Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.

Abstract: A system of Ocean-based barges following slow speed annual migration patterns that can net more incident solar energy, per unit area, than ever previously disclosed. This system makes use of solar radiant energy, seawater, and air to make most of the fuels/chemicals necessary for human life. These chemicals and/or fuels can then be efficiently distributed anywhere in the World by use of slow speed/low drag force travel, ocean currents, and/or transiting cargo ships. This system can power the entire Worlds global shipping industry, serve as an international decentralized energy grid, and/or provide a stored renewable energy reservoir of 100+ years.

Abstract: A system for improving drill bit performance, comprising processors and memory storing instructions to obtain a wear report for a drill bit, wherein the wear report includes wear characteristics of the drill bit and drill operating parameters under which the drill bit was used; compare the wear characteristics of the drill bit to a threshold for acceptable drill bit wear; and adjust drill operating parameters based on the wear characteristics of the drill bit. The instructions to obtain the wear report for the drill bit include instructions to analyze images of the drill bit to identify wear characteristics; identify wear patterns based on the wear characteristics of the drill bit; identify probable drilling conditions based on the wear patterns; and generate the wear report for the drill bit based on the images of the drill bit, the wear characteristics of the drill bit, and the probable drilling conditions.

Abstract: Novel methods for making high resolution oligonucleotide paints are provided. Novel, high resolution oligonucleotide paints are also provided.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A method for mutual authentication between user equipment and a communications network. The network includes a mobility management entity and a home subscriber server. The method, implemented by the user equipment, includes: receiving an authentication challenge having an token based on a first index and a first authentication message calculated by the home subscriber server and based on a first sequence number; checking that a condition of a set is true, the set including: the first sequence number is the same as a second sequence number stored in the user equipment, and the first sequence number is the same as a preceding value of the second sequence number and the first index is higher than a second index stored in the client equipment; and calculating and sending, when a condition is true, an authentication result and an authentication message, based on the preceding value of the second sequence number.

Abstract: Embodiments of the systems described herein can implement one or more visitor tearing processes. Visitor tearing can include, among other things, one or more processes by which multiple visitors that may appear to be the same visitor may be separated into different visitor profiles due to the leveraging of one or more unique persistent identifiers.

Abstract: Novel methods for making high resolution oligonucleotide paints are provided. Novel, high resolution oligonucleotide paints are also provided.

Abstract: A system for improving drill bit performance, comprising processors and memory storing instructions to obtain a wear report for a drill bit, wherein the wear report includes wear characteristics of the drill bit and drill operating parameters under which the drill bit was used; compare the wear characteristics of the drill bit to a threshold for acceptable drill bit wear; and adjust drill operating parameters based on the wear characteristics of the drill bit. The instructions to obtain the wear report for the drill bit include instructions to analyze images of the drill bit to identify wear characteristics; identify wear patterns based on the wear characteristics of the drill bit; identify probable drilling conditions based on the wear patterns; and generate the wear report for the drill bit based on the images of the drill bit, the wear characteristics of the drill bit, and the probable drilling conditions.

Abstract: A multi-factor user authentication framework using asymmetric key includes a host device, a user agent, a gesture system, and an authentication system. The multiple factors include a user credential as well as a user gesture that indicates that the user is present. The user interacts with the user agent via the host device in order to obtain access to something for which user authentication is needed. The authentication system maintains the user credentials, which are provided to authenticate the user in response to the authentication system determining that the user is present (which can be determined in different manners, such as using a personal identification number (PIN), biometric information regarding the user, geographic location of the gesture system, etc.). The user agent, gesture system, and authentication system can be implemented on the same device (e.g., the host device), or alternatively implemented across one or more different devices.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2, R30, R31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

Abstract: A method of fabricating a multijunction solar cell panel by providing a plurality of multijunction solar cells; dispensing out uncured silicone coating on the solar cells using an automated process with visual recognition, and curing the silicone coating on the solar cell to complete the Cell-Interconnect-Cover Glass (CIC) assembly.

Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.

Abstract: A space-qualified solar cell assembly comprising a plurality of space-qualified solar cells mounted on a support, the support comprising a plurality of conductive vias extending from the top surface to the rear surface of the support. Each one of the pluralities of space-qualified solar cells is placed on the top surface with the first contact of a first polarity of the space-qualified solar cell electrically connected to the first conductive via. A second contact of a second polarity of each space-qualified solar cell can be connected to a second conductive via so that the first and second conductive portions form terminals of opposite conductivity type. The space-qualified solar cells on the module can be interconnected to form a string or an electrical series and/or parallel connection by suitably interconnecting the terminal pads of the vias on the back side of the module.

Abstract: Authenticating an E-tournament identity using personal identity credentials. A method includes determining that a gaming device is configured for use in an E-tournament. The method further includes receiving from the device, user personal identity credentials. As a result, the method further includes, signing in to an E-tournament identity using the personal identity credentials.

Abstract: The present disclosure provides methods of fabricating a multijunction solar cell panel in which one or more of the steps are performed using an automated process. In some embodiments, the automated process uses machine vision.

Abstract: A pneumatic robotic tool, such as grinder, sander, etc., implements passive force control and compliance using two or more double-acting pneumatic pistons distributed about a pneumatic motor within the tool housing. The multiple pistons facilitate a compact design, reducing tool stack height, as compared to prior-art, single-piston designs. In one embodiment, filtered breather vents and an air pressure equalization passage maintain ambient atmospheric pressure throughout the tool, while preventing the infiltration of dust and other particulates. In one embodiment, a hard port rigidly affixed to the tool housing is provided for at least motor supply pneumatic fluid. The motor supply air is transferred from the hard port to the pneumatic motor via a flexible pneumatic fluid tube within the tool housing. In one embodiment, the pneumatic motor discharge air is vented from the tool housing in a sealed passage that accommodates the tool compliance motion, and prevents dust infiltration.

Abstract: A fluid management system and method includes a thermal management system disposed within a housing that includes conduits extending between a source and a destination of a first fluid. The first fluid exchanges heat with cooling devices as the first fluid moves between the source and the destination. A fluid mixture including the first fluid and a second fluid, and an exhaust are generated responsive to the first fluid exchanging heat with the cooling devices. The exhaust directed toward an outlet of the housing. A separator assembly fluidly coupled with and disposed downstream of the thermal management system receives the fluid mixture and separates the first fluid from the second fluid. The first fluid is directed in a first direction out of the separator assembly and the second fluid is directed toward the outlet to be combined with the exhaust.

Abstract: A system that may include a bus bar that may include a mounting bracket configured to electrically couple the bus bar to a motor. The mounting bracket may also be configured to be removably coupled to the motor with at least one fastener. A transducer may be electrically coupled to the bus bar and have transducer elements. A dielectric material may be disposed between the bus bar and the transducer to prevent debris from contacting the active transducer elements and electrical arcing from occurring.