Abstract: Compositions are provided that include a first product with a physical unclonable function (PUF) tag including silk particles conformably and directly attached to the first product, wherein the PUF tag cannot be reattached to a second product once removed from the first product.

Abstract: A system may include a memory and a processor in communication with the memory. The processor may be configured to perform operations. The operations may include training a neural network and predicting structural feature sets with the neural network. The operations may include producing predicted structures with the neural network using the structural feature sets, converting the predicted structures into predicted graphs with predicted edges, and comparing predicted graphs to training graphs and predicted edges to training edges to obtain a comparison. The operations may include training a model with the comparison, constructing a graph with the neural network using a node feature set, and reducing missing edges in the graph with the model.

Abstract: The invention provides a silk-based biomaterial designed to fabricate a microneedle-like device with controlled degradation rate in planta via tuning material composition and methods of manufacture thereof. The device enables precise access to xylem, phloem, and other plant tissues, thus being capable of serving as delivery tool to release cargo payloads and as sampling tool for analysis of plants fluid.

Abstract: The use of biological fertilizer combined with microbes can be used instead of herbicides, pesticides and synthetic fertilizers. Silk and trehalose dry films can be used as seed coatings to localize and quantify delivery of plant microbes to mitigate plant stress and soil salinity. Similar microbes can be delivered using the same technology.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: The present application provides novel methods for the fabrication of nanostructures. More specifically, the invention relates to direct electron beam lithography with the use of silk fibroin as “green” resists.

Abstract: A method, computer system, and a computer program product for designing one or more folded structural proteins from at least one raw amino acid sequence is provided. The present invention may include computing one or more character embeddings based on the at least one raw amino acid sequence by utilizing a multi-scale neighborhood-based neural network (MNNN) model. The present invention may then include refining the computed one or more character embeddings with at least one set of sequence neighborhood information. The present invention may further include predicting one or more dihedral angles based on the refined one or more character embeddings.

Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.

Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.

Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.

Abstract: The present application relates to amphiphilic polypeptide materials, methods for making and using the same. Provided amphiphilic polypeptide materials are water-based and manufactured using all aqueous processing. Provided materials exhibit a capacity to encapsulate and store biologically active molecules or macromolecules. Such biologically active molecules or macromolecules retain their structure and the biological activity so that these biologically active molecules or macromolecules are not materially degraded, reduced, and/or inhibited by processing steps or exposure. Provided materials possess unique mechanical and structural properties, including size, density, moldability and machinability.

Abstract: Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and nano-engineering applications.

Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.

Abstract: A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.

Abstract: There is provided a method for preparing a dense hydrogel comprising an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.