: An aspiration thrombectomy system, comprising a vacuum source comprising a controllable vacuum valve, a pressure source comprising a controllable pressure valve, an aspiration catheter having a proximal end and a distal end, wherein the proximal end of the aspiration catheter comprises connection tubing having a lumen configured to accommodate fluid, and wherein the connection tubing acts as a common conduit for fluid communication between the aspiration catheter and the vacuum and pressure sources via the vacuum and pressure valves, respectively, and a controller configured to open and close the vacuum and vent valves in a predetermined cycle to change a level of vacuum at the distal end of the aspiration catheter and control flow in and out from the distal end of the catheter.

Abstract: An aspiration thrombectomy system, comprising an aspiration catheter having a proximal end and a distal end, wherein the proximal end of the aspiration catheter comprises a lumen configured to accommodate fluid, a vacuum source comprising a controllable vacuum valve, and a controller configured to detect a change in a connection between the aspiration catheter and the aspiration thrombectomy system, wherein the controller is further configured to change a pulsation protocol associated with the aspiration catheter responsive to the change in the connection between the aspiration catheter and the aspiration thrombectomy system, wherein the pulsation protocol specifies pressure variations and pressure patterns to modulate the vacuum valve to change a level of vacuum at the distal end of the aspiration catheter.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: A vacuum aspiration control system for use with a vacuum source and an aspiration catheter includes a connecting tube configured to connect the vacuum source with a lumen of an aspiration catheter. An on-off valve is operatively coupled to the connecting tube, and a sensing unit is configured to detect flow within the connecting tube and provide a signal representative of flow. A controller receives the signal to decide whether to open or close the valve. The controller may automatically close the valve to stop flow when flow through the connecting tube is unrestricted, or according to a predetermined timing sequence. The controller can further periodically open a closed valve to determine whether flow has entered an acceptable range. The controller can still further engage pulsed aspiration with a pressure manipulation assembly when flow is restricted or occluded.

Abstract: Embolic coil implant systems and methods whereby coils are mechanically detachable are disclosed. The coils include a retention element that may be releasably retained within the distal end of an implant tool. The implant tool may include a fulcrum configured to engage a first filament and prevent the release of the coil when the first filament is engaged. Alternatively, an urging means and aperture may be disposed within the sidewall of the implant tool, and a first filament may, in conjunction with the aperture and sidewall, releasably retain the coil until the first filament is withdrawn. The implant tool may also include an alignment member for aligning the first filament.

Abstract: Vessel occlusion coils disclosed that have a primary configuration for delivery and a secondary configuration for deployment that is conferred upon the devices by a stretch resistant member. In the secondary configuration, the stretch resistant member forms a stiffer coil and may have a greater diameter, and a more complex shape having some interior space, at one end than at the other end, for improved anchoring of the device in the vessel. The methods include intravascular delivery and deployment for implanting one or more vessel occlusion devices.

Abstract: Embolic coil implant systems and methods whereby coils are mechanically detachable are disclosed. The coils include a retention element that may be releasably retained within the distal end of an implant tool. The implant tool may include a fulcrum configured to engage a first filament and prevent the release of the coil when the first filament is engaged. Alternatively, an urging means and aperture may be disposed within the sidewall of the implant tool, and a first filament may, in conjunction with the aperture and sidewall, releasably retain the coil until the first filament is withdrawn. The implant tool may also include an alignment member for aligning the first filament.

Abstract: A vascular cage comprises a self-expandable frame including a plurality of elongated flexible bands. The frame is configured to transition between a compressed configuration and an expanded configuration. The expanded frame may form a three-dimensional cage configured to surround an interior volume as the frame is deployed. At least some of the plurality of bands may have a substantially rectangular cross-section.

Abstract: A system for mechanically deploying intraluminal implants is disclosed. The system is used with an implant that is delivered and/or deployed via a pull wire and includes a handle having a funnel and receiving channel for receiving the pull wire, a slider having a thumb grip and a wedge, and a shuttle having a grabber for grasping the pull wire. The thumb grip is pulled proximally to retract the wedge to cause the grabber to grasp the wire and retract the shuttle but not the wire. An extension spring linked between the slider and the shuttle abruptly pulls the shuttle to retract the pull wire after the slider is fully retracted.