Patents by Inventor Benjamin Feldman

Benjamin Feldman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250040845
    Abstract: The present disclosure relates to a creatinine sensor comprising a first working electrode, a creatinine sensing layer on the first working electrode comprising a redox mediator, creatinine amidohydrolase, creatine amidinohydrolase, and sarcosine oxidase, and a hydrophilic polyurethane membrane overcoating the creatinine sensing layer. The creatinine sensor can further comprise a background sensing electrode that does not detect creatinine.
    Type: Application
    Filed: July 30, 2024
    Publication date: February 6, 2025
    Applicant: ABBOTT DIABETES CARE INC.
    Inventors: Cade FOX, Tianmei OUYANG, Yagya Raj OJHA, Zenghe LIU, Jonathan MCCANLESS, Benjamin FELDMAN
  • Publication number: 20240324913
    Abstract: The present invention relates to analyte sensors for use in detecting the concentration of potassium ions in a biological fluid and methods of using the sensors.
    Type: Application
    Filed: March 29, 2024
    Publication date: October 3, 2024
    Inventors: Zenghe Liu, Tram Nguyen, Benjamin Feldman
  • Patent number: 12076145
    Abstract: A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: September 3, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Kuan-Chou Chen, Tianmei Ouyang, Stephen Oja, Benjamin Feldman, Hyun Cho, Lam Tran, Mark Eshoo
  • Publication number: 20240164669
    Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
    Type: Application
    Filed: February 1, 2024
    Publication date: May 23, 2024
    Inventor: Benjamin Feldman
  • Patent number: 11918356
    Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: March 5, 2024
    Assignee: ABBOTT DIABETES CARE INC.
    Inventor: Benjamin Feldman
  • Patent number: 11918348
    Abstract: Medical devices configured for in vivo assays of one or more analytes can sometimes be problematic if left inserted in a tissue, such as skin, for an extended time. Certain medical device surface profiles may aid in alleviating this issue. Accordingly, medical devices may comprise a base surface having a tissue-facing surface profile defined thereon, and a sensor extending through the base surface and at least a portion of the tissue-facing surface profile. The tissue-facing surface profile deviates from the base surface, and the tissue-facing surface profile is also configured to undergo a change in shape, hardness, or a combination thereof after contacting a tissue for a length of time. A dynamic material may be present in at least a portion of the tissue-facing surface profile.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: March 5, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Jonathan McCanless, Hyun Brian Cho, Benjamin Feldman, Frank David Fujimoto
  • Publication number: 20220372542
    Abstract: Compositions of matter, methods, devices, systems and apparatus for detecting analytes are disclosed including, for example, protein switches and their use in an in vivo sensor. The protein switch can be used to determine a level of an analyte that is diagnostic for health and/or well-being of a subject.
    Type: Application
    Filed: October 1, 2020
    Publication date: November 24, 2022
    Inventors: Anthony Muerhoff, Thomas Leary, Christopher Marohnic, Barry Kreutz, Josie Corby, Benjamin Feldman, Tianmei Ouyang, Ahmed Wali, Oscar Alvizo
  • Publication number: 20220338763
    Abstract: In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 27, 2022
    Inventors: Mark ESHOO, Benjamin FELDMAN, Tianmei OUYANG, Lam TRAN
  • Patent number: 11432750
    Abstract: In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: September 6, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Mark Eshoo, Benjamin Feldman, Tianmei Ouyang, Lam Tran
  • Publication number: 20220265181
    Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
    Type: Application
    Filed: May 13, 2022
    Publication date: August 25, 2022
    Inventor: Benjamin Feldman
  • Publication number: 20220260517
    Abstract: A method for sensing an analyte utilizing a sensor, the sensor including a reference electrode and a working electrode including an analyte-specific enzyme and a redox mediator, where the method includes: providing the working electrode to the analyte; accumulating charge derived from the analyte reacting with the analyte-specific enzyme and the redox mediator; measuring a potential drift of the working electrode relative to the reference electrode over a period of time, and correlating a rate of the potential drift to a concentration of the analyte.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Inventors: Stephen M. Oja, Benjamin Feldman
  • Patent number: 11371957
    Abstract: A method for sensing an analyte utilizing a sensor having a working electrode, the method includes providing the working electrode with an analyte-specific enzyme and a redox mediator, providing the working electrode to the analyte, accumulating charge derived from the analyte reacting with the analyte-specific enzyme and the redox mediator for a set period of time, connecting the working electrode to circuit after the set period of time, and measuring the signal from the accumulated charge.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: June 28, 2022
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Stephen M. Oja, Benjamin Feldman
  • Patent number: 11357428
    Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: June 14, 2022
    Assignee: ABBOTT DIABETES CARE INC.
    Inventor: Benjamin Feldman
  • Publication number: 20190320947
    Abstract: A lactate-responsive enzyme may form the basis for lactate detection and quantification using an electrochemical analyte sensor. Various features may be incorporated within an analyte sensor containing a lactate-responsive enzyme, particularly lactate oxidase, to improve sensitivity and response stability of the analyte sensor. Such analyte sensors may comprise: a working electrode having an active area disposed thereon, and a mass transport limiting membrane overcoating at least the active area upon the working electrode. The active area comprises at least a polymer, an albumin, and a lactate-responsive enzyme that is covalently bonded to the polymer. The mass transport limiting membrane may comprise at least a crosslinked polyvinylpyridine homopolymer or copolymer. The analyte sensors may determine a lactate concentration in a biological fluid, particularly in vivo, which may be correlated to various physiological conditions.
    Type: Application
    Filed: January 28, 2019
    Publication date: October 24, 2019
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Kuan-Chou Chen, Tianmei Ouyang, Stephen Oja, Benjamin Feldman, Hyun Cho, Lam Tran, Mark Eshoo
  • Publication number: 20190167166
    Abstract: Medical devices configured for in vivo assays of one or more analytes can sometimes be problematic if left inserted in a tissue, such as skin, for an extended time. Certain medical device surface profiles may aid in alleviating this issue. Accordingly, medical devices may comprise a base surface having a tissue-facing surface profile defined thereon, and a sensor extending through the base surface and at least a portion of the tissue-facing surface profile. The tissue-facing surface profile deviates from the base surface, and the tissue-facing surface profile is also configured to undergo a change in shape, hardness, or a combination thereof after contacting a tissue for a length of time. A dynamic material may be present in at least a portion of the tissue-facing surface profile.
    Type: Application
    Filed: November 30, 2018
    Publication date: June 6, 2019
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Jonathan McCanless, Hyun Brian Cho, Benjamin Feldman, Frank David Fujimoto
  • Publication number: 20190125230
    Abstract: A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.
    Type: Application
    Filed: October 29, 2018
    Publication date: May 2, 2019
    Inventor: Benjamin Feldman
  • Publication number: 20190004005
    Abstract: A method for sensing an analyte utilizing a sensor having a working electrode, the method includes providing the working electrode with an analyte-specific enzyme and a redox mediator, providing the working electrode to the analyte, accumulating charge derived from the analyte reacting with the analyte-specific enzyme and the redox mediator for a set period of time, connecting the working electrode to circuit after the set period of time, and measuring the signal from the accumulated charge.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 3, 2019
    Inventors: Stephen M. Oja, Benjamin Feldman
  • Publication number: 20170258378
    Abstract: In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.
    Type: Application
    Filed: March 13, 2017
    Publication date: September 14, 2017
    Inventors: Mark Eshoo, Benjamin Feldman, Tianmei Ouyang, Lam Tran
  • Patent number: 9668684
    Abstract: Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: June 6, 2017
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin Feldman, Zenghe Liu, Tianmei Ouyang
  • Patent number: 8666470
    Abstract: The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: March 4, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adam Heller, Pawel Rowinski, Benjamin Feldman