Patents by Inventor Benjamin Kleinstiver

Benjamin Kleinstiver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unconstrained Genome Targeting with near-PAMless Engineered CRISPR-Cas9 Variants
    Publication number: 20210284978
    Abstract: Streptococcus pyogenes Cas9 (SpCas9) variants with relaxed PAM requirements capable of high-resolution editing for various applications, and methods of use thereof.
    Type: Application
    Filed: January 25, 2021
    Publication date: September 16, 2021
    Inventors: Benjamin Kleinstiver, Russell T. Walton
  • Variants of CPF1 (CAS12a) With Altered PAM Specificity
    Publication number: 20210269788
    Abstract: Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with improved targeting range and enhanced on-target activity, and their use in genomic engineering, epigenomic engineering, base editing, genome targeting, genome editing, and in vitro diagnostics.
    Type: Application
    Filed: April 29, 2021
    Publication date: September 2, 2021
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Alexander Sousa
  • CRISPR-CAS ENZYMES WITH ENHANCED ON-TARGET ACTIVITY
    Publication number: 20210261932
    Abstract: Engineered versions of Streptococcus pyogenes Cas9 (SpCas9) and SpCas9 variants that have improved on-target editing capabilities, and methods of use thereof.
    Type: Application
    Filed: January 25, 2021
    Publication date: August 26, 2021
    Inventors: Benjamin Kleinstiver, Russell T. Walton
  • Engineered CRISPR-Cas9 nucleases
    Patent number: 11060078
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: July 13, 2021
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Methods for increasing efficiency of nuclease-induced homology-directed repair
    Patent number: 11021718
    Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: June 1, 2021
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Jason Michael Gehrke, Shengdar Tsai, James Angstman, Rebecca Tayler Cottman
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20200399621
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20200399620
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 24, 2020
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with altered PAM specificity
    Patent number: 10808233
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: October 20, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with altered PAM specificity
    Patent number: 10767168
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: September 8, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20200149023
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: November 18, 2019
    Publication date: May 14, 2020
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 Nucleases
    Publication number: 20200149024
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Application
    Filed: January 6, 2020
    Publication date: May 14, 2020
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 Nucleases
    Publication number: 20200140835
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Application
    Filed: June 6, 2018
    Publication date: May 7, 2020
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Janice Sha Chen, Jennifer Doudna, Yavuz Selim Dagdas, Ahmet Yildiz
  • Engineered CRISPR-Cas9 nucleases
    Patent number: 10633642
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: April 28, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 nucleases
    Patent number: 10526591
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 7, 2020
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 nucleases with altered PAM specificity
    Patent number: 10479982
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: November 19, 2019
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 Nucleases with Altered PAM Specificity
    Publication number: 20190106687
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: August 22, 2018
    Publication date: April 11, 2019
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 Nucleases
    Publication number: 20190071657
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Application
    Filed: October 9, 2018
    Publication date: March 7, 2019
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 nucleases with altered PAM specificity
    Patent number: 10202589
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: February 12, 2019
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Variants of CPF1 (CAS12a) With Altered PAM Specificity
    Publication number: 20190010481
    Abstract: Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with improved targeting range and enhanced on-target activity, and their use in genomic engineering, epigenomic engineering, base editing, genome targeting, genome editing, and in vitro diagnostics.
    Type: Application
    Filed: April 23, 2018
    Publication date: January 10, 2019
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Alexander Sousa
  • Engineered CRISPR-Cas9 nucleases
    Patent number: 10093910
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: October 9, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak