Patents by Inventor Benjamin Feldman
Benjamin Feldman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090095642Abstract: Enzyme-based electrochemical sensors comprising transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators and include substituted or unsubstituted pyridyl-imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.Type: ApplicationFiled: April 14, 2008Publication date: April 16, 2009Inventors: Tianmei Ouyang, Zenghe Liu, John LaTour, Ting Chen, Lam N. Tran, Benjamin Feldman, Fei Mao, Adam Heller
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Publication number: 20080318261Abstract: A sensor designed to determine the concentration of analyte in a sample having a volume of less than about 1 ?L. The sensor has a working electrode coated with a redox mediator that acts as an electron transfer agent between the analyte and the electrode. A second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. Various electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can be used to determine the analyte concentration. The sensor can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum.Type: ApplicationFiled: January 13, 2005Publication date: December 25, 2008Applicant: Abbott Diabetes Care Inc.Inventors: ADAM HELLER, BENJAMIN FELDMAN, JAMES SAY, MARK VREEKE
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Publication number: 20080177164Abstract: The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.Type: ApplicationFiled: November 30, 2007Publication date: July 24, 2008Inventors: Adam Heller, Pawel Rowinski, Benjamin Feldman
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Publication number: 20080081969Abstract: The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.Type: ApplicationFiled: October 30, 2007Publication date: April 3, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: Benjamin Feldman, Geoffrey McGarraugh
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Publication number: 20080071157Abstract: Devices and methods for monitoring an analyte are provided. Embodiments include continuous analyte sensors having a high degree of accuracy.Type: ApplicationFiled: June 7, 2007Publication date: March 20, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: Geoffrey McGarraugh, Benjamin Feldman, Thomas Peyser, John Mazza, Timothy Goodnow, Kerstin Rebrin
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Publication number: 20080071158Abstract: Devices and methods for monitoring an analyte are provided. Embodiments include continuous analyte sensors having a high degree of accuracy.Type: ApplicationFiled: June 7, 2007Publication date: March 20, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: Geoffrey McGarraugh, Benjamin Feldman, Thomas Peyser, John Mazza, Timothy Goodnow, Kerstin Rebrin
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Publication number: 20080066305Abstract: A sensor, and methods of making, for determining the concentration of an analyte, such as glucose, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and may include an insertion monitoring trace to determine correct positioning of the sensor in a connector. The sensor is calibration-adjusted, eliminating the need for a user to enter a calibration code or for the meter to read a calibration code.Type: ApplicationFiled: October 30, 2007Publication date: March 20, 2008Applicant: Abbott Diabetes Care Inc.Inventors: Yi Wang, Benjamin Feldman
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Publication number: 20080064937Abstract: Devices and methods for monitoring an analyte are provided. Embodiments include continuous analyte sensors having a high degree of accuracy.Type: ApplicationFiled: June 7, 2007Publication date: March 13, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: Geoffrey McGarraugh, Benjamin Feldman, Thomas Peyser, John Mazza, Timothy Goodnow, Kerstin Rebrin
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Publication number: 20080060196Abstract: A sensor, and methods of making, for determining the concentration of an analyte, such as glucose, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and may include an insertion monitoring trace to determine correct positioning of the sensor in a connector. The sensor is calibration-adjusted, eliminating the need for a user to enter a calibration code or for the meter to read a calibration code.Type: ApplicationFiled: October 30, 2007Publication date: March 13, 2008Applicant: Abbott Diabetes Care Inc.Inventors: Yi Wang, Benjamin Feldman
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Publication number: 20080058625Abstract: Devices and methods for monitoring an analyte are provided. Embodiments include continuous analyte sensors having a high degree of accuracy.Type: ApplicationFiled: June 7, 2007Publication date: March 6, 2008Applicant: Abbott Diabetes Care, Inc.Inventors: Geoffrey McGarraugh, Benjamin Feldman, Thomas Peyser, John Mazza, Timothy Goodnow, Kerstin Rebrin
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Patent number: 7335294Abstract: An integrated lancing and measurement device is provided comprising a sensor designed to determine the amount and/or concentration of analyte in a biological fluid having a volume of less than about 1 ?L. A piercing member is adapted to pierce and retract from a site on the patient to cause the fluid to flow therefrom, and the sensor is positioned adjacent to the site on the patient so as to receive the fluid flowing from the site to generate an electrical signal indicative of the concentration of the analyte in the fluid. The sensor is comprised of a working electrode comprising an analyte-responsive enzyme and a redox mediator, and a counter electrode. An analyte monitor is operatively connected to the sensor and adapted to measure the signal generated by the sensor. Also provided are analyte measuring methods that optionally employ the integrated lancing and measurement device.Type: GrantFiled: July 28, 2003Date of Patent: February 26, 2008Assignee: Abbott Diabetes Care, Inc.Inventors: Adam Heller, Benjamin Feldman, James Say
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Publication number: 20080017522Abstract: An integrated lancing and measurement device is provided comprising a sensor designed to determine the amount and/or concentration of analyte in a biological fluid having a volume of less than about 1 ?L. A piercing member is adapted to pierce and retract from a site on the patient to cause the fluid to flow therefrom, and the sensor is positioned adjacent to the site on the patient so as to receive the fluid flowing from the site to generate an electrical signal indicative of the concentration of the analyte in the fluid. The sensor is comprised of a working electrode comprising an analyte-responsive enzyme and a redox mediator, and a counter electrode. An analyte monitor is operatively connected to the sensor and adapted to measure the signal generated by the sensor. Also provided are analyte measuring methods that optionally employ the integrated lancing and measurement device.Type: ApplicationFiled: July 30, 2007Publication date: January 24, 2008Applicant: TheraSense, Inc.Inventors: Adam Heller, Benjamin Feldman, James Say
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Publication number: 20070227911Abstract: In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.Type: ApplicationFiled: March 29, 2006Publication date: October 4, 2007Inventors: Yi WANG, Benjamin Feldman, Jared Watkin
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Publication number: 20070203407Abstract: An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided.Type: ApplicationFiled: February 28, 2006Publication date: August 30, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: Udo Hoss, Zenghe Liu, Benjamin Feldman
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Publication number: 20070193019Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: ApplicationFiled: April 13, 2007Publication date: August 23, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: Benjamin Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph Vivolo, Jeffery Funderburk, Fredric Colman, Rajesh Krishnan
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Publication number: 20070191701Abstract: An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.Type: ApplicationFiled: April 11, 2007Publication date: August 16, 2007Applicant: ABBOTT DIABETES CARE, INC.Inventors: Benjamin Feldman, Zenghe Liu, David Cohen, Adam Heller
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Publication number: 20070149875Abstract: Devices and methods for determining the concentration of an analyte are provided. Embodiments of the subject devices include analyte monitoring systems that include an analyte sensor capable of providing clinically accurate analyte data without a substantial time delay after operably positioning the sensor in a patient. Embodiments of the subject methods include operably positioning an analyte sensor in a patient and obtaining clinically accurate analyte data without a substantial time delay after the positioning. Also provided are systems and kits for use in analyte monitoring.Type: ApplicationFiled: December 28, 2005Publication date: June 28, 2007Applicant: Abbott Diabetes Care, Inc.Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin Feldman
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Publication number: 20070068807Abstract: In vitro electrochemical sensors that provide accurate and repeatable analysis of a sample of biological fluid are provided. Embodiments include sensors that include a sample chambers having overhangs extending therefrom.Type: ApplicationFiled: September 27, 2005Publication date: March 29, 2007Inventors: Benjamin Feldman, Yi Wang
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Publication number: 20060169599Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: ApplicationFiled: April 13, 2006Publication date: August 3, 2006Applicant: TheraSense, Inc.Inventors: Benjamin Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph Vivolo, Jeffery Funderburk, Fredric Colman, Rajesh Krishnan
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Publication number: 20050278945Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.Type: ApplicationFiled: September 12, 2003Publication date: December 22, 2005Applicant: TheraSense, Inc.Inventors: Benjamin Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph Vivolo, Jeffery Funderburk, Fredric Colman, Rajesh Krishnan