Patents by Inventor Benedetto Marelli

Benedetto Marelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11147282
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: October 19, 2021
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Benedetto Marelli, Mark Brenckle
  • Patent number: 11009792
    Abstract: The present application provides novel methods for the fabrication of nanostructures. More specifically, the invention relates to direct electron beam lithography with the use of silk fibroin as “green” resists.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 18, 2021
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Sunghwan Kim, Benedetto Marelli
  • Publication number: 20210098074
    Abstract: A method, computer system, and a computer program product for designing one or more folded structural proteins from at least one raw amino acid sequence is provided. The present invention may include computing one or more character embeddings based on the at least one raw amino acid sequence by utilizing a multi-scale neighborhood-based neural network (MNNN) model. The present invention may then include refining the computed one or more character embeddings with at least one set of sequence neighborhood information. The present invention may further include predicting one or more dihedral angles based on the refined one or more character embeddings.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 1, 2021
    Inventors: Lingfei Wu, Siyu Huo, Tengfei Ma, Pin-Yu Chen, Zhao Qin, Eugene Jungsup Lim, Francisco Javier Martin-Martinez, Hui Sun, Benedetto Marelli, Markus Jochen Buehler
  • Publication number: 20210002335
    Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
    Type: Application
    Filed: May 12, 2020
    Publication date: January 7, 2021
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Alexander Nicholas Mitropolous
  • Patent number: 10731046
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 4, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Publication number: 20200165306
    Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
    Type: Application
    Filed: August 7, 2019
    Publication date: May 28, 2020
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Alexander Nicholas Mitropolous
  • Publication number: 20200054792
    Abstract: The present application relates to amphiphilic polypeptide materials, methods for making and using the same. Provided amphiphilic polypeptide materials are water-based and manufactured using all aqueous processing. Provided materials exhibit a capacity to encapsulate and store biologically active molecules or macromolecules. Such biologically active molecules or macromolecules retain their structure and the biological activity so that these biologically active molecules or macromolecules are not materially degraded, reduced, and/or inhibited by processing steps or exposure. Provided materials possess unique mechanical and structural properties, including size, density, moldability and machinability.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 20, 2020
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Chunmei Li
  • Patent number: 10513802
    Abstract: Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 24, 2019
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Alexander Nicholas Mitropoulos
  • Publication number: 20190343137
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Application
    Filed: March 21, 2019
    Publication date: November 14, 2019
    Inventors: Fiorenzo Omenetto, David Kaplan, Benedetto Marelli, Mark Brenckle
  • Patent number: 10464361
    Abstract: The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and nano-engineering applications.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 5, 2019
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Miaomiao Yang, Hu Tao, Benedetto Marelli, Sunghwan Kim
  • Publication number: 20190177560
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Application
    Filed: July 6, 2018
    Publication date: June 13, 2019
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Patent number: 10271561
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: April 30, 2019
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Benedetto Marelli, Mark Brenckle
  • Patent number: 10035920
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 31, 2018
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Patent number: 9993525
    Abstract: A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: June 12, 2018
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING, MCGILL UNIVERSITY
    Inventors: Showan N. Nazhat, Benedetto Marelli, Giuliano Freddi, Antonio Alessandrino, Jake E. Barralet
  • Publication number: 20180000989
    Abstract: There is provided a method for preparing a dense hydrogel comprising an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.
    Type: Application
    Filed: August 18, 2017
    Publication date: January 4, 2018
    Inventors: Showan NAZHAT, Benedetto MARELLI, Chiara GHEZZI, Neysan Nejat Oliver KAMRANPOUR
  • Patent number: 9764060
    Abstract: There is provided a method for preparing a dense hydrogel comprising providing an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: September 19, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Showan Nazhat, Benedetto Marelli, Chiara Ghezzi, Neysan Nejat Oliver Kamranpour
  • Publication number: 20170156356
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Application
    Filed: March 6, 2015
    Publication date: June 8, 2017
    Inventors: Fiorenzo OMENETTO, David KAPLAN, Benedetto MARELLI, Mark BRENCKLE
  • Publication number: 20160281266
    Abstract: Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.
    Type: Application
    Filed: November 7, 2014
    Publication date: September 29, 2016
    Inventors: Fiorenzo OMENETTO, David KAPLAN, Benedetto MARELLI, Alexander Nicholas MITROPOULOS
  • Publication number: 20160237128
    Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
    Type: Application
    Filed: September 26, 2014
    Publication date: August 18, 2016
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Alexander Nicholas Mitropoulos
  • Publication number: 20160215103
    Abstract: This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.
    Type: Application
    Filed: September 26, 2014
    Publication date: July 28, 2016
    Inventors: Fiorenzo Omenetto, Giovanni Perotto, Benedetto Marelli, David Kaplan, Alexander Mitropoulos