Patents by Inventor Benjamin M. Wu

Benjamin M. Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220323616
    Abstract: Antibodies which bind selectively to cardiac conduction system (CCS) cells, imaging and/or diagnostic reagents and compositions visualizing the CCS cells and therapeutic products and compositions comprising one or more of the antibodies. Methods for delivering therapeutic agents to the CCS cells. The disclosure further provides methods for visualizing the CCS cells in vivo in real time, including in a subject undergoing a cardiothoracic surgery or other cardiac intervention. Compositions and methods for isolation, purification, analyses and/or transplantation of the CCS cells, including pluripotent stem cell (hiPSC)-derived or human embryonic stem cell (hESC)-derived CCS cells.
    Type: Application
    Filed: July 7, 2020
    Publication date: October 13, 2022
    Inventors: Sean M. Wu, William R. Goodyer, Benjamin Beyersdorf, Nynke Van Den Berg, Eben Rosenthal
  • Publication number: 20220203359
    Abstract: The present invention relates to a near-field acoustic platform capable of synthesizing high resolution, arbitrarily shaped energy potential wells. A thin and viscoelastic membrane is utilized to modulate acoustic wavefront on a deep, sub-wavelength scale by suppressing the structural vibration selectively on the platform. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 30, 2022
    Inventors: Pei Yu E. Chiou, Kuan-Wen Tung, Benjamin M. Wu
  • Patent number: 11287426
    Abstract: In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×106 cells/mL, less than about 3×106 cells/ml, less than about 1×106 CFU/mL, or less than about 50 ?g/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 29, 2022
    Assignee: The Regents of the University of California
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Publication number: 20220001019
    Abstract: The present invention discloses a random conjugate molecule (CMN), comprising a formula of CG-X-N and methods of making and using the same. The present invention also discloses a composition comprising the CMN and methods of making and using the composition.
    Type: Application
    Filed: April 3, 2020
    Publication date: January 6, 2022
    Inventors: B. Chia Soo, Kang Ting, Benjamin M. Wu
  • Publication number: 20210238335
    Abstract: The present invention relates in part to a photocurable resin composition comprising a first compound formed from the reaction of a diisocyanate and an isocyanate reactive compound comprising a double bond, a second compound comprising one or more double bonds susceptible to polymerization, and a photoinitiator. The invention also relates in part to a method of making the photocurable resin composition. The invention also relates in part to a method of fabricating an article comprising the steps of providing a photocurable resin composition comprising a first compound formed from the reaction of a diisocyanate and an isocyanate reactive compound comprising a double bond, a second compound comprising one or more double bonds susceptible to polymerization, and a photoinitiator; 3D printing the photocurable resin to form an article; and curing the article. The invention also relates in part to a 3D printed resin article.
    Type: Application
    Filed: April 19, 2021
    Publication date: August 5, 2021
    Inventors: Benjamin M. Wu, Giovanny F. Acosta-Vélez
  • Publication number: 20190275160
    Abstract: The present invention discloses a bone-targeting therapeutic conjugate comprising a formula of TG-M-D (I) or M-D-TG (II) and methods of making and using the same. The present invention also discloses a composition comprising the conjugate and methods of making and using the composition.
    Type: Application
    Filed: March 14, 2017
    Publication date: September 12, 2019
    Inventors: B. Chia Soo, Ting Kang, Benjamin M. Wu
  • Patent number: 10391310
    Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: August 27, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wentai Liu, James C. Y. Dunn, Benjamin M. Wu, Yi-Kai Lo, Chih-Wei Chang, Justin P. Wagner
  • Patent number: 10359423
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: July 23, 2019
    Assignee: The Regents of the University of California
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Patent number: 10335458
    Abstract: Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: July 2, 2019
    Assignee: The Regents of the University of California
    Inventors: Chia Soo, Kang Ting, Shunichi Kuroda, Benjamin M. Wu
  • Publication number: 20190033308
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Application
    Filed: May 25, 2018
    Publication date: January 31, 2019
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Publication number: 20180259521
    Abstract: In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×106 cells/mL, less than about 3×106 cells/ml, less than about 1×106 CFU/mL, or less than about 50 ?g/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.
    Type: Application
    Filed: September 2, 2016
    Publication date: September 13, 2018
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Patent number: 10006911
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: June 26, 2018
    Assignee: The Regents of the University of California
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Publication number: 20180100854
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Application
    Filed: October 18, 2017
    Publication date: April 12, 2018
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Patent number: 9823247
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: November 21, 2017
    Assignee: The Regents of the University of California
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Publication number: 20170312393
    Abstract: Provided herein is a wound-healing-enhancing device that comprises a body structure and a wound-healing-enhancing agent in a wound-healing-enhancing effective amount. Methods of fabricating and using the device are also provided.
    Type: Application
    Filed: June 8, 2017
    Publication date: November 2, 2017
    Inventors: B. Chia SOO, Kang TING, Zhong ZHENG, Benjamin M. WU, Yulong ZHANG
  • Publication number: 20170266440
    Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 21, 2017
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wentai Liu, James C.Y. Dunn, Benjamin M. Wu, Yi-Kai Lo, Chih-Wei Chang, Justin P. Wagner
  • Publication number: 20170182207
    Abstract: Provided herein is a biocompatible device comprising a body structure and a wound-healing-enhancing agent in a wound-healing-enhancing effective amount, wherein the wound-healing-enhancing agent is embedded within the body structure or coated on the body structure. An example of the device is a surgical suture. Methods of fabricating and using the device are also provided.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 29, 2017
    Inventors: B. Chia SOO, Kang TING, Zhong ZHENG, Benjamin M. WU, Yulong ZHANG
  • Publication number: 20150305914
    Abstract: A multi-layer cast for immobilizing a body member of a patient includes a hydrophobic sleeve having a shape configured to be applied over the body member and substantially conform to the shape of the body member, and a moldable layer configured to be positioned around said sleeve and hardened to conform to the shape of said body member adjacent said sleeve is presented. The hydrophobic sleeve includes fibers configured to wick moisture outward away from the body member, and the moldable layer includes a network of pores that extend through the moldable layer such that the pores are configured to contact the hydrophobic sleeve to promote flow of moisture from the hydrophobic sleeve outward through the moldable layer. An external removable wrap may also be detachably disposed around the moldable layer for additional support and moisture wicking.
    Type: Application
    Filed: April 30, 2015
    Publication date: October 29, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Benjamin M. Wu, Jeffrey C. Wang, Emily W. Loughran
  • Publication number: 20150253320
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Inventors: Daniel T. Kamei, Yin To Chiu, Benjamin M. Wu, Garrett L. Mosley
  • Publication number: 20150094518
    Abstract: The invention provides a novel polymer platform to deliver a desired combination of therapeutic agents to a site in need thereof for the treatment of cancer. In certain embodiments the platform is a modular polymer platform that allows for customization based upon the tumor of the subject to be treated.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 2, 2015
    Inventors: Benjamin M. Wu, Maie A.R. St. John, Arnold Suwarnasam, Linda Wang, Yuan Lin, Jie Luo, Eric Zhu, Ontario D. Lau