Patents by Inventor Benjamin Kleinstiver

Benjamin Kleinstiver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered CRISPR-Cas9 Nucleases with Altered PAM Specificity
    Publication number: 20180282714
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: March 26, 2018
    Publication date: October 4, 2018
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • METHODS FOR INCREASING EFFICIENCY OF NUCLEASE-INDUCED HOMOLOGY-DIRECTED REPAIR
    Publication number: 20180230494
    Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
    Type: Application
    Filed: October 1, 2015
    Publication date: August 16, 2018
    Inventors: J. Keith JOUNG, Benjamin KLEINSTIVER, Jason Michael GEHRKE, Shengdar TSAI, James ANGSTMAN, Rebecca Tayler COTTMAN
  • Engineered CRISPR-Cas9 Nucleases
    Publication number: 20180216088
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 2, 2018
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 nucleases with altered PAM specificity
    Patent number: 9944912
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: April 17, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-CAS9 nucleases with altered PAM specificity
    Patent number: 9926545
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: March 27, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases
    Patent number: 9926546
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: March 27, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
    Publication number: 20180030425
    Abstract: Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics.
    Type: Application
    Filed: July 25, 2017
    Publication date: February 1, 2018
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20180002681
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: March 3, 2016
    Publication date: January 4, 2018
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20170327806
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: July 31, 2017
    Publication date: November 16, 2017
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20170327804
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: March 3, 2016
    Publication date: November 16, 2017
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-CAS9 nucleases with altered PAM specificity
    Patent number: 9752132
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: September 5, 2017
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 Nucleases
    Publication number: 20170081650
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Application
    Filed: December 5, 2016
    Publication date: March 23, 2017
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 Nucleases
    Publication number: 20170058271
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenotnic engineering, genome targeting, and genome editing.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 nucleases
    Patent number: 9512446
    Abstract: Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: December 6, 2016
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20160319260
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: March 3, 2016
    Publication date: November 3, 2016
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
    Publication number: 20160319261
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: March 3, 2016
    Publication date: November 3, 2016
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-CAS9 NUCLEASES WITH ALTERED PAM SPECIFICITY
    Publication number: 20160312198
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: July 12, 2016
    Publication date: October 27, 2016
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Engineered CRISPR-CAS9 Nucleases with Altered PAM Specificity
    Publication number: 20160312199
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Application
    Filed: July 12, 2016
    Publication date: October 27, 2016
    Inventors: J. Keith Joung, Benjamin Kleinstiver